Postepy higieny i medycyny doswiadczalnej This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Postepy Hig Med Dosw 2016; 70:435-447 "Association between selected gene polymorphisms and statin metabolism, risk of ischemic stroke and cardiovascular disorders"
We present available data of SNPs in regard to the most significant and promising proteins such as cytochrome P450, ATPase superfamily, organic anion transporter family, apolipoprotein E, lipoprotein-associated phospholipase A2, lipoprotein(a), LDLR, proprotein convertase subtilisin/kexin type 9, HMGCR, and CETP. A presentation of particular SNPs may help in future studies to aim for individual and thus more effective statin therapy in stroke patients. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - May 5, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:425-434 "Drugs affecting the incretin system and renal glucose transport: do they meet the expectations of modern therapy of type 2 diabetes?"
Agents introduced into therapy of type 2 diabetes in the last few years are still the subject of numerous clinical and experimental studies. Although many studies have been completed, we still do not know all aspects of these drugs’ action, especially the long-term effects of their use. Most questionable is their impact on the processes of cell proliferation, on the cardiovascular and immune systems, on lipids and uric acid metabolism. A summary of the most important observations on the use of three groups of new drugs – analogs of glucagon-like peptide 1 (GLP-1), inhibitors of dipeptidyl peptidase IV (DPPIV) and inhib...
Source: Postepy higieny i medycyny doswiadczalnej - May 4, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:420-424 "Case control study of ANKK1 Taq 1A polymorphism in patients with alcohol dependence classified according to Lesch’s typology"
Conclusions:Lesch’s typology is a clinical consequence of the disease, and its phenotypic description is too complex for simple genetic analysis. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - May 4, 2016 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2016; 70:410-419 "Juvenile idiopathic arthritis and oral health"
Juvenile idiopathic arthritis (JIA) is the most common autoimmune inflammatory disease of connective tissue in children. It is characterized by progressive joint destruction which causes preserved changes in the musculoskeletal system. The literature describes fully clinical symptoms and radiological images in different subtypes of JIA. However, there is still a limited number of studies reporting on the medical condition of the oral cavity of ill children. JIA can affect hard and soft tissues of the oral cavity by: the general condition of the child’s health, arthritis of the upper limbs, as the result of the pharmacoth...
Source: Postepy higieny i medycyny doswiadczalnej - May 4, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:400-409 "The use of oligonucleotide aptamers in cancer therapy"
Aptamers are a new class of molecules which originated in the 1990s. They are usually RNA or DNA oligonucleotides, the length of which ranges between 20 and 80 nt. They are produced using the SELEX method that allows one to obtain aptamers that bind to virtually any molecule of interest, providing a high specificity. Aptamers are an alternative to antibodies because on the one hand, their sensitivity is at a similar or sometimes even higher level, while on the other hand they do not show immunogenicity, and may be synthesized in vitro. To date, a broad range of different applications of aptamers has been described: as comp...
Source: Postepy higieny i medycyny doswiadczalnej - May 4, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:392-399 "The percentage of iNKT cells among other immune cells at various clinical stages of laryngeal cancer"
Conclusions: Our study confirmed that laryngeal cancer cells exert a strong suppressor effect on the immune system of the host. This is reflected by a decrease in the percentage of iNKT cells that are capable of cancer cell elimination, and a concomitant increase in the percentage of Tregs. However, further studies are needed in order to explain the underlying mechanisms of immunosuppression and understand interactions between immune and cancer cells. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - April 29, 2016 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2016; 70:380-391 "Frankincense – therapeutic properties"
Recently, increasing interest in natural dietary and therapeutic preparations used as dietary supplements has been observed. One of them is frankincense. This traditional medicine of the East is believed to have anti-inflammatory, expectorant, antiseptic, and even anxiolytic and anti-neurotic effects. The present study aims to verify the reported therapeutic properties of Boswellia resin and describe its chemical composition based on available scientific studies. The main component of frankincense is oil (60%). It contains mono- (13%) and diterpenes (40%) as well as ethyl acetate (21.4%), octyl acetate (13.4%) and methylan...
Source: Postepy higieny i medycyny doswiadczalnej - April 27, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:367-379 "The development of methods for obtaining monoclonal antibody-producing cells"
Monoclonal antibodies (mAbs) are biomolecules of great scientific and practical significance. In contrast to polyclonal antibodies from immune sera, they are homogeneous and monospecific, since they are produced by hybridoma cells representing a clone arising from a single cell. The successful technology was described for the first time in 1975; the inventors were later awarded the Nobel Prize. Currently, mAbs are broadly used as a research tool, in diagnostics and medicine in particular for the treatment of cancer or in transplantology. About 47 therapeutics based on monoclonal antibodies are now available in the US and E...
