Postepy higieny i medycyny doswiadczalnej This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Postepy Hig Med Dosw 2017; 71:466-484 "Adipose tissue – morphological and biochemical characteristic of different depots"
Adipose tissue is an organ that performs a lot of significant physiological functions, which is why its excess in the body results in pathological states in many of its organs and systems. Adipose tissue is not only a tissue which stores fat and plays a protective role. It is an important endocrine organ where signals sent from different tissues are generated and integrated. Adipose tissue is both morphologically and physiologically differentiated. However, due to their plasticity, adipocytes can undergo a transformation and change their structure and metabolism depending on the physiological state of the organism and the ...
Source: Postepy higieny i medycyny doswiadczalnej - June 8, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:454-465 "Mitochondria: Target organelles for estrogen action"
Estrogens belong to a group of sex hormones, which have been shown to act in multidirectional way. Estrogenic effects are mediated by two types of intracellular receptors: estrogen receptor 1 (ESR1) and estrogen receptor 2 (ESR2). There are two basic mechanisms of estrogen action: 1) classical-genomic, in which the ligand-receptor complex acts as a transcriptional factor and 2) a nongenomic one, which is still not fully understood, but has been seen to lead to distinct biological effects, depending on tissue and ligand type. It is postulated that nongenomic effects may be associated with membrane signaling and the presence...
Source: Postepy higieny i medycyny doswiadczalnej - June 8, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:446-453 "Immune disorders induced by exposure to pyrethroid insecticides"
Pyrethroids are biocides, which belong to the third generation of insecticides. They are used as biocides, insecticides and medicines. These agents react selectively, because they are less harmful to birds and mammals (due to poor intestinal absorption and rapid detoxification in the body of homeothermic organisms) and they are poisonous for fish and insects. The aim of the article is to present the current state of knowledge on the effects of pyrethroids on the immune system based on the latest scientific research. The mechanism of action of pyrethroids include the delaying closure of voltage- sensitive sodium and chlor...
Source: Postepy higieny i medycyny doswiadczalnej - June 8, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:431-445 "Non-small cell lung cancer – mutations, targeted and combination therapy"
Year after year, a growing number of cases of non-small cell lung cancer (NSCLC), mostly caused by smoking, have been noted. Most patients die because of the late detection of cancer and tumor resistance to treatment with cytostatics. Treatment of patients with advanced NSCLC is impeded by the low sensitivity of the tumor to cytostatic agents and the co-existence of many diseases, which substrate is, like lung cancer, cigarette smoking. Along with the development of molecular biology, targeted therapy has started to be used, affecting specific signaling pathways involved in the processes of oncogenesis. Compounds that inhi...
Source: Postepy higieny i medycyny doswiadczalnej - May 17, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:422-430 "The role of SRSF1 in cancer"
SRSF1 jest wielofunkcyjnym bia ł kiem bior ą cym udzia ł w procesach zwi ą zanych z metabolizmem RNA. Nast ę pstwem zaburze ń ekspresji SRSF1, obserwowanych w wielu typach nowotwor ó w, s ą nieprawid ł owo ś ci w sk ł adaniu pre-mRNA, zmiany stabilno ś ci transkrypt ó w i poziomu translacji onkogen ó w oraz gen ó w supresorowych. Reguluj ą c r ó ż nicowe sk ł adanie transkrypt ó w gen ó w CCND1, RAC1, KLF6, BCL2L1, MCL1 oraz CASP9, SRSF1 indukuje zmiany w cyklu kom ó rkowym, proliferacji i apoptozie. Czynnik SRSF1 wp ł ywa tak ż e na angiogenez ę nowotworow ą i przerzutowanie, m.in. promuj ą c po...
Source: Postepy higieny i medycyny doswiadczalnej - May 17, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:411-421 "Pharmacological features of osthole"
Coumarins are a group of naturally occurring compounds common in the plant world. These substances and their derivatives exhibit a broad range of biological activities. One of the naturally occurring coumarins is osthole, which can most frequently be found in plants of the Apiaceae family. Cnidium monnieri (L.) Cusson ex Juss. Angelica pubescens Maxim. and Peucedanum ostruthium (L.). It has anti-proliferative, anti-inflammatory, anti-convulsant, and antiallergic properties; apart from that, inhibition of platelet aggregation has also been proved. The impact of osthole on bone metabolism has been demonstrated; also its hep...
Source: Postepy higieny i medycyny doswiadczalnej - May 17, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:398-410 "Alzheimer ’ s disease against peptides products of enzymatic cleavage APP protein: Biological, pathobiological and physico-chemical properties of fibrillating peptides"
Various peptides products of enzymatic cleavage of key for Alzheimer ’ s disease Amyloid Precursor Protein (APP) are well known, but still are matter of scientific debate. The A β type products are especially challenging for experimental and medical research. This paper outlines several, still poorly known, biological and medical processes such as peptides biology, i.e., formation, biodistribution, translocation, transport and finally removal from brain compartments and body fluids like Intracellular Fluid (ICF), Cerebrospinal Fluid (CSF), Interstitial Fluid (ISF), blood serum or urine. In addition, the following studie...
Source: Postepy higieny i medycyny doswiadczalnej - May 17, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:380-397 "Invasion and metastasis of tumour cells resistant to chemotherapy"
Metastatic tumours resistant to chemotherapy are the major cause of the clinical failure in the treatment of malignant diseases. It is observed often that drugs active against primary tumours do not exhibit the same efficacy towards metastatic tumour cells having modified signaling pathways. Among cellular factors involved in the development of the metastatic potential of multidrug resistant tumour cells are some oncoproteins, antiapoptotic proteins, mutated suppressor proteins, integrins and CD44 receptor. It was also demonstrated that numerous chemotherapeutics have the effect on the emergence of the metastatic potential...
