Postepy higieny i medycyny doswiadczalnej 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Postepy Hig Med Dosw 2016; 70:514-521 "Carbamylation of proteins – mechanism, causes and consequences"
Carbamylation (carbamoylation) is a post-translational modification resulting from the nonenzymatic reaction between isocyanic acid and free functional groups of proteins, in particular with the free amino groups. This reaction alters structural and functional properties of proteins and results in faster aging of proteins.
Urea present in the body can be transformed into cyanate and its more reactive form, isocyanic acid. High concentration of urea is associated with some diseases, especially with chronic renal failure and atherosclerosis. In human tissues, urea and cyanate are in equilibrium in aqueous solutions. Surpris...
Source: Postepy higieny i medycyny doswiadczalnej - July 22, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:459-470 "Leczenie zespo ł u nerczycowego: immuno- czy raczej podocytoterapia?"
Zesp ó ł nerczycowy (ZN) jest to grupa objaw ó w klinicznych b ę d ą cych skutkiem masywnego bia ł komoczu spowodowanego przez uszkodzenie bariery filtracyjnej k ł ę buszk ó w nerkowych. Barier ę t ę stanowi b ł ona podstawna naczy ń kapilarnych wraz z warstw ą kom ó rek ś r ó db ł onka pokrywaj ą c ą jej wn ę trze oraz z warstw ą podocyt ó w po stronie zewn ę trznej. Podocyty s ą nie tylko cz ę ś ci ą filtra k ł ę buszkowego, ale jednocze ś nie reguluj ą wytwarzanie pozosta ł ych element ó w bariery. Integralno ś ć tych kom ó rek jest wi ę c szczeg ó lnie istotna dla zacho...
Source: Postepy higieny i medycyny doswiadczalnej - July 22, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:380-391 "Frankincense – therapeutic properties"
Recently, increasing interest in natural dietary and therapeutic preparations used as dietary supplements has been observed. One of them is frankincense. This traditional medicine of the East is believed to have anti-inflammatory, expectorant, antiseptic, and even anxiolytic and anti-neurotic effects. The present study aims to verify the reported therapeutic properties of Boswellia resin and describe its chemical composition based on available scientific studies. The main component of frankincense is oil (60%). It contains mono- (13%) and diterpenes (40%) as well as ethyl acetate (21.4%), octyl acetate (13.4%) and methylan...
Source: Postepy higieny i medycyny doswiadczalnej - July 22, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:305-312 "Markery zapalenia, aktywacja p ł ytek krwi i zaburzenia krzepni ę cia w chorobach zapalnych jelit"
Inflammatory bowel disease (IBD) includes ulcerative colitis and Crohn ’ s disease. It is a group of chronic disorders characterized by inflammation of the gastrointestinal track with unknown etiology. Currently applied biomarkers include CRP, ESR, pANCA, ASCA, and fecal calprotectin. The etiopathogenesis of IBD is multifactorial. In patients with IBD in inflamed alimentary tract mucosa the number of recruited monocytes and activated macrophages which are source of cytokines. In IBD, the exacerbation is accompanied by thrombocytosis. Platelets play a crucial role in the hemostasis and inflammatory response. Selectins, wh...
Source: Postepy higieny i medycyny doswiadczalnej - July 22, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:219-230 "Aminotransferaza asparaginianowa – kluczowy enzym w metabolizmie og ó lnoustrojowym cz ł owieka"
Aspartate aminotransferase is an organ - nonspecific enzyme located in many tissues of the human body where it catalyzes reversible reaction of transamination. There are two aspartate aminotransferase isoforms - cytoplasmic (AST1) and mitochondrial (AST2), that usually occur together and interact with each other metabolically. Both isoforms are homodimers containing highly conservative regions responsible for catalytic properties of enzyme. The common feature of all aspartate aminotransfeses is Lys – 259 residue covalent binding with prosthetic group - pyridoxal phosphate. The differences in the primary structure of AST...
Source: Postepy higieny i medycyny doswiadczalnej - July 22, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:210-218 "Wegener ’ s granulomatosis and pyoderma gangrenosum – rare causes of facial ulcerations"
This study revealed a similar rate of comorbidity of WG and PG in both genders and an increased incidence of both diseases after the age of 50. Among skin lesions there was a dominance of ulceration, most often deep and painful, covering a large area with the presence of advanced necrosis and destruction of the surrounding tissue. The most common location proved to be the cervical-cephalic area. The most popular treatment included steroids with cyclophosphamide.
Discussion: The rarity of the coexistence of these two diseases results in a lack of effective therapy. In such cases sulfone derivatives are still effective and ...
Source: Postepy higieny i medycyny doswiadczalnej - July 22, 2016 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2016; 70:194-199 "Rola limfocyt ó w IRA B w wybranych procesach zapalnych"
The first report about the discovery of new, previously unknown immune cells named IRA B cells (innate response activator B cells) appeared in 2012. So far, their presence has been verified in both mice and humans. However, IRA B cells belong to the family of B lymphocytes and have a number of characteristics unique to this group of cells. IRA B cells are formed from activated B1a lymphocytes after their contact with a pathogen. B1a lymphocytes mainly reside within body cavities. Activated by the pathogen, they move on into secondary lymphoid organs (spleen, lymph nodes) where they differentiate into IRA B cells. IRA B cel...
Source: Postepy higieny i medycyny doswiadczalnej - July 22, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:95-103 "Galectins in hematological malignancies – role, functions and potential therapeutic targets"
Galectins are a family of lectins characterized by an affinity for β – galactosides through the carbohydrate recognition domain (CRD). The extracellular and intracellular presence of Galectins has been described. Their activity and functions are mainly attributed to cell type. The tumor microenviroment is a complex milieu connected with immunosupression, angiogenesis and hypoxic compartments. The studies of interactions between Glycans – Lectins are highly advanced and promising. We are not able to explain the pathogenesis of many diseases only by protein – protein interactions, that is why in these studies is a ...
Source: Postepy higieny i medycyny doswiadczalnej - July 22, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:67-73 "Znaczenie bia ł ek z rodziny ADAM w nowotworach z ł o ś liwych"
W ostatnich latach pojawia si ę coraz wi ę cej doniesie ń o roli adamalizyn (ADAM) w nowotworach z ł o ś liwych. Dot ą d opisano ponad 30 przedstawicieli tej grupy, z czego prawie 20 wyst ę puje u cz ł owieka. Bia ł ka z rodziny ADAM tworz ą jednorodn ą pod wzgl ę dem strukturalnym grup ę bia ł ek, kt ó re reguluj ą w organizmie cz ł owieka wiele proces ó w, pocz ą wszy od stadium embriogenezy a ż po migracj ę kom ó rkow ą , adhezj ę , fuzj ę kom ó rek. Po ł owa z nich ma aktywno ś ć proteolityczn ą i bierze udzia ł w degradacji macierzy mi ę dzykom ó rkowej oraz rozpadzie niekt...
Source: Postepy higieny i medycyny doswiadczalnej - July 22, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:25-42 "Immune checkpoint ‑ targeted cancer immunotherapies"
Tumor cells may express on their surface various characteristic antigens that can induce antitumor immunity. However, cancer in human body may induce an immunosuppressive microenvironment that limits immune response to its antigens. For many years scientists have tried to develop an immunotherapy which would induce a potent antitumor immune response and lead to an elimination of the disease. One of the most promising immunotherapies is blockade of immune checkpoints, i.e. a group of costimulatory molecules negatively regulating the immune system. Their blockade would overcome immune tolerance in the tumor microenvironment ...
Source: Postepy higieny i medycyny doswiadczalnej - July 22, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:10-13 "Disease duration and age influence CARD15 expression in Crohn ’ s disease"
One of the susceptibility genes in Crohn ’ s disease (CD) is CARD15. Our study examined the relationship between peripheral CARD15 expression and phenotype and duration of CD, treatment methods and inflammatory indices. Sixty patients with CD and 30 healthy volunteers as controls were enrolled in the study. Total RNA was isolated from peripheral blood mononuclear cells (PBMCs) with E.Z.N.A. Total RNA Kit (Omega Bio-tek) then quantitative real-time PCR was performed on the ABI Prism 7900 HT Real-Time PCR System. CARD15 gene expression in PBMCs in CD was significantly higher than in the control group. The highest level of ...
Source: Postepy higieny i medycyny doswiadczalnej - July 22, 2016 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2016; 70:811-819 "New prognostic biomarkers in multiple myeloma"
Multiple myeloma is a malignant neoplastic disease, characterized by uncontrolled proliferation and accumulation of plasma cells in the bone marrow, which is usually connected with production of a monoclonal protein. It is the second most common hematologic malignancy. It constitutes approximately 1% of all cancers and 10% of hematological malignancies. Despite the huge progress that has been made in the treatment of multiple myeloma in the past 30 years including the introduction of new immunomodulatory drugs and proteasome inhibitors, it is still an incurable disease. According to current data, the five-year survival rat...
Source: Postepy higieny i medycyny doswiadczalnej - July 19, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:803-810 "Mobile antibiotic resistance – the spread of genes determining the resistance of bacteria through food products"
In recent years, more and more antibiotics have become ineffective in the treatment of bacterial nfections. The acquisition of antibiotic resistance by bacteria is associated with circulation of genes in the environment. Determinants of antibiotic resistance may be transferred to pathogenic bacteria. It has been shown that conjugation is one of the key mechanisms responsible for spread of antibiotic resistance genes, which is highly efficient and allows the barrier to restrictions and modifications to be avoided. Some conjugative modules enable the transfer of plasmids even between phylogenetically distant bacterial specie...
Source: Postepy higieny i medycyny doswiadczalnej - July 7, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:797-802 "Hepatoblastoma Biology Using Isotope Ratio Mass Spectrometry: Utility of a Unique Technique for the Analysis of Oncological Specimens"
Conclusions: The prognosis in liver tumors cases in children may be challenging particularly because of the lack of versatile methods of its evaluation. Isotope ratio mass spectrometry allows one to determine the difference between hepatoblastoma histological subtypes and clearly indicates the cases with the best outcome. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - July 7, 2016 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2016; 70:787-796 "Alzheimer’s disease against peptides products of enzymatic cleavage of APP protein. Forming and variety of fibrillating peptides – some aspects"
Various and different peptides products resulting from enzymatic protein cleavage of Amyloid Precursor Proteins (APP) are the main agents in the pathophysiology of Alzheimer’s disease (AD). Although relatively well-known, they still arouse interest leading to further intense and wide-ranging research. Their biology and physico-chemical properties still are challenging for basic, experimental research and are matter of scientific debate. The APP itself and its functions are still somewhat enigmatic and therefore it is also called the All Purpose Protein. Apart from well known amyloidogenic and antiamyloidogenic (non-amylo...
Source: Postepy higieny i medycyny doswiadczalnej - July 7, 2016 Category: Research Tags: Review article Source Type: research
