Endometrial Receptivity Markers in Mice Stimulated With Raloxifene Versus Clomiphene Citrate and Natural Cycles
This study aimed to compare the expression of endometrial receptivity markers, including homeobox gene 10 (HOXA10), integrin β3, and leukemia inhibitory factor (LIF), as well as pinopode production during the implantation window in mice stimulated with raloxifene and clomiphene citrate and natural cycles. Thirty-six 8-week-old female Kunming mice were randomly divided into 3 groups (n = 12) and administered daily raloxifene (22 mg/kg), clomiphene citrate (18 mg/kg), and normal saline (1 mL), respectively, by gavage. Two days later, mice were injected with 5 IU human chorionic gonadotropin and mated. Successfully mated...
Source: Reproductive Sciences - May 10, 2016 Category: Reproduction Medicine Authors: Chen, C., Yan, Q., Liu, K., Zhou, X., Xian, Y., Liang, D., Zhao, X., Guo, X., Quan, S. Tags: Original Articles Source Type: research
Altered Maternal Plasma Glycogen Phosphorylase Isoenzyme BB as a Biomarker for Preeclampsia and Small for Gestational Age
Conclusion:
Glycogen phosphorylase BB alone has modest predictive abilities for the development of preeclampsia or SGA. Further research may examine its use in combination with other markers. (Source: Reproductive Sciences)
Source: Reproductive Sciences - May 10, 2016 Category: Reproduction Medicine Authors: McCarthy, F. P., Doyle, A., Khashan, A. S., Kenny, L. C. Tags: Original Articles Source Type: research
Candidate Gene and MicroRNA Expression in Fetal Membranes and Preterm Delivery Risk
We investigated candidate gene and microRNA (miRNA) expression in amnion and chorion in relation to risk of preterm delivery (PTD). Amnion and chorion were separated from placenta and collected at delivery from participants who delivered at term (N = 10) and from participants who delivered preterm following spontaneous labor (sPTL-PTD; N = 10), premature rupture of membranes (PPROM-PTD; N = 10), and preeclampsia (PE-PTD; N = 10). Expression of genes (metalloproteinase [MMP] 2, MMP-9, and tissue inhibitors of MMP-1) and miRNAs (miR-199a*, -202*, -210, -214, -223, and -338) was profiled using quantitative real-time polymeras...
Source: Reproductive Sciences - May 10, 2016 Category: Reproduction Medicine Authors: Enquobahrie, D. A., Hensley, M., Qiu, C., Abetew, D. F., Hevner, K., Tadesse, M. G., Williams, M. A. Tags: Original Articles Source Type: research
Mifepristone is a Vasodilator Due to the Inhibition of Smooth Muscle Cells L-Type Ca2+ Channels
Derived from the estrane progestins, mifepristone was the first synthetic steroid of this class employed as abortifacient in the first months of pregnancy. Mifepristone reduces high potassium-induced contraction and prevents calcium-induced contraction. At the vascular level, mifepristone induces direct relaxation in rat and human arteries, and this effect seems to be endothelium- and NO independent, suggesting that the vascular smooth muscle is its target. Moreover, mifepristone’s effect could involve the modulation of different calcium channels. The aim of the present study is to analyze the involvement of calcium ...
Source: Reproductive Sciences - May 10, 2016 Category: Reproduction Medicine Authors: Mariana, M., Feiteiro, J., Cairrao, E., Verde, I. Tags: Original Articles Source Type: research
Trophoblast Retrieval and Isolation From the Cervix for Noninvasive, First Trimester, Fetal Gender Determination in a Carrier of Congenital Adrenal Hyperplasia
Congenital adrenal hyperplasia (CAH) is an autosomal recessive defect in cortisol biosynthesis that elevates fetal androgen levels to cause genital ambiguity and external genital masculinization in newborn females. Introducing dexamethasone in utero by 7 weeks gestation precludes virilization of affected females. However, identification of a male fetus prior to week 7 could avert the necessity of steroid treatment in half of pregnancies at risk of CAH. We recently introduced trophoblast retrieval and isolation from the cervix (TRIC), an approach that noninvasively isolate homogeneous trophoblast cells from pregnant women a...
Source: Reproductive Sciences - May 10, 2016 Category: Reproduction Medicine Authors: Bolnick, A. D., Fritz, R., Jain, C., Kadam, L., Bolnick, J. M., Kilburn, B. A., Singh, M., Diamond, M. P., Drewlo, S., Armant, D. R. Tags: Original Articles Source Type: research
Follicle-Stimulating Hormone: A Review of Form and Function in the Treatment of Infertility
The use of gonadotropin therapy, including follicle-stimulating hormone (FSH), represents an indispensable part of fertility treatment. There are a number of FSH preparations commercially available or in development, including both urinary-derived products (urinary-derived FSH [uFSH]) and FSH produced through recombinant techniques (recombinant FSH [rFSH]). Differences in the glycosylation patterns of FSH give rise to a number of naturally occurring isoforms that may differ functionally. The relative concentrations of these isoforms vary over the course of the menstrual cycle and the lifetime, indicating that these differe...
