Postepy higieny i medycyny doswiadczalnej 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Postepy Hig Med Dosw 2017; 71:176-185 "Tolerance of monocytes and macrophages in response to bacterial endotoxin"
Monocytes belong to myeloid effector cells, which constitute the first line of defense against pathogens, also called the nonspecific immune system and play an important role in the maintenance of tissue homeostasis. In response to stimulation, monocytes differentiate into macrophages capable of microorganism phagocytosis and secrete factors that play a key role in the regulation of immune responses. However excessive exposure of monocytes/macrophages to the lipopolysaccharide (LPS) of Gram negative bacteria leads to the acquisition of immune tolerance by these cells. Such state results from disruption of different biologi...
Source: Postepy higieny i medycyny doswiadczalnej - March 7, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:170-175 "Metformin – its potential anti-cancer and anti-aging effects"
The generally accepted mechanism of metformin ’ s effect is stimulation of adenosine monophosphate (AMP)-activated protein kinase (AMPK). AMPK is directly activated by an increase in AMP:ATP ratio in metabolic stress conditions including hypoxia and glucose deprivation. Lately, many novel pathways, besides AMPK induction, have been revealed, which can explain some of metformin ’ s beneficial effects. It may help to identify new targets for treatment of diabetes and metabolic syndrome. Moreover, metformin is now attracting the attention of researchers in fields other than diabetes, as it has been shown to have anti-canc...
Source: Postepy higieny i medycyny doswiadczalnej - March 2, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:162-169 "Endothelial integrity may be regulated by a specific antigen via an IgE-mediated mechanism"
Conclusions: The presence of Fc ε RI and Fc ε RII may allow the human vascular endothelium to respond to a specific antigen by increasing its integrity via an IgE-mediated mechanism. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - March 2, 2017 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2017; 71:149-161 "Cancer chemoprevention – selected molecular mechanisms"
The effect of diet on cancer formation and prevention of carcinogenesis has attracted considerable attention for years and is the subject of several studies. Some components of the daily diet, such as resveratrol, curcumin, genistein, gingerol, can significantly reduce the risk of cancer or affect the rate of tumor progression. Cancer chemoprevention assumes the use of natural or synthetic biologically active substances in order to prevent, inhibit or reverse the progression of cancer. There are many biologically active compounds in several natural products, i.e. garlic, ginger, soy, curcuma, tomatoes, cruciferous plants o...
Source: Postepy higieny i medycyny doswiadczalnej - March 2, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:137-148 "Ibudilast: a non ‑ selective phosphodiesterase inhibitor in brain disorders"
Ibudilast (IBD) is a non ‑ selective (3, 4, 10, 11) phosphodiesterase (PDE) inhibitor, used mainly as a bronchodilator for the treatment of bronchial asthma. PDE play a central role in cellular function (e.g. differentiation, synaptic plasticity and inflammatory response) by metabolizing cyclic nucleotides. The results from preclinical and clinical studies indicate that IBD has a broader range of action through suppression of pro ‑ inflammatory cytokines (IL ‑ 6, IL ‑ 1 β , TNF ‑ α ), toll ‑ like receptor 4 blockade (TLR ‑ 4), inhibition of a macrophage migration inhibitory factor (MIF), up ‑ regulation t...
Source: Postepy higieny i medycyny doswiadczalnej - March 2, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:129-136 "Pharmaceutical applications of graphene"
Nowadays, dynamic development in nanotechnological sciences is observed. Nanoparticles are frequently used in medicine and pharmacy as delivery systems for different kinds of active substances. One of the latest developed substances, with an unusually wide scope of utility, is graphene. The ways of its use in different fields of industry, not only pharmaceutical and medical, have been a subject of study for many research groups since the moment of its development in 2004. Graphene in pure form is highly hydrophobic. However, the presence of defects on its surface allows chemical modifications to be made, e.g. introduction ...
Source: Postepy higieny i medycyny doswiadczalnej - February 15, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:118-128 "Mitochondria in brain hypoxia"
Neurons vary widely in shape, size, type of neurotransmitters and number of synapses. Their common characteristic is a very high sensitivity to changes in oxygen concentration. The consequence of hypoxia is to launch a series of biochemical reactions called the ischemic cascade. The term is a bit misleading, because it suggests that there is a succession of events, in a linear fashion. In fact, the ischemic cascade involves very complex processes that take place simultaneously and interact with each other. The key role in neuronal responses to hypoxia is played by changes related to mitochondria, which occur immediately af...
Source: Postepy higieny i medycyny doswiadczalnej - February 15, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:110-117 "The role of chemerin in human disease"
Adipose tissue is not merely a storage depot of triacylglycerols but also a major endocrine organ. Its cells, including adipocytes, synthesize and secrete a range of biologically active molecules termed adipokines. Adipokines that display the properties of cytokines are often called adipocytokines. In recent years there has been increasing interest in a new adipokine called chemerin. Chemerin is a protein synthesized mostly by the adipose tissue and the liver as inactive pre ‑ pro ‑ chemerin. After the intracellular hydrolytic cutting off of the 20 ‑ amino ‑ acid N ‑ terminal polypeptide, it is secreted into the ...
Source: Postepy higieny i medycyny doswiadczalnej - February 15, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:98-109 "The role of metallothionein in oncogenesis and cancer treatment"
Metallothionein is cysteine-rich low molecular mass protein. The involvement of MT in many physiological and pathophysiological processes such as apoptosis, proliferation, angiogenesis, and the detoxification of heavy metals suggested participation of this protein in carcinogenesis and tumor therapy.
Depending on the type of tissue and classification of carcinoma various it was observed relation between MT expression and tumor type, stage, grade, poor prognosis and body resistance to radiotherapy and chemotherapy. MT in tumor cell plays important role in defense mechanism against the effect of radiation by inhibiting the ...
Source: Postepy higieny i medycyny doswiadczalnej - February 14, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:92-97 "HPV Vaccinations in Lublin Region, Poland"
Conclusions: Among the total number of girls vaccinated against HPV, those vaccinated within prophylactic programmes carried out by territorial self-government units made up a considerable percentage. Programmes of free preventive vaccinations against HPV began in 4 cities in the Lublin Region, but are continued in only 2. Long-term observation of girls subjected to vaccinations from the aspect of duration of maintaining immunity after vaccination should become an important element of the performance of health programmes concerning vaccinations against HPV. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - February 14, 2017 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2017; 71:78-91 "Pathogenic factors of Pseudomonas aeruginosa – the role of biofilm in pathogenicity and as a target for phage therapy"
Pseudomonas aeruginosa is an opportunistic pathogen that can cause several acute and chronic infections in humans, and it has become an important cause of nosocomial infections and antibiotic resistance. Biofilm represents an important virulence factor for these bacteria, plays a role in P. aeruginosa infections and avoidance of immune defence mechanisms, and has the ability to protect the bacteria from antibiotics. Alginate, Psl and Pel, three exopolysaccharides, are the main components in biofilm matrix, with many biological functions attributed to them, especially with respect to the protection of the bacterial cell fro...
Source: Postepy higieny i medycyny doswiadczalnej - February 14, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:69-77 "Leprosy – one of the many forgotten tropical diseases"
Leprosy or Hansen disease is caused by an infection of Mycobacterium leprae. The large number of undetected cases (2000-2012 years 4 mln people) remains a threat to the elimination of leprosy. Leprosy is an unheard in Poland and generally is considered a condition so “ exotic ” that it is not worth to spend more attention to it. Forgotten disease in developed countries still thrives in an environment of poor and uneducated. Regardless of the conclusion that in the 21st century none infectious disease should not be treated as a disease on the designated regions of the world, other than our own, it should be recalled tha...
Source: Postepy higieny i medycyny doswiadczalnej - February 14, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:57-68 "The role of oxidative stress and NADPH oxidase in the pathogenesis of atherosclerosis"
Reactive oxygen species (ROS) play a key role in the pathogenesis of atherosclerosis. The main mechanisms which are involved are low-density lipoprotein oxidative modification, inactivation of nitric oxide and modulation of redox-sensitive signaling pathways. ROS contribute to several aspects of atherosclerosis including endothelial cell dysfunction, monocyte/macrophage recruitment and activation, stimulation of inflammation, and inducing smooth muscle cell migration and proliferation. NADPH oxidase is the main source of ROS in the vasculature. This enzyme consists of a membrane-bound heterodimer of gp91phox and p22phox, c...
Source: Postepy higieny i medycyny doswiadczalnej - January 28, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:47-56 "Molecular diagnostics of periodontitis"
The microorganisms that form dental plaque are the main cause of periodontitis. Their identification and the understanding of the complex relationships and interactions that involve these microorganisms, environmental factors and the host ’ s health status enable improvement in diagnostics and targeted therapy in patients with periodontitis. To this end, molecular diagnostics techniques (both techniques based on the polymerase chain reaction and those involving nucleic acid analysis via hybridization) come increasingly into use. On the basis of a literature review, the following methods are presented: polymerase chain re...
Source: Postepy higieny i medycyny doswiadczalnej - January 28, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2017; 71:40-46 "Clinical usefulness of serum free light chains measurement in patients with multiple myeloma: comparative analysis of two different tests"
Conclusions: There was no strong correlation or concordance between the two assays, and the sensitivity in terms of sFLC detection was different. This may cause problems when diagnosis of sCR is considered. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - January 22, 2017 Category: Research Tags: Original article Source Type: research
