Postepy higieny i medycyny doswiadczalnej 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Postepy Hig Med Dosw 2016; 70:1362-1366 "Role of circulating microRNA in hemodialyzed patients"
MicroRNA (miRNA) belongs to the family of non-coding RNAs, which posttranscriptionally regulate gene function. Moreover, accumulating evidence points to an essential role of miRNAs in development and monitoring of kidney disease, though the role of particular miRNAs in patients undergoing hemodialysis is still unclear. This might have consequences. It is possible that measuring a single miRNA in hemodialyzed patients may not provide adequate information about development of many pathological processes. The goal of this review is to highlight the current knowledge in the field of miRNAs, with a special emphasis on their cir...
Source: Postepy higieny i medycyny doswiadczalnej - January 2, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:1343-1361 "Phospholipids and products of their hydrolysis as dietary preventive factors for civilization diseases"
The results of numerous epidemiological studies indicate that phospholipids play an important role in the prevention of chronic diseases faced by contemporary society. Firstly, these compounds are responsible for the proper functioning of cell membranes, by ensuring liquidity and permeability, which is pivotal for normal activity of membrane proteins, including receptors. These mechanisms are at the core of prevention of cancer, autoimmune or neurological disorders. Secondly, structure and properties of phospholipids cause that they are highly available source of biologically active fatty acids. Thirdly, also products of e...
Source: Postepy higieny i medycyny doswiadczalnej - January 2, 2017 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:1331-1342 "Pathophysiology and molecular basis of selected metabolic abnormalities in Huntington ’ s disease"
Huntington ’ s disease (HD) is an incurable, devastating neurodegenerative disease with a known genetic background and autosomally dominant inheritance pattern. HTT gene mutation (mHTT) is associated with polymorphic fragment elongation above 35 repeats of the CAG triplet. The mHTT product is an altered protein with a poly-Q elongated fragment, with the highest expression determined in the central nervous system (CNS) and with differentiated expression outside the CNS. A drastic loss of striatal and deeper layers of the cerebral cortex neurons was determined in the CNS, but muscle and body weight mass loss with dysfuncti...
Source: Postepy higieny i medycyny doswiadczalnej - December 31, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:1321-1330 "Prognostic value of thymidine kinase activity in patients with chronic lymphocytic leukemia"
Thymidine kinase (TK) activity is a marker of biological activity that allows the indolent and aggressive forms of chronic lymphocytic leukemia (CLL) to be distinguished. The aims of the study were to determine the relationship between TK activity and clinical status and prognosis, as well as to compare its activity with that of other prognostic and predictive factors. TK activity was measured in patient sera at the time of diagnosis using the DiviTum method, with the mean value being 439 Du/L. A correlation was found between TK activity and risk of disease progression (p=0.045). The optimal discriminative value of TK acti...
Source: Postepy higieny i medycyny doswiadczalnej - December 31, 2016 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2016; 70:1309-1320 "Cannabinoids – a new weapon against cancer?"
Cannabis has been cultivated by man since Neolithic times. It was used, among others for fiber and rope production, recreational purposes and as an excellent therapeutic agent. The isolation and characterization of the structure of one of the main active ingredients of cannabis – Δ 9 – tetrahydrocannabinol as well the discovery of its cannabinoid binding receptors CB1 and CB2, has been a milestone in the study of the possibilities of the uses of Cannabis sativa and related products in modern medicine. Many scientific studies indicate the potential use of cannabinoids in the fight against cancer. Experiments carried ou...
Source: Postepy higieny i medycyny doswiadczalnej - December 29, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:1300-1308 "Sialic acids in squamous cell carcinoma of the head and neck"
Altered glycosylation is a universal characteristic of cancer cells, and various types of glycan structures are well ‑ known markers of tumor progression and invasion. The present article discusses this aspect of the role of sialic acid, biosynthesis of sialylglycoconjugates and the genetic basis of its disorder, as well as the effects and the correlation between altered sialylation and clinical prognosis in head and neck squamous cell carcinoma (HNSCC).
Only a few studies concerning the level of sialic acid in head and neck tumors have been conducted so far. The conclusions of the published reports dedicated to that pr...
Source: Postepy higieny i medycyny doswiadczalnej - December 28, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:1286-1299 "The role of YKL-40 in a cancerous process"
YKL-40 is a secretory protein secreted among others by tumor cells and tumor-associated macrophages. Due to the structural homology this protein was classified to chitinases family CLP (chitinase – like protein) and to 18 of glycosyl hydrolase family, but it has no catalytic function. Elevated levels of YKL-40 in serum is observed in the inflammatory diseases of various aetiology and in cancers, such as breast, ovarian, colon or lung. The results of many studies suggest a significant relationship of YKL-40 with progression of cancer: incidence of metastases, shorter relapse-free survival and shorter overall survival. It ...
