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Postepy Hig Med Dosw 2015; 69:1259-1267 "Expression of cyclin A in A549 cell line after treatment with arsenic trioxide"
Discussion: Low expression of cyclin A in the A549 cell line may constitute a potential factor determining arsenic trioxide resistance. It could be hypothesized that the observed alterations in cyclin A expression/distribution may correlate well with changes in cell cycle regulation in our model, which in turn determines the outcome of the treatment. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2015; 69:1251-1258 "Retinal degeneration following lead exposure – functional aspects"
We present the most frequent sources of exposure to lead in the environment and the influence on vision, mechanisms leading to the apoptosis of photoreceptor cells, as well as strategies for blocking rod apoptosis. We also present Pb-induced disorders in the calcium metabolism of photoreceptor cells and Ca2+-dependent enzymes. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2015; 69:1245-1250 "Association between ins4436A in 11β-hydroxysteroid dehydrogenase type 1 gene and essential hypertension in Polish population"
Discussion: The cause of essential hypertension has not been fully established, but genetic factors seem to play a very important role. In our study we found that ins4436A in the HSD11B1 gene was associated with essential hypertension in a Polish population. Nevertheless, the impact of ins4436A in the HSD11B1 gene on the occurrence of essential hypertension requires further investigations. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2015; 69:1239-1244 "Dual action of vitamin C versus degradation and supplementation"
The article discusses vitamin C from the point of view of its supplementation with food and in the form of oral supplements. The dual action of vitamin C is connected with the presence of oxygen, which may reduce the amount of the vitamin in food products, influence thermal resistance, cause degradation and show an antioxidation effect. Vitamin C stimulates the immune cells and collagen synthesis. It may protect the LDL fraction against oxidation, and therefore it is interesting for cosmetology, rheumatology, immunology and dietetics. The latest research with respect to vitamin C proved that it has the ability to dissolve ...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2015; 69:1228-1238 "Novel aspects of human infertility: the role of the male factor"
In the article new aspects of the ‘male factor’ and its role in early stages of pregnancy are described. Among others, genetic and immunogenetic (KIR/KAR, HLA) factors are underlined as well as immunological ones (e.g. microchimerism). A significant part of this review is dedicated to infectious agents and semen inflammation as well as to the TORCH syndrome and chlamydiosis, concentrating on the male part, in which there are a lot of unclarified consequences. The problem of somatic diseases and general homeostasis of the male and its influence on pregnancy with particular emphasis on previous cryptorchidism is also dis...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2015; 69:1222-1227 "Analysis of nanomechanical properties of Borrelia burgdorferi spirochetes under the influence of lytic factors in an in vitro model using atomic force microscopy"
Conclusion: The average value of flexibility of spirochetes’ surface expressed by Young’s modulus was 10185.32 MPa, whereas the adhesion force was 3.68 nN. AFM is a modern tool with a broad spectrum of observational and measurement abilities. Young’s modulus and the adhesion force can be treated as parameters in the evaluation of intensity and changes which take place in pathogenic microorganisms under the influence of various lytic factors. The visualization of the changes in association with nanomechanical features provides a realistic portrayal of the lytic abilities of the elements of the innate and adaptive huma...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2015; 69:1215-1221 "Thrombocytopenia in pregnancy – pathogenesis and diagnostic approach"
Thrombocytopenia (TP) affects 7-10% of pregnant women. It occurs 4 times more frequently in pregnancy than in the non-pregnant women population. Women with thrombocytopenia in pregnancy are a heterogeneous and poorly known group. There are several possible causes of thrombocytopenia in pregnancy. The most common are: gestational thrombocytopenia (GE) (60-75%), preeclampsia (PE) and HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome associated TP (21%), and idiopathic immune thrombocytopenia (ITP) (3-10%). Although thrombocytopenia diagnosed in pregnancy in most cases has a mild course, it has also been repo...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2015; 69:1205-1214 "Angiogenesis and lymphangiogenesis in primary cutaneous T-cell lymphomas"
Primary cutaneous T-cell lymphomas are a group of rare hematologic malignancies, derived from mature T lymphocytes and initially developing only in the skin. The most common lymphomas representing this group are mycosis fungoides and Sezary syndrome. Mycosis fungoides is an indolent disease with a chronic course and characteristic evolution of the skin lesions from erythematous patches, through plaques to tumors. Sezary syndrome is characterized by an aggressive course and a triad of symptoms (erythroderma, generalized lymphadenopathy, and the presence of atypical cells in the skin, lymph nodes and peripheral blood). The e...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2015; 69:1196-1204 "Medical applications of nