Postepy higieny i medycyny doswiadczalnej 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Postepy Hig Med Dosw 2015; 69:1423-1434 "Multifunctional ligands – a new approach in the search for drugs against multi-factorial diseases"
Selective drugs directed at a single biological target often prove ineffective in the treatment of diseases with a complex pathomechanism, e.g. Alzheimer’s disease (AD). This situation prompts researchers to design multi-target-directed ligands (MTDLs), capable of interacting with a number of selected biological targets. The paper outlines the concept of the multi-targetdirected ligand design and examples of its use in the search of a cure for AD. In the knowledgebased approach for designing MTDLs, selective ligands of different targets are combined in one molecule. In the screening-based approach, libraries of compounds...
Source: Postepy higieny i medycyny doswiadczalnej - January 14, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2015; 69:1411-1422 "Viral transfer of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in gene therapy"
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces carcinoma cell death through the extrinsic pathway of apoptosis. Preclinical trials of gene therapy have been conducted using viral transfer of the TRAIL transgene into prostate, bladder, breast, kidney, liver, non-small cell lung cancer and also glioblastoma cells. Experiments in vitro demonstrated the extensive apoptosis of target cells as well as frequent disease regression or remission. TRAIL transfer did not show any side effects, opposite to chemotherapy. Encouraging results of TRAIL-related gene therapy were observed in rheumatoid ar...
Source: Postepy higieny i medycyny doswiadczalnej - January 14, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2015; 69:1405-1410 "Evaluation of effect of selected trace elements on dynamics of sperm dna fragmentation"
Discussion: Reports in the literature which concern the effect of trace elements on human reproduction are equivocal. The present study confirmed an unfavourable effect, especially that of lead, on the dynamics of sperm DNA fragmentation; however, these studies need to be expanded and continued in the future. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - January 14, 2016 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2015; 69:1384-1404 "Immunological mechanisms involved in obesity and their role in metabolic syndrome"
In the past 50 years, the occurrence of human obesity has risen dramatically across the globe. The WHO reported that at least 1.9 billion (1.9 × 109) adults are overweight and 600 million are obese, and the numbers are expected to rise dramatically in the future without intervention. The recent increase in human obesity is caused by increased energy intake and reduced energy expenditure that results in a massive increase in adipose tissue, which is generally harmful to our health. Indeed, the increase in human obesity is strongly associated with an increase in many diseases such as type 2 diabetes (T2D), biliary disease, ...
Source: Postepy higieny i medycyny doswiadczalnej - December 29, 2015 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2015; 69:1371-1383 "TET proteins and epigenetic modifications in cancers"
Epigenetic modifications, including DNA methylation and histone modifications, are involved in regulation of gene expression, and alterations in these modifications are implicated in cancer onset and progression. The specific pattern of DNA methylation depends on the balance between methylation and demethylation processes. Recent studies have shown that TET proteins play a key role in DNA demethylation. TET proteins (TET1, TET2, TET3) are iron(II) and α-ketoglutarate dependent dioxygenases, and their enzymatic activity involves hydroxylation of 5-methylcytosine to 5-hydroxymethylcytosine and further to 5-formylcytosine an...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2015; 69:1364-1370 "Comorbidities as risk factors of chronic kidney disease in HIV-infected persons"
Significant survival prolongation in HIV-infected patients due to effective antiretroviral therapy is connected with increasing prevalence of chronic non-infective diseases in this population, among them chronic kidney disease. The pathogenesis of kidney disease in the setting of HIV includes conditions specific for HIV infection: direct effect of the virus, stage of immunodeficiency and drug toxicity. Chronic comorbidities, such as diabetes mellitus, hypertension, and hyperlipidemia, are additional significant risk factors of kidney disease. In HIV-infected individuals some distinct features of these conditions are observ...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2015; 69:1353-1363 "Programmed necrosis and necroptosis – molecular mechanisms"
