Serum Levels of TNF-{alpha} and IL-6 Are Associated With Pregnancy-Induced Hypertension
In conclusion, our results suggested that high serum TNF-α and IL-6 levels are associated with PIH, and TNF-α and IL-6 might be potential predictors in the prognosis of PIH. (Source: Reproductive Sciences)
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Li, Y., Wang, Y., Ding, X., Duan, B., Li, L., Wang, X. Tags: Original Articles Source Type: research
A Prospective Randomized Controlled Study of Laser-Assisted Hatching on the Outcome of First Fresh IVF-ET Cycle in Advanced Age Women
There is no sufficient data to conclude the benefit of assisted hatching (AH) for advanced age patients. However, AH is routinely performed for advanced age patients undergoing in vitro fertilization (IVF) in China based on some retrospective evidence. It is important to assess the benefit of AH procedure for advanced age patients, especially by analyzing the data from China. This is a prospective randomized controlled trial to evaluate the effect of laser AH in the advanced age patients undergoing IVF. A total of 256 patients conformed to the inclusion criteria, and 78 were excluded by exclusion criteria. A total of 178 p...
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Shi, W., Hongwei, T., Zhang, W., Li, N., Li, M., Li, W., Shi, J. Tags: Original Articles Source Type: research
A Novel Testis-Specific Gene, Ccdc136, Is Required for Acrosome Formation and Fertilization in Mice
In this study, we have identified a novel testis-specific gene, Ccdc136 (coiled-coil domain containing 136), from the results of high-throughput gene expression profiling in the developmental stage of mouse testes. Ccdc136 was conserved across species in evolution. Quantitative real-time polymerase chain reaction and Western blot analyses showed that Ccdc136 messenger RNA and protein were extraordinarily expressed in mouse testes, which was first presented at postnatal 3 week and increased in an age-dependent manner before adulthood. Immunofluorescence staining revealed that CCDC136 protein was most abundantly located in t...
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Geng, Q., Ni, L., Ouyang, B., Hu, Y., Zhao, Y., Guo, J. Tags: Original Articles Source Type: research
Are There Differences in Placental Volume and Uterine Artery Doppler in Pregnancies Resulting From the Transfer of Fresh Versus Frozen-Thawed Embryos Through In Vitro Fertilization
Conclusion:
First-trimester placental volume, as assessed by 3D ultrasound, is reduced in IVF pregnancies, and these differences are more marked in those obtained with fresh embryos than those obtained with cryopreservation. This may explain the better obstetrical and perinatal outcomes occurring with the former technique. (Source: Reproductive Sciences)
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Rizzo, G., Aiello, E., Pietrolucci, M. E., Arduini, D. Tags: Original Articles Source Type: research
Analysis of Clusterin and Clusterin Receptors in the Endometrium and Clusterin Levels in Cervical Mucus of Endometriosis
Clusterin (CLU) is expressed in tissues and body fluids and is altered in some pathologies. In endometriosis, a noninvasive test is still lacking, thus, we analyzed CLU in mucus samples of patients. Additionally, we investigated localization of CLU and the putative CLU receptors (apolipoprotein E receptor 2 [ApoER2], megalin, very low-density lipoprotein receptor [VLDLR], and transforming growth factor β receptor type I and II [TβR1/TβR2]). In mucus samples, CLU levels are modestly, but not significantly, higher in cases with endometriosis compared to cases without endometriosis, however, CLU levels are sign...
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Konrad, L., Hackethal, A., Oehmke, F., Berkes, E., Engel, J., Tinneberg, H.-R. Tags: Original Articles Source Type: research
Analysis of Serum microRNA Profile by Solexa Sequencing in Women With Endometriosis
Conclusion:
Circulating miRNAs may be useful as detection biomarkers for the early diagnosis of minimal–mild endometriosis. (Source: Reproductive Sciences)
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Wang, L., Huang, W., Ren, C., Zhao, M., Jiang, X., Fang, X., Xia, X. Tags: Original Articles Source Type: research
Inhibition of Wnt Inhibitory Factor 1 Under Hypoxic Condition in Human Umbilical Vein Endothelial Cells Promoted Angiogenesis in Vitro
In conclusion, our present study supported the hypothesis that WIF1 is crucial as a negative regulator of the functions of endothelial cells in angiogenesis and that hypoxia plays an important role in controlling WIF1 expression and angiogenesis. We also demonstrated that Wnt/β-catenin signaling pathway was activated in correspondence with the suppression of WIF1 in the angiogenesis of endothelial cells under hypoxic conditions. (Source: Reproductive Sciences)
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Chen, Y., Zhang, Y., Deng, Q., Shan, N., Peng, W., Luo, X., Zhang, H., Baker, P. N., Tong, C., Qi, H. Tags: Original Articles Source Type: research
Integrated Data Set of microRNAs and mRNAs Involved in Severe Intrauterine Adhesion
Conclusion:
This study provides an integrated data set of the miRNA and mRNA profiles in severe IUA, showing involvement of many miRNAs and their target genes. Further analysis of these genes will help in understanding of the molecular mechanism of IUA formation. (Source: Reproductive Sciences)
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Liu, X., Duan, H., Zhang, H.-H., Gan, L., Xu, Q. Tags: Original Articles Source Type: research
Laparoscopic Surgery: A New Technique to Induce Endometriosis in a Mouse Model
Conclusions:
To the best our knowledge, this is the first report showing that endometriosis can be induced by laparoscopic surgery in rodents, with a 100% incidence and a median peritoneal implant take rate of 60%. This laparoscopic model offers important advantages over traditional laparotomy models that are limited by surgery-associated trauma and/or adhesion formation. (Source: Reproductive Sciences)
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Peterse, D. P., Fassbender, A., O, D. F., Vanhie, A., Saunders, P., Vriens, J., Binda, M. M., DHooghe, T. M. Tags: Original Articles Source Type: research
Endometrial Injury May Increase the Pregnancy Rate in Patients Undergoing Intrauterine Insemination: An Interventional Randomized Clinical Trial
Conclusion:
Endometrial injury using a Pipelle catheter in the stimulation cycle may improve pregnancy rates in women undergoing intrauterine insemination. (Source: Reproductive Sciences)
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Bahaa Eldin, A. M., Abdelmaabud, K. H., Laban, M., Hassanin, A. S., Tharwat, A. A., Aly, T. R., Elbohoty, A. E., Elsayed, H. M., Ibrahim, A. M., Ibrahim, M. E., Sabaa, H. M., Abdelrazik, A. A., Abdelhady, I. Tags: Original Articles Source Type: research
Identification of Polycomb Group Protein EZH2-Mediated DNA Mismatch Repair Gene MSH2 in Human Uterine Fibroids
In this study, we used human fibroid and adjacent myometrial tissues, as well as an in vitro cell culture model, to evaluate the expression of MutS homolog 2 (MSH2), which encodes a protein belongs to the mismatch repair system. In addition, we deciphered the mechanism by which polycomb repressive complex 2 protein, EZH2, deregulates MSH2 in UFs. The RNA expression analysis demonstrated the deregulation of MSH2 expression in UF tissues in comparison to its adjacent myometrium. Notably, protein levels of MSH2 were upregulated in 90% of fibroid tissues (9 of 10) as compared to matched adjacent myometrial tissues. Human fibro...
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Yang, Q., Laknaur, A., Elam, L., Ismail, N., Gavrilova-Jordan, L., Lue, J., Diamond, M. P., Al-Hendy, A. Tags: Original Articles Source Type: research
Age at Menarche and Gallstone Disease in Middle-Aged Women
The goal of this study was to explore the association between age at menarche and gallstone disease (GSD) in Korean women and to determine whether any of the observed associations were mediated by adult adiposity. A cross-sectional study was performed on 83 275 Korean women, aged 30 years or older, who underwent a health checkup examination between March 2011 and April 2013. Information regarding age at menarche was collected using standardized, self-administered questionnaires. Gallstone disease was defined as either having gallstones or having had a cholecystectomy based on ultrasound. Logistic regression models were use...
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Ryu, S., Chang, Y., Choi, Y., Kwon, M.-J., Yun, K. E., Jung, H.-S., Kim, B.-K., Kim, Y. J., Kim, K.-H., Cho, J., Chung, E. C., Shin, H., Suh, B. S. Tags: Original Articles Source Type: research
Global Transcriptome Abnormalities of the Eutopic Endometrium From Women With Adenomyosis
Conclusion:
The eutopic endometrium in patients with adenomyosis has fundamental abnormalities that may predispose to invasion and survival beyond the myometrial interface. (Source: Reproductive Sciences)
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Herndon, C. N., Aghajanova, L., Balayan, S., Erikson, D., Barragan, F., Goldfien, G., Vo, K. C., Hawkins, S., Giudice, L. C. Tags: Original Articles Source Type: research
Origins and Progression of Adolescent Endometriosis
Accumulating evidence indicates that adolescent endometriosis is common and often severe. Here we explore the possibility that seeding of naive endometrial progenitor cells into the pelvic cavity early in life, that is, at the time of neonatal uterine bleeding or soon after the menarche, results in more florid and progressive disease, characterized by highly angiogenic implants, recurrent ectopic bleeding, and endometrioma formation. We discuss the potential intergenerational risk factors associated with early-onset endometriosis and explore the molecular drivers of disease progression. Taken together, the available data s...
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Brosens, I., Gargett, C. E., Guo, S.-W., Puttemans, P., Gordts, S., Brosens, J. J., Benagiano, G. Tags: Review Source Type: research
In the Spotlight
(Source: Reproductive Sciences)
Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Maduro, M. R. Tags: In the Spotlight Source Type: research