Source: Postepy higieny i medycyny doswiadczalnej - April 27, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:360-366 "The role of inflammation in colon cancer pathogenesis"
The results of the latest research more and more bind development of neoplasms with the chronic inflammation. Inflammatory process creates microenvironment promoting development of neoplasms; as a result, malignant process start to develop in places, where chronic inflammation proceeds or regeneration of tissues takes place. Inflammatory cells not only create suitable microenvironment for development of neoplasms, but also excrete number of cytokines and growth factors promoting survival of a neoplasmatic cell and avoiding its apoptosis, promoting neoangiogenesis and metastases formation. Moreover, cytokines and other pro-...
Source: Postepy higieny i medycyny doswiadczalnej - April 27, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:349-359 "Consequences of extrahepatic manifestations of hepatitis C viral infection (HCV)"
The hepatitis C virus (HCV) is a primarily hepatotropic virus. However, numerous extrahepatic symptoms are observed in patients chronically infected with HCV, e.g. cryoglobulinemia, lymphoproliferative disorders, kidney diseases, disturbances of the central and peripheral nervous system, thyroid gland, pancreas, lymph nodes and pituitary gland, that develop at various times after the infection. Complex mechanisms underlie these processes, both molecular, related to direct effects of the virus on cells or tissues and indirect mechanisms, resulting from the response of the immune system to infection (via cytokines or oxidati...
Source: Postepy higieny i medycyny doswiadczalnej - April 22, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:349-360 "Consequences of extrahepatic manifestations of hepatitis C viral infection (HCV)"
The hepatitis C virus (HCV) is a primarily hepatotropic virus. However, numerous extrahepatic symptoms are observed in patients chronically infected with HCV, e.g. cryoglobulinemia, lymphoproliferative disorders, kidney diseases, disturbances of the central and peripheral nervous system, thyroid gland, pancreas, lymph nodes and pituitary gland, that develop at various times after the infection. Complex mechanisms underlie these processes, both molecular, related to direct effects of the virus on cells or tissues and indirect mechanisms, resulting from the response of the immune system to infection (via cytokines or oxidati...
Source: Postepy higieny i medycyny doswiadczalnej - April 21, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:337-348 "The cellular receptors of exogenous RNA"
One of the key determinants of survival for organisms is proper recognition of exogenous and endogenous nucleic acids. Therefore, high eukaryotes developed a number of receptors that allow for discrimination between friend or foe DNA and RNA. Appearance of exogenous RNA in cytoplasm provides a signal of danger and triggers cellular responses that facilitate eradication of a pathogen. Recognition of exogenous RNA is additionally complicated by fact that large amount of endogenous RNA is present in cytoplasm Thus, number of different receptors, found in eukaryotic cells, is able to recognize that nucleic acid. First group of...
Source: Postepy higieny i medycyny doswiadczalnej - April 21, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:329-336 "KIM-1 and NGAL as potential biomarkers for the diagnosis and cancer progression"
On the basis of scientific literature, there is growing evidence that KIM-1 and NGAL are interesting and promising biomarkers not only in acute and chronic inflammatory processes but also in oncogenesis. There are a number of studies which investigate their possible use in diagnosis, treatment and monitoring of therapy effectiveness. The results of recent research suggests that they may play an important role in standard oncology practice. Simultaneous measurement of KIM-1 and NGAL in urine can play a crucial role in carcinogenesis assessment and cancer progression. In the future, they can become rapid diagnostic indicator...
Source: Postepy higieny i medycyny doswiadczalnej - April 18, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:319-328 "Intracellular glutathione level and efflux in human melanoma and cervical cancer cells differing in doxorubicin resistance"
Discussion: The obtained results seem to refute the hypothesis of a central role of GSH in DOX resistance of the tested cells. Despite observations of different effects related to GSH, they do not seem to be essential in terms of DOX resistance. The mechanisms underlying DOX resistance are highly cell-specific. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - April 18, 2016 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2016; 70:313-318 "Influenza surveillance"
Influenza surveillance was established in 1947. From this moment WHO (World Health Organization) has been coordinating international cooperation, with a goal of monitoring influenza virus activity, effective diagnostic of the circulating viruses and informing society about epidemics or pandemics, as well as about emergence of new subtypes of influenza virus type A. Influenza surveillance is an important task, because it enables people to prepare themselves for battle with the virus that is constantly mutating, what leads to circulation of new and often more virulent strains of influenza in human population. As vaccination ...
Source: Postepy higieny i medycyny doswiadczalnej - April 18, 2016 Category: Research Tags: Review article Source Type: research