Programmed necrosis has been proven vital for organism development and homeostasis maintenance. Its regulatory effects on functional activity of the immune system, as well as on pathways regulating the death mechanisms in cells with diminished apoptotic activity, including malignant cells, have been confirmed. There is also increasing evidence indicating necrosis involvement in many human pathologies. Contrary to previous beliefs, necrosis is not only a passive, pathological, gene-independent process. However, the current knowledge regarding molecular regulation of programmed necrosis is scarce. In part this is due to the ...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2015; 69:1349-1352 "Prevalence of human papillomavirus and herpes simplex virus in amniotic fluid from pregnant women of Eastern Poland"
Conclusion: Our investigation did not confirm the prenatal transmission of HPV and HSV to the amniotic fluid. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2015; 69:1331-1348 "Neurofibromin – protein structure and cellular functions in the context of neurofibromatosis type I pathogenesis"
Neurofibromatosis type I (NF1) is multisystemic disease characterized by pigmentary skin changes, increased susceptibility to tumor formation, neurological deficits and skeletal defects. The disease is a monogenic, autosomal dominant disorder, caused by the presence of mutations in the NF1 gene encoding neurofibromin – a multifunctional regulatory protein. The basic function of neurofibromin protein is modulation of the RAS protein activity necessary for regulation of cell proliferation and differentiation by the RAS/MAPK and RAS/PI3K/AKT signal transduction pathways. In addition, neurofibromin is a regulator of adenylat...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2015; 69:1325-1330 "Skin diseases associated with hepatitis C virus"
Chronic hepatic diseases caused by HBV or HCV infection not always demonstrate evident clinical symptoms of liver disease. Non-specific extrahepatic symptoms mainly skin leasions are helpful for establishing the proper diagnosis. This review illustrates the pathogenesis, epidemiology and clinical manifestations of HBV and HCV infections with a special attention to skin signs and symptoms which can associate these infections. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2015; 69:1313-1324 "Trastuzumab – a monoclonal antibody – and dendrimers in a targeted therapy for breast cancer"
Breast cancer is the most frequently occurring cancer in women. It has been confirmed that approximately 30% of patients have overexpression of human epidermal growth factor 2 (HER2) on the surface of tumor cells. Trastuzumab – a recombinant, humanized monoclonal antibody – is directed against this receptor. Its use in traditional chemotherapy (with anthracyclines or taxanes) causes an increase of therapy efficiency. However, the systemic toxicity of the anticancer drugs is still a serious problem. Therefore, new solutions are sought, especially in the field of selective drug transport to tumor cells. Dendrimers are co...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2015; 69:1299-1312 "Immunosuppression – tough ally in torrid time"
Immunosuppression is a condition characterized by weakened or inhibited immune response. It occurred both in humoral and cellular response. This is related to the variable levels of deficiency for each antibody class (IgG, IgM, IgA) and a decrease in the number and function of immune cells, mainly T cells which results in the inhibition of cytokine production, signaling transduction and clonal expansion. Immunosuppressive therapy is used in many fields of medicine, such as transplantology, oncology, autoimmune disorders. Immunosuppression can be induced in several ways, by the surgical resection of the organs of the immune...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2015; 69:1291-1298 "Activity of JAK/STAT and NF-kB in patients with axial spondyloarthritis"
Conclusions: In the group of patients with axSpA compared with the control group, higher expression of the transcription factors STAT and NF-κB as well as JAK3 was observed. Due to its crucial roles in inflammation and autoimmunity, STAT4 may have promise as an effective therapeutic target for axSpA. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2015; 69:1275-1290 "Ovarian cancer – from biology to clinic"
Ovarian cancer is the most frequent cause of deaths from among gynecologic malignancies. Due to its asymptomatic development the disease is frequently diagnosed at an advanced, incurable stages. Although ovarian cancers usually respond well to the first line chemotherapy based on platinum compounds and taxanes, majority of patients develop recurrence and chemo-resistance. Despite many years of studies there is still lack of reliable diagnostic markers as well as other diagnostic methods enabling early detection and suitable for screening. Thus, current studies are aimed on finding new biomarkers with diagnostic, prognostic...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2015; 69:1268-1274 "Prognostic significance of MCM 2 and Ki-67 in neuroblastic tumors in children"
Discussion: The presented research shows that MCM 2 may have prognostic significance in neuroblastic pediatric tumors and as a potential prognostic factor could be the starting point of new individualized therapy. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Original article Source Type: research
