Therapeutic Potential of Human Chorionic Gonadotropin Against Overactive Bladder
Overactive bladder (OAB) is a common form of urinary incontinence, resulting from spontaneous and random contractions of the urinary bladder. The affected individuals have an uncontrollable urge to urinate and experience incontinence and nocturia, which can greatly reduce the quality of daily life. There are several drugs for the treatment, and all of them have serious side effects. The following findings suggested that human chorionic gonadotropin (hCG) has a therapeutic potential that is worth investigating for the treatment of OAB. The finding are (1) human detrusor muscle contains hCG receptors, (2) detrusor muscle bec...
Source: Reproductive Sciences - August 8, 2016 Category: Reproduction Medicine Authors: Rao, C. V. Tags: Reviews Source Type: research
In the Spotlight
(Source: Reproductive Sciences)
Source: Reproductive Sciences - August 8, 2016 Category: Reproduction Medicine Authors: Maduro, M. R. Tags: In the Spotlight Source Type: research
Corrigendum
(Source: Reproductive Sciences)
Source: Reproductive Sciences - August 8, 2016 Category: Reproduction Medicine Tags: Articles Source Type: research
Enhancing Adenoviral-Mediated Gene Transfer and Expression to Endometrial Cells
Conclusions:
We conclude that when compared to the wild-type adenovirus, Ad-RGD-luc, Ad-SLPI-luc, and Ad-heparanase-luc mediate higher reporter gene activity in endometrial cells and can work as effective gene transfer vectors in gene therapy applications to the endometrium. (Source: Reproductive Sciences)
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Othman, E. R., Curiel, D. T., Hussein, M., Abdelaal, I. I., Fetih, A. N., Al-Hendy, A. Tags: Original Articles Source Type: research
In Estimated Good Prognosis Patients Could Unexpected "Hyporesponse" to Controlled Ovarian Stimulation be Related to Genetic Polymorphisms of FSH Receptor?
In this study, FSH receptor polymorphism was retrospectively evaluated in 42 normoresponder young women undergoing an in vitro fertilization/intracytoplasmic sperm injection cycle; patients were stratified according to recombinant human FSH (r-hFSH) consumption. We selected 17 normoresponder young patients who required a cumulative dose of recombinant FSH (rFSH) >2500 UI (group A). A control group was randomly selected among patients who required a cumulative dose of rFSH <2500 UI (group B). Follicle-stimulating hormone receptor (FSH-R) 307Ala and 680Ser variants were analyzed in all our patients. Our results show th...
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Alviggi, C., Conforti, A., Caprio, F., Gizzo, S., Noventa, M., Strina, I., Pagano, T., De Rosa, P., Carbone, F., Colacurci, N., De Placido, G. Tags: Original Articles Source Type: research
Aberrant Methylation of the E-Cadherin Gene Promoter Region in the Endometrium of Women With Uterine Fibroids
This study aims to investigate the methylation status of the E-cadherin gene (CDH1) promoter region in the endometrium of patients with uterine fibroids. The methylation of CDH1 was studied using methylation-specific polymerase chain reaction in the endometrial tissue of 102 patients with uterine fibroids and 50 control patients. The E-cadherin expression was examined by flow cytometry. The methylation rate of CDH1 promoter region was 33.3% in the endometrium of patients with uterine fibroids and 8% in the endometrium of women without fibroids. The frequency of CDH1 promoter methylation in the endometrium of patients with ...
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Li, Y., Ran, R., Guan, Y., Zhu, X., Kang, S. Tags: Original Articles Source Type: research
Gene Targeting to the Uteroplacental Circulation of Pregnant Guinea Pigs
This study suggests an optimal method of gene delivery to the UtAs of a small rodent for preclinical studies. (Source: Reproductive Sciences)
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Mehta, V., Ofir, K., Swanson, A., Kloczko, E., Boyd, M., Barker, H., Avdic-Belltheus, A., Martin, J., Zachary, I., Peebles, D., David, A. L. Tags: Original Articles Source Type: research
Expression and Regulation of Pituitary Adenylate Cyclase-Activating Polypeptide in Rat Placental Cells
In this study, we used primary cultures of placental tissues from rats of 16 to 18 days gestation and examined the regulation and function of PACAP. The PACAP messenger RNA (mRNA) expression and PACAP-immunoreactive cells were detected in primary cultures of rat placental cells. The PACAP mRNA expression in placental cells was upregulated in the presence of the sex steroids estradiol and progesterone; however, their combined treatment failed to enhance their individual effects. When the cells were stimulated with kisspeptin, PACAP mRNA expression was increased. Similarly, GnRH had a stimulatory effect on PACAP expression. ...
