Static Mechanical Loading Influences the Expression of Extracellular Matrix and Cell Adhesion Proteins in Vaginal Cells Derived From Premenopausal Women With Severe Pelvic Organ Prolapse

Conclusions:
Primary human vaginal cells derived from women with severe pelvic organ prolapse and control-HVCs react differentially to in vitro mechanical stretch. Risk factors that induce stretch may alter ECM composition and cell–ECM interaction in pelvic floor tissue leading to the abatement of pelvic organ support and subsequent POP development.

Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Kufaishi, H., Alarab, M., Drutz, H., Lye, S., Shynlova, O. Tags: Original Articles Source Type: research