The Role of Angiogenesis in the Persistence of Chemoresistance in Epithelial Ovarian Cancer

Conclusion:
Cisplatin- and taxotere-resistant EOC cells are characterized by lower VEGF, VEGF receptors, and HIF-1α, and decreased angiogenesis. These findings may indicate a decrease in drug delivery at the tumor site, hence allowing the persistence of chemoresistant EOC cells.

Source: Reproductive Sciences - October 11, 2016 Category: Reproduction Medicine Authors: Nusrat, O., Belotte, J., Fletcher, N. M., Memaj, I., Saed, M. G., Diamond, M. P., Saed, G. M. Tags: Original Articles Source Type: research