Source: Postepy higieny i medycyny doswiadczalnej - December 28, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:1276-1285 "Cyclic guanosine monophosphate in the regulation of the cell function"
Intracellular concentration of cGMP depends on the activity of guanylate cyclase, responsible for its synthesis, on the activity of cyclic nucleotide degrading enzymes - phosphodiesterases (PDEs). There are two forms of guanylate cyclase: the membrane-bound cyclase and the soluble form. The physiological activators of the membrane guanylate cyclase are natriuretic peptides (NPs), and of the cytosolic guanylate cyclase - nitric oxide (NO) and carbon monoxide (CO). Intracellular cGMP signaling pathways arise from its direct effect on the activity of G protein kinases, phosphodiesterases and cyclic nucleotide dependent cation...
Source: Postepy higieny i medycyny doswiadczalnej - December 28, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:1267-1275 "Retinol-binding protein 4 (RBP4) as the causative factor and marker of vascular injury related to insulin resistance"
This article summarizes the current state of knowledge on the potential role of RBP4 in the pathogenesis of cardiovascular diseases, particularly related to insulin resistance. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - December 21, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:1259-1266 "Microevolution of BCG substrains"
Tuberculosis was, and still is, one of the main causes of morbidity and mortality in the world. Thus it still remains a public health priority. Nonetheless, without a newly developed vaccine, it is rather unlikely to be easily resolved. The only available vaccine against tuberculosis (BCG) has been used for nearly 100 years. Currently a variety of BCG substrains are used by many manufacturers in the world. All these substrains were obtained from a single parental strain of Mycobacterium bovis. Attempts to explain the complete mechanisms of attenuation, as well as tracing the microevolution resulting from the different dist...
Source: Postepy higieny i medycyny doswiadczalnej - December 21, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:1245-1258 "Insulin resistance and chronic inflammation"
Insulin resistance is a condition of reduced biological response to insulin. Growing evidence indicates the role of the chronic low-grade inflammatory response in the pathogenesis of insulin resistance. Adipose tissue in obesity is characterized by increased lipolysis with the excessive release of free fatty acids, and is also a source of proinflammatory cytokines. Both these factors may inhibit insulin action. Proinflammatory cytokines exert their effect by stimulating major inflammatory NF κ B and JNK pathways within the cells. Inflammatory processes in other insulin responsive tissues may also play a role in inducing i...
Source: Postepy higieny i medycyny doswiadczalnej - December 21, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:1229-1244 "Programmed cell death – strategy for maintenance cellular organisms homeostasis"
This article shows: the occurrence of PCD during animals and plants ontogenesis, classification of cell death types in these organisms with description of autophagy, apoptosis and necrotic cell death and with discussion on plant cell death by apoptosis. The role of Bcl-2 protein and other proteins involved in the regulation of apoptosis induction and detection in the plant ’ s (whose genomes do not encode these proteins) proteins of analogous function is also discussed. The paper also presents the effects of the expression of animals pro- and anti-apoptotic genes transformed into yeast and plants, and the use of transfor...
Source: Postepy higieny i medycyny doswiadczalnej - December 21, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:1220-1228 "Transformation of medicinal plants using Agrobacterium tumefaciens"
For many years attempts are made to develop efficient methods for transformation of medicinal plants via Agrobacterium tumefaciens. It is a soil bacteria which possess a natural ability to infect plants in places of injures which results in arise of cancerous growths (crown gall). This is possible thanks a transfer of fragment of Ti plasmid into plant cells and stable integration with a plant genome. Efficiency of medicinal plant transformation depends on many factors for example: Agrobacterium strain, methods and procedures of transformation as well as on plant species, type and age of the explants and regeneration condit...
Source: Postepy higieny i medycyny doswiadczalnej - December 21, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:1206-1219 "Nuclear matrix – structure, function and pathogenesis"
The nuclear matrix (NM), or nuclear skeleton, is the non-chromatin, ribonucleoproteinaceous framework that is resistant to high ionic strength buffers, nonionic detergents, and nucleolytic enzymes. The NM fulfills a structural role in eukaryotic cells and is responsible for maintaining the shape of the nucleus and the spatial organization of chromatin. Moreover, the NM participates in several cellular processes, such as DNA replication/repair, gene expression, RNA transport, cell signaling and differentiation, cell cycle regulation, apoptosis and carcinogenesis. Short nucleotide sequences called scaffold/matrix attachment ...
Source: Postepy higieny i medycyny doswiadczalnej - December 20, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:1198-1205 "Anti ‑ cytokine therapy for psoriasis – not only TNF ‑ α blockers. Overview of reports on the effectiveness of therapy with IL ‑ 12/IL ‑ 23 and T and B lymphocyte inhibitors"
TNF ‑ α inhibitors – infliximab, etanercept and adalimumab – can be used in the treatment of psoriasis vulgaris and psoriatic arthritis, along with other inhibitors of proinflammatory cytokines, such as interleukin ‑ 12 (IL ‑ 12) and IL ‑ 23.
This paper presents the results of research on the use of biological drugs other than the tumor necrosis factor blockers (TNF ‑ α ), namely inhibitors of IL ‑ 12 and IL ‑ 23 (ustekinumab), T ‑ cell inhibitors (alefacept and efalizumab), B ‑ cell inhibitors (rituximab), anti ‑ IL ‑ 17 agents (secukinumab, ixekizumab, and brodalumab) and IL23p19 inhibitors (...
Source: Postepy higieny i medycyny doswiadczalnej - December 20, 2016 Category: Research Tags: Review article Source Type: research