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Oride, A., Kanasaki, H., Mijiddorj, T., Sukhbaatar, U., Yamada, T., Kyo, S. Tags: Original Articles Source Type: research
Elevated Systemic Levels of Endocannabinoids and Related Mediators Across the Menstrual Cycle in Women With Endometriosis
Cannabinoids and modulators of the endocannabinoid system affect specific mechanisms that are critical to the establishment and development of endometriosis. The aim of this study was to measure the systemic levels of endocannabinoids and related mediators in women with and without endometriosis and to investigate whether such levels correlated with endometriosis-associated pain. Plasma and endometrial biopsies were obtained from women with a laparoscopic diagnosis of endometriosis (n = 27) and no endometrial pathology (n = 29). Plasma levels of endocannabinoids (N-arachidonoylethanolamine [AEA] and 2-arachidonoylglycerol ...
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Sanchez, A. M., Cioffi, R., Vigano, P., Candiani, M., Verde, R., Piscitelli, F., Di Marzo, V., Garavaglia, E., Panina-Bordignon, P. Tags: Original Articles Source Type: research
Effect of Human Umbilical Cord Mesenchymal Stem Cell Transplantation in a Rat Model of Preeclampsia
Conclusion:
In summary, HU-MSC transplantation may be extremely beneficial for PE therapy. (Source: Reproductive Sciences)
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Wang, L.-L., Yu, Y., Guan, H.-B., Qiao, C. Tags: Original Articles Source Type: research
The Presence of Endometrioma Does Not Impair Time-Lapse Morphokinetic Parameters and Quality of Embryos: A Study On Sibling Oocytes
Conclusions:
According to the morphokinetic parameters, this study further strengthens the notion that removal of endometriomas before IVF is not a necessity in terms of better oocyte quality and development. (Source: Reproductive Sciences)
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Demirel, C., Bastu, E., Aydogdu, S., Donmez, E., Benli, H., Tuysuz, G., Keskin, G., Buyru, F. Tags: Original Articles Source Type: research
Endometriosis-Derived Stromal Cells Secrete Thrombin and Thromboxane A2, Inducing Platelet Activation
Platelets have been recently revealed to play important roles in the development of endometriosis. However, it is unclear whether endometriotic lesions can secrete any platelet inducers outside the menstruation window. Hence, this study was undertaken to see whether endometriosis-derived stromal cells secrete platelet activators and cause platelet activation. We employed in vitro experimentation using primary ectopic endometrial stromal cells (EESCs) and platelets from healthy male volunteers and evaluated the extent of platelet aggregation by aggregometer and the platelet activation rate by flow cytometry using supernatan...
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Guo, S.-W., Du, Y., Liu, X. Tags: Original Articles Source Type: research
Apelin in Normal Pregnancy and Pregnancies Complicated by Placental Insufficiency
Conclusions:
Apelin levels mirror the cardiovascular changes seen in pregnancy. Serum and placental apelin levels are decreased in IUGR. (Source: Reproductive Sciences)
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Van Mieghem, T., Doherty, A., Baczyk, D., Drewlo, S., Baud, D., Carvalho, J., Kingdom, J. Tags: Original Articles Source Type: research
Endothelin Receptor A Antagonism and Fetal Growth in Endothelial Nitric Oxide Synthase Gene Knockout Maternal and Fetal Mice
Fetal growth restriction (FGR) is commonly associated with perinatal morbidity and mortality. Nitric oxide (NO) deficiency increases endothelin-1 (ET-1) production, and this increased ET-1 may contribute to the pathophysiology of NO deficiency-induced FGR. Using an endothelial NO synthase knockout mouse model of FGR, we sought to determine (a) the relative importance of maternal versus conceptus (fetal and placental) NO deficiency and (b) the contribution of ET-1 to the pathogenesis of FGR in this model. Fetal growth restriction occurred both with NO-deficient conceptuses in the setting of maternal NO production and with m...
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Luo, K., Thaete, L. G., Neerhof, M. G. Tags: Original Articles Source Type: research
Age-Specific Normal Reference Range for Serum Anti-Müllerian Hormone in Healthy Chinese Han Women: A nationwide Population-Based Study
Conclusions:
This study determined the normal reference ranges for serum AMH levels in a large population-based sample of healthy Chinese women. (Source: Reproductive Sciences)
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Du, X., Ding, T., Zhang, H., Zhang, C., Ma, W., Zhong, Y., Qu, W., Zheng, J., Liu, Y., Li, Z., Huang, K., Deng, S., Ma, L., Yang, J., Jiang, J., Yang, S., Huang, J., Wu, M., Fang, L., Lu, Y., Luo, A., Wang, S. Tags: Original Articles Source Type: research
