Role of Hormone Therapy After Primary Surgery for Endometrioma: A Multicenter Retrospective Cohort Study
Endometriosis is a major cause of disability in women, and 40% to 50% of patients experience disease recurrence by 5 years after surgery. This multicenter retrospective cohort study (N = 588) determined the rate and risk factors for recurrent endometrioma after primary surgery and examined the role of postoperative hormone therapy. When recurrence was defined by sonographic identification of the endometrioma (≥20 mm in size), 61 (10.4%) patients experienced disease recurrence. The cumulative recurrence rates at 1, 2, 3, and 5 years after surgery were 2.2%, 4.9%, 6.9%, and 9.8%, respectively. To determine the risk factor...
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Seong, S. J., Kim, D., Lee, K.-H., Kim, T.-J., Chung, H. H., Chang, S.-J., Lee, E.-J. Tags: Original Articles Source Type: research
MicroRNA Expression is Altered in Granulosa Cells of Ovarian Hyperresponders
In conclusion, our findings provide evidence for altered miRNA expression in granulosa cells of women with ovarian hyperresponse, suggesting a role of miRNAs in regulating ovarian response to gonadotropins. (Source: Reproductive Sciences)
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Xie, S., Batnasan, E., Zhang, Q., Li, Y. Tags: Original Articles Source Type: research
The Nrf2 Activator Vinylsulfone Reduces High Glucose-Induced Neural Tube Defects by Suppressing Cellular Stress and Apoptosis
The nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway is one of the primary pathways responsible for the cellular defense system against oxidative stress. Oxidative stress-induced apoptosis is a causal event in diabetic embryopathy. Thus, the Nrf2 pathway may play an important role in the induction of diabetic embryopathy. In the present study, we investigated the potentially protective effect of the Nrf2 activator, vinylsulfone, on high glucose-induced cellular stress, apoptosis, and neural tube defects (NTDs). Embryonic day 8.5 (E8.5) whole mouse embryos were cultured in normal (5 mmol/L) or high (16.7...
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Dong, D., Reece, E. A., Yang, P. Tags: Original Articles Source Type: research
Static Mechanical Loading Influences the Expression of Extracellular Matrix and Cell Adhesion Proteins in Vaginal Cells Derived From Premenopausal Women With Severe Pelvic Organ Prolapse
Conclusions:
Primary human vaginal cells derived from women with severe pelvic organ prolapse and control-HVCs react differentially to in vitro mechanical stretch. Risk factors that induce stretch may alter ECM composition and cell–ECM interaction in pelvic floor tissue leading to the abatement of pelvic organ support and subsequent POP development. (Source: Reproductive Sciences)
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Kufaishi, H., Alarab, M., Drutz, H., Lye, S., Shynlova, O. Tags: Original Articles Source Type: research
Potential Utility of Melatonin in Preeclampsia, Intrauterine Fetal Growth Retardation, and Perinatal Asphyxia
Conclusion:
We believe that the use of melatonin treatment during the late fetal and early neonatal period might result in a wide range of health benefits, improved quality of life, and may help limit complications during the critical periods prior to, and shortly after, delivery. (Source: Reproductive Sciences)
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Marseglia, L., DAngelo, G., Manti, S., Reiter, R. J., Gitto, E. Tags: Review Source Type: research
In the Spotlight
(Source: Reproductive Sciences)
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Maduro, M. R. Tags: In the Spotlight Source Type: research
Histone Deacetylase 1 Regulates the Expression of Progesterone Receptor A During Human Parturition by Occupying the Progesterone Receptor A Promoter
The functional withdrawal of progesterone is mediated by the enhanced expression ratio of the 2 progesterone receptor (PR) isoforms, PRA and PRB, and causes the pregnant human myometrium to switch from a quiet state to a state of excitation–contraction and subsequent laboring. However, the precise mechanisms responsible for alterations in PRA and PRB expression during human parturition have yet to be resolved. In the present study, we report that PRA expression was increased in myometrium samples during labor (P < .001), concomitant with reduced expression of histone deacetylase 1 (HDAC1; P < .01). These result...
Source: Reproductive Sciences - June 14, 2016 Category: Reproduction Medicine Authors: Ke, W., Chen, C., Luo, H., Tang, J., Zhang, Y., Gao, W., Yang, X., Tian, Z., Chang, Q., Liang, Z. Tags: Original Articles Source Type: research
Overexpression of HOXC8 is Associated With Poor Prognosis in Epithelial Ovarian Cancer
In this study, we investigated the expression and role of HOXC8 in ovarian cancer. Western blot and immunohistochemistry analyses were performed to detect the expression of HOXC8. Kaplan-Meier curve showed that high expression of HOXC8 was related to poor prognosis of patients with epithelial ovarian cancer (EOC). Starvation and refeeding assay were used to assess cell cycle, suggesting that HOXC8 played a critical role in EOC cell proliferation. HOXC8 depletion by small interfering RNA inhibited cell proliferation, migration, and induced apoptosis in EOC cells. Moreover, HOXC8 knockdown increased the expression of ZAC1. O...