Source: Postepy higieny i medycyny doswiadczalnej - May 17, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:380-398 "Invasion and metastasis of tumour cells resistant to chemotherapy"
Metastatic tumours resistant to chemotherapy are the major cause of the clinical failure in the treatment of malignant diseases. It is observed often that drugs active against primary tumours do not exhibit the same efficacy towards metastatic tumour cells having modified signaling pathways. Among cellular factors involved in the development of the metastatic potential of multidrug resistant tumour cells are some oncoproteins, antiapoptotic proteins, mutated suppressor proteins, integrins and CD44 receptor. It was also demonstrated that numerous chemotherapeutics have the effect on the emergence of the metastatic potential...
Source: Postepy higieny i medycyny doswiadczalnej - May 9, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:367-379 "The importance of Bordetella pertussis strains which do not produce virulence factors in the epidemiology of pertussis"
Bordetella pertussis strains, which have lost the ability to produce antigens, such as pertactin - Prn, pertussis toxin - Ptx, filamentous haemagglutinin - FHA, fimbriae type 2 and 3 - Fim 2 and 3, tracheal colonization factor - TcfA, have recently been isolated in countries with a high vaccination coverage. The emergence of such isolates might have resulted from B. pertussis natural evolution course or adaptive mechanisms, allowing increased circulation of the pathogen in vaccinated populations. So far, the majority of described mutants were deficient in the Prn production. Prn deficient isolates were found in countries w...
Source: Postepy higieny i medycyny doswiadczalnej - May 9, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:359-366 "The role of oxidative stress in female infertility and in vitro fertilization"
Infertility problem involves many couples of reproductive age. It has been estimated that in Poland 0.7-1.0 million pairs require treatment, while for more than half of them assisted reproduction is the only recommended and effective method. Infertility affects 13 to 15% of the world ’ s population. A major concern is the age-related decline in female fertility even more that often a decision about pregnancy is taken at later age. Recent studies show that increased production of reactive oxygen species is an important factor in etiopathogenesis of pregnancy and affects female reproduction. It was found that oxidative str...
Source: Postepy higieny i medycyny doswiadczalnej - May 9, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:352-358 "Effects of Granulocyte Colony-Stimulating Factor on Opsonin Receptor Expression and Neutrophil Antibacterial Activity in a Mouse Model of Severe Acute Pancreatitis"
The antimicrobial function of neutrophils, which is dependent on opsonin receptors, deteriorates in severe acute pancreatitis (SAP). Granulocyte colony-stimulating factor (G-CSF) putatively enhanced levels of the opsonin receptors CD11b and CD32/16 in healthy human subjects, and provided protection against infection in animal models of SAP. A statistically convincing study of the effect of G-CSF on CD32/16 expression in an SAP model is lacking. We used a mouse model of SAP to investigate the association between G-CSF administration and CD32/16 levels on neutrophils and bacterial translocation. G-CSF or saline was subcutane...
Source: Postepy higieny i medycyny doswiadczalnej - May 9, 2017 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2017; 71:339-351 "Cofilin – a protein controlling dynamics of actin filaments"
Cofilins are evolutionary conserved proteins present in all Eukaryotic cells. Their primary function is dynamic reorganization of actin cytoskeleton. Two cofilin isoforms are known: cofilin 1, present in all studied non-muscle cells and in embryonic muscle cells, and cofilin 2, which dominates in mature skeletal and cardiac muscles. Polypeptide chains of both isoforms fold into a structure homological to a conservative ADF (actin depolymerizing factor) domain, which is characteristic of actin depolymerizing factor. In cofilin molecule two actin-binding sites were found. One site binds monomeric and filamentous actin, the s...
Source: Postepy higieny i medycyny doswiadczalnej - May 9, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:328-338 "Bacteriocins from lactic acid bacteria as an alternative to antibiotics"
Bacteriocins are ribosomally synthesized, proteinaceous substances that inhibit the growth of closely related species through numerous mechanisms. The classification system used in this review divided bacteriocins into four sub-groups based on their size. Currently, there is extensive research focused on bacteriocins and their usage as a food preservative. The increasing incidence of multidrug resistant bacterial pathogens is one of the most pressing medical problems in recent years. Recently, the potential clinical application of LAB (Lactic Acid Bacteria) bacteriocin has been the subject of investigations by many scient...
Source: Postepy higieny i medycyny doswiadczalnej - May 9, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:341-353 "Cofilin – a protein controlling dynamics of actin filaments"
Cofilins are evolutionary conserved proteins present in all Eukaryotic cells. Their primary function is dynamic reorganization of actin cytoskeleton. Two cofilin isoforms are known: cofilin 1, present in all studied non-muscle cells and in embryonic muscle cells, and cofilin 2, which dominates in mature skeletal and cardiac muscles. Polypeptide chains of both isoforms fold into a structure homological to a conservative ADF (actin depolymerizing factor) domain, which is characteristic of actin depolymerizing factor. In cofilin molecule two actin-binding sites were found. One site binds monomeric and filamentous actin, the s...
Source: Postepy higieny i medycyny doswiadczalnej - May 5, 2017 Category: Research Tags: Review article Source Type: research