Bisphenol A Concentrates Preferentially in Human Uterine Leiomyoma and Induces Proliferation in Rat Myometrium
Conclusion:
Bisphenol A concentrates in human ULM tissue and its adjacent Myo-F compared to Myo-N. No significant difference is detected in BPA content of ULM tissue of different subtypes. Bisphenol A increases thickness and induces cellular proliferation in rat myometrium. Taken together, our results support a role of BPA in ULM development/growth. (Source: Reproductive Sciences)
Source: Reproductive Sciences - March 18, 2016 Category: Reproduction Medicine Authors: Othman, E. R., Al-Adly, D. M. M., Elgamal, D. A., Ghandour, N., El-Sharkawy, S. Tags: Original Articles Source Type: research
The Defensive Role of Cumulus Cells Against Reactive Oxygen Species Insult in Metaphase II Mouse Oocytes
We investigated the ability of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), hydroxyl radical (·OH), and hypochlorous acid (HOCl), to overcome the defensive capacity of cumulus cells and elucidate the mechanism through which ROS differentially deteriorate oocyte quality. Metaphase II mouse oocytes with (n = 1634) and without cumulus cells (n = 1633) were treated with increasing concentration of ROS, and the deterioration in oocyte quality was assessed by the changes in the microtubule morphology and chromosomal alignment. Oocyte and cumulus cell viability and cumulus cell number were assessed by i...
Source: Reproductive Sciences - March 18, 2016 Category: Reproduction Medicine Authors: Shaeib, F., Khan, S. N., Ali, I., Thakur, M., Saed, M. G., Dai, J., Awonuga, A. O., Banerjee, J., Abu-Soud, H. M. Tags: Original Articles Source Type: research
Different Expression of Hypoxic and Angiogenic Factors in Human Endometriotic Lesions
Endometriosis is associated with local angiogenic and hypoxic mechanisms. Indeed, peritoneal fluid of women with endometriosis generates a specific microenvironment to support the growth and development of ectopic endometrial tissues. The association between proangiogenic markers and hypoxic processes in different endometriosis phenotypes was investigated in the present study, analyzing the expression of several genes, related to hypoxic signaling pathway and involved in angiogenic processes, in nonpregnant women with different forms of endometriosis. Samples of ovarian endometrioma (OMA; n = 16) or deep infiltrating endom...
Source: Reproductive Sciences - March 18, 2016 Category: Reproduction Medicine Authors: Filippi, I., Carrarelli, P., Luisi, S., Batteux, F., Chapron, C., Naldini, A., Petraglia, F. Tags: Original Articles Source Type: research
A Cross-Species Analysis of Animal Models for the Investigation of Preterm Birth Mechanisms
Conclusion:
The process of developing a search algorithm to provide efficient access to information on animal models of preterm birth illustrates the need for a more precise organization of the literature to allow the investigator to focus on distinctly maternal versus fetal outcomes. (Source: Reproductive Sciences)
Source: Reproductive Sciences - March 18, 2016 Category: Reproduction Medicine Authors: Nielsen, B. W., Bonney, E. A., Pearce, B. D., Donahue, L. R., Sarkar, I. N., for the Preterm Birth International Collaborative (PREBIC) Tags: Original Articles Source Type: research
Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy
Our aim was to determine whether placental A Disintegrin-like Metalloproteinase with ThromboSpondin motif 12 (ADAMTS-12), arylesterase (ARES) levels, total oxidant status (TOS), and total antioxidant status (TAS) differ in preeclampsia, intrahepatic cholestasis of pregnancy (ICP), and uncomplicated pregnancies or not. A prospective case–control study was carried out including 84 pregnant women (26 with ICP, 28 preeclamptic patients, and 30 healthy controls). Levels of ADAMTS-12, TAS, TOS, and ARES were studied in the supernatants of placental tissue homogenates. Placental ADAMTS-12 levels were distributed as 240.9 pg...
Source: Reproductive Sciences - March 18, 2016 Category: Reproduction Medicine Authors: Oztas, E., Ozler, S., Ersoy, A. O., Erkenekli, K., Sucak, A., Ergin, M., Uygur, D., Danisman, N. Tags: Original Articles Source Type: research
Targeted Adenoviral Vector Demonstrates Enhanced Efficacy for In Vivo Gene Therapy of Uterine Leiomyoma
Conclusion:
Targeted adenovirus, effectively reduces tumor size in leiomyoma without dissemination to other organs. Further evaluation of this localized targeted strategy for gene therapy is needed in appropriate preclinical humanoid animal models in preparation for a future pilot human trial. (Source: Reproductive Sciences)
Source: Reproductive Sciences - March 18, 2016 Category: Reproduction Medicine Authors: Abdelaziz, M., Sherif, L., ElKhiary, M., Nair, S., Shalaby, S., Mohamed, S., Eziba, N., El-Lakany, M., Curiel, D., Ismail, N., Diamond, M. P., Al-Hendy, A. Tags: Original Articles Source Type: research
Aberrant HOXA10 Methylation in Patients With Common Gynecologic Disorders: Implications for Reproductive Outcomes
This study describes the differences in methylation patterns of HOXA10 gene in uterine myomas, endometriosis, uterine septum, Asherman syndrome, or uterine polyps of women undergoing hysteroscopic surgery. In the endometrium of uteri with polyps, submucosal myomas, and intramural myomas, there were CpG sites within the HOXA10 gene that were highly methylated compared to controls. The HOXA10 gene in women with endometriosis was hypomethylated compared to controls. DNA methylation may be a common molecular mechanism that results in reproductive dysfunction seen in gynecologic disease. (Source: Reproductive Sciences)
Source: Reproductive Sciences - March 18, 2016 Category: Reproduction Medicine Authors: Kulp, J. L., Mamillapalli, R., Taylor, H. S. Tags: Original Articles Source Type: research
Depo-Provera Versus Norethisterone Acetate in Management of Endometrial Hyperplasia Without Atypia
The objective of this study was to assess effectiveness and safety of Depo-Provera (medroxyprogesterone acetate) in treatment of endometrial hyperplasia (EH) and to compare it with norethisterone acetate (NETA) as an oral progestogen treatment. One hundred forty six women aged 35 to 50 years with abnormal uterine bleeding and diagnosed as having EH were randomized to receive either Depo-Provera, one injection every 3 months for 6 months (2 doses), or oral cyclic NETA, 15 mg daily for 14 days per cycle for 6 months. Primary outcome measure was regression of EH. Secondary outcome variables were side effects of treatment, per...
Source: Reproductive Sciences - March 18, 2016 Category: Reproduction Medicine Authors: Nooh, A. M., Abdeldayem, H. M., Girbash, E. F., Arafa, E. M., Atwa, K., Abdel-Raouf, S. M. Tags: Original Articles Source Type: research
Effects of the Oral Oxytocin Receptor Antagonist Tocolytic OBE001 on Reproduction in Rats
Conclusion:
OBE001 at up to 125 mg/kg/d had no effects on EED and no adverse effects on FD and postnatal development of rats. These results constitute an important step toward the development of OBE001 in preterm labor and ART indications. (Source: Reproductive Sciences)
Source: Reproductive Sciences - March 18, 2016 Category: Reproduction Medicine Authors: Pohl, O., Perks, D., Rhodes, J., Comotto, L., Baldrick, P., Chollet, A. Tags: Original Articles Source Type: research
In Vitro Activation: A Possible New Frontier for Treatment of Primary Ovarian Insufficiency
In vitro activation (IVA) represents a new frontier in the treatment of women with primary ovarian insufficiency as well as patients with cancer desiring fertility preservation. Here, we review the biological basis of IVA and the recent translation of IVA to humans by targeting Hippo and Akt-signaling pathways. We then provide a new integrated viewpoint on IVA, highlighting basic science research on the aspects of follicular development and ovarian tissue transplantation which may potentially optimize future translational research on IVA. Specific topics discussed include cryopreservation techniques, additional IVA pathway...
Source: Reproductive Sciences - March 18, 2016 Category: Reproduction Medicine Authors: Cordeiro, C. N., Christianson, M. S., Selter, J. H., Segars, J. H. Tags: Reviews Source Type: research
Statins as Targeted "Magical Pills" for the Conservative Treatment of Endometriosis: May Potential Adverse Effects on Female Fertility Represent the "Dark Side of the Same Coin"? A Systematic Review of Literature
The aim of the study was to analyze all the available evidence from both in vitro and in vivo studies regarding the efficacy of statin therapy in the treatment of endometriosis, evaluating the potential efficacy, side effects, and contraindications of their administration in humans. We focused on defining the potential benefits that the administration of statins may have on patients affected by endometriosis and the possible adverse effects of such a therapy on ovarian function and fertility profile. According to our article selection criteria, we included in the review in vitro and in vivo studies performed on human or an...
Source: Reproductive Sciences - March 18, 2016 Category: Reproduction Medicine Authors: Vitagliano, A., Noventa, M., Quaranta, M., Gizzo, S. Tags: Reviews Source Type: research
In the Spotlight
(Source: Reproductive Sciences)
Source: Reproductive Sciences - March 18, 2016 Category: Reproduction Medicine Authors: Maduro, M. R. Tags: In the Spotlight Source Type: research
Scientific Abstracts
(Source: Reproductive Sciences)
Source: Reproductive Sciences - March 17, 2016 Category: Reproduction Medicine Tags: Articles Source Type: research
President's Plenary Session
(Source: Reproductive Sciences)
Source: Reproductive Sciences - March 17, 2016 Category: Reproduction Medicine Tags: Articles Source Type: research
Single-Nucleotide Polymorphisms and Haplotypes of Intercellular Adhesion Molecule-1 in Uterine Cervical Carcinogenesis in Taiwanese Women
In conclusion, Taiwanese women with ICAM-1 SNP rs281432 and haplotypes CG/TA/TG of rs3093030 and rs5498 are associated with uterine cervical carcinogenesis. (Source: Reproductive Sciences)
Source: Reproductive Sciences - February 8, 2016 Category: Reproduction Medicine Authors: Sun, Y.-H., Yang, S.-F., Liu, Y.-F., Ko, J.-L., Wu, C.-H., Wu, T.-F., Wang, P.-H. Tags: Original Articles Source Type: research