Source: Reproductive Sciences - May 10, 2016 Category: Reproduction Medicine Authors: Smitz, J., Wolfenson, C., Chappel, S., Ruman, J. Tags: Review Source Type: research
Larry Longo: A Life Worthwhile
(Source: Reproductive Sciences)
Source: Reproductive Sciences - May 10, 2016 Category: Reproduction Medicine Authors: Reece, E. A. Tags: Editorial Source Type: research
In the Spotlight
(Source: Reproductive Sciences)
Source: Reproductive Sciences - May 10, 2016 Category: Reproduction Medicine Authors: Maduro, M. R. Tags: In the Spotlight Source Type: research
e-Corrigendum
(Source: Reproductive Sciences)
Source: Reproductive Sciences - May 10, 2016 Category: Reproduction Medicine Tags: Articles Source Type: research
The Impact of Multiparity on Uterine Gene Expression and Decidualization in Mice
It has been well established that a previous pregnancy exhibits a beneficial effect on the subsequent pregnancy. However, the underlying mechanisms have not been defined. We hypothesized that multiparity may affect decidualization process during early pregnancy. To test this hypothesis, we analyzed global gene changes associated with multiparity in the mouse uterus using RNA-sequencing (RNA-seq). We identified a total of 131 differentially expressed genes (fold change > 2 and false discovery rate < 0.05), of which 58 were downregulated and 73 genes were upregulated in the second pregnancy (SP) compared to the first p...
Source: Reproductive Sciences - April 12, 2016 Category: Reproduction Medicine Authors: Liu, J.-L., Zuo, R.-J., Peng, Y., Fu, Y.-S. Tags: Original Articles Source Type: research
Steroid Pathway Genes and Neonatal Respiratory Distress After Betamethasone Use in Anticipated Preterm Birth
Conclusion:
Single-nucleotide polymorphisms in several glucocorticoid responsive genes suggest association with neonatal RDS after antenatal corticosteroid use. (Source: Reproductive Sciences)
Source: Reproductive Sciences - April 12, 2016 Category: Reproduction Medicine Authors: Haas, D. M., Lai, D., Sharma, S., Then, J., Kho, A., Flockhart, D. A., Tantisira, K., Foroud, T. Tags: Original Articles Source Type: research
Cysteine Prevents Menopausal Syndromes in Ovariectomized Mouse
This study aims to find an unrevealed effect of Cys with estrogenic and osteogenic actions. Ovariectomized (OVX) mice were treated with Cys daily for 8 weeks. Estrogen-related and osteoporosis-related factors were analyzed in the vagina, serum, and tibia. Cys was treated in estrogen receptor (ER)-positive human osteoblast-like MG-63 cells and ER-positive human breast cancer Michigan Cancer Foundation-7 (MCF-7) cells. Cysteine administration ameliorated overweightness of the body and vaginal atrophy in the OVX mice. Cysteine increased the levels of alkaline phosphatase (ALP) and 17β-estradiol in the serum of the OVX mi...
Source: Reproductive Sciences - April 12, 2016 Category: Reproduction Medicine Authors: Han, N.-R., Kim, N.-R., Kim, H.-M., Jeong, H.-J. Tags: Original Articles Source Type: research
A Humanized Anti-Interleukin 6 Receptor Monoclonal Antibody, Tocilizumab, for the Treatment of Endometriosis in a Rat Model
Conclusion:
Tocilizumab treatment had a regressive effect on the endometriotic implants. (Source: Reproductive Sciences)
Source: Reproductive Sciences - April 12, 2016 Category: Reproduction Medicine Authors: Taskin, M. I., Gungor, A. C., Adali, E., Yay, A., Onder, G. O., Inceboz, U. Tags: Original Articles Source Type: research
The Role of Anti-Müllerian Hormone in the Characterization of the Different Polycystic Ovary Syndrome Phenotypes
Rotterdam criteria identified 4 polycystic ovary syndrome (PCOS) phenotypes based on the combination of anovulation (ANOV), hyperandrogenism (HA), and polycystic ovaries (PCOs): phenotype 1 (ANOV + HA + PCO), phenotype 2 (ANOV + HA), phenotype 3 (HA + PCO), and phenotype 4 (ANOV + PCO). Anti-Müllerian hormone (AMH) was suggested to play a pathophysiologic and diagnostic role in this syndrome. The aim of this study was to compare AMH levels among the different phenotypes in relation to clinical, endocrine, and metabolic features. We enrolled 117 women with PCOS (body mass index: 25.89 ± 6.20 kg/m2, age range:...
Source: Reproductive Sciences - April 12, 2016 Category: Reproduction Medicine Authors: Romualdi, D., Di Florio, C., Tagliaferri, V., De Cicco, S., Gagliano, D., Immediata, V., Lanzone, A., Guido, M. Tags: Original Articles Source Type: research
A Nonrandomized Trial of Progressive Resistance Training Intervention in Women With Polycystic Ovary Syndrome and Its Implications in Telomere Content
Conclusions:
Progressive resistance training had positive effects on the hormonal and physical characteristics of women with PCOS and controls, but telomere content was reduced and homocysteine level increased in all participants. (Source: Reproductive Sciences)
Source: Reproductive Sciences - April 12, 2016 Category: Reproduction Medicine Authors: Miranda-Furtado, C. L., Ramos, F. K. P., Kogure, G. S., Santana-Lemos, B. A., Ferriani, R. A., Calado, R. T., dos Reis, R. M. Tags: Original Articles Source Type: research