Source: Reproductive Sciences - June 14, 2016 Category: Reproduction Medicine Authors: Lu, S., Liu, R., Su, M., Wei, Y., Yang, S., He, S., Wang, X., Qiang, F., Chen, C., Zhao, S., Qian, L., Shao, M., Mao, G. Tags: Original Articles Source Type: research
Comparative Characterization of Vaginal Cells Derived From Premenopausal Women With and Without Severe Pelvic Organ Prolapse
Conclusions:
Resting primary POP-HVCs in vitro show altered cellular characteristics as compared to control-HVCs, which may influence their dynamic responses to external mechanical or hormonal stimuli. (Source: Reproductive Sciences)
Source: Reproductive Sciences - June 14, 2016 Category: Reproduction Medicine Authors: Kufaishi, H., Alarab, M., Drutz, H., Lye, S., Shynlova, O. Tags: Original Articles Source Type: research
Adenosine Triphosphate Regresses Endometrial Explants in a Rat Model of Endometriosis
The aim of this study was to determine the effects of adenosine triphosphate (ATP) in a rat endometriosis model. After surgical induction of endometriosis, 3 rats were killed, and explants were measured in the remaining 19 rats, which were then randomly assigned to 4 groups. Group 1 (n = 4) received normal saline (2 mL/d intragastric [IG]), group 2 (n = 4) gestrinone (0.5 mg/kg/d IG), group 3 (n = 5) ATP (3.4 mg/kg/d IG), and group 4 (n = 6) ATP (1.0 mg/kg/d; intramuscularly), respectively. Four weeks after medication, they were euthanized to evaluate histological features of explants and eutopic uterine tissues. To test t...
Source: Reproductive Sciences - June 14, 2016 Category: Reproduction Medicine Authors: Zhang, C., Gao, L., Yi, Y., Han, H., Cheng, H., Ye, X., Ma, R., Sun, K., Cui, H., Chang, X. Tags: Original Articles Source Type: research
Coculture of Preimplantation Embryos With Outgrowth Embryos Improves Embryonic Developmental Competence in Mice
In this study, we established a novel coculture method with outgrowth embryos and investigated how this coculture system improves the preimplantation and peri-implantation embryonic development both in vitro and in utero. We found that outgrowth embryos secrete vesicles, as observed by time-lapse monitoring and scanning electron microscopy. Coculture with outgrowth embryos also significantly increased the percentages of morula, blastocyst, hatching, and outgrowth (P < .01). The total number of cells and inner cell mass were increased, and apoptotic index was decreased (P < .05) by upregulating Survivin and Lif messen...
Source: Reproductive Sciences - June 14, 2016 Category: Reproduction Medicine Authors: Kim, J., Lee, J., Kim, S. H., Jun, J. H. Tags: Original Articles Source Type: research
Efficacy of Tranexamic Acid on Myomectomy-Associated Blood Loss in Patients With Multiple Myomas: A Randomized Controlled Clinical Trial
Conclusion:
The TA reduces blood loss during and after myomectomy for patients with multiple uterine fibroids. (Source: Reproductive Sciences)
Source: Reproductive Sciences - June 14, 2016 Category: Reproduction Medicine Authors: Shaaban, M. M., Ahmed, M. R., Farhan, R. E., Dardeer, H. H. Tags: Original Articles Source Type: research
Human Milk Bacterial and Glycosylation Patterns Differ by Delivery Mode
Mammals have evolved to nourish their offspring exclusively with maternal milk for around half of the lactation period, a crucial developmental window. In view of oral–breast contact during lactation and the differences in oral microbiota between cesarean section (C-section) and vaginally delivered infants, we expected differences in milk composition by delivery mode. We performed a cross-sectional study of banked human milk and found changes related to time since delivery in bacterial abundance and glycosylation patterns only in milk from women who delivered vaginally. The results warrant further research into the e...
Source: Reproductive Sciences - June 14, 2016 Category: Reproduction Medicine Authors: Hoashi, M., Meche, L., Mahal, L. K., Bakacs, E., Nardella, D., Naftolin, F., Bar-Yam, N., Dominguez-Bello, M. G. Tags: Original Articles Source Type: research
Nerve Bundles and Deep Dyspareunia in Endometriosis
This study provides evidence that neurogenesis in the cul-de-sac/uterosacrals may be an etiological factor for deep dyspareunia in endometriosis. (Source: Reproductive Sciences)
Source: Reproductive Sciences - June 14, 2016 Category: Reproduction Medicine Authors: Williams, C., Hoang, L., Yosef, A., Alotaibi, F., Allaire, C., Brotto, L., Fraser, I. S., Bedaiwy, M. A., Ng, T. L., Lee, A. F., Yong, P. J. Tags: Original Articles Source Type: research
Follicle-Stimulating Hormone Receptor Expression in Endometriotic Lesions and the Associated Vasculature: An Immunohistochemical Study
In conclusion, our data suggest novel FSHR expression in endometriotic lesions, qualitatively and quantitatively different from that of normal endometrium. (Source: Reproductive Sciences)
Source: Reproductive Sciences - June 14, 2016 Category: Reproduction Medicine Authors: Robin, B., Planeix, F., Sastre-Garau, X., Pichon, C., Olesen, T. K., Gogusev, J., Ghinea, N. Tags: Original Articles Source Type: research
