Inhibition of Wnt Inhibitory Factor 1 Under Hypoxic Condition in Human Umbilical Vein Endothelial Cells Promoted Angiogenesis in Vitro

In conclusion, our present study supported the hypothesis that WIF1 is crucial as a negative regulator of the functions of endothelial cells in angiogenesis and that hypoxia plays an important role in controlling WIF1 expression and angiogenesis. We also demonstrated that Wnt/β-catenin signaling pathway was activated in correspondence with the suppression of WIF1 in the angiogenesis of endothelial cells under hypoxic conditions.

Source: Reproductive Sciences - September 13, 2016 Category: Reproduction Medicine Authors: Chen, Y., Zhang, Y., Deng, Q., Shan, N., Peng, W., Luo, X., Zhang, H., Baker, P. N., Tong, C., Qi, H. Tags: Original Articles Source Type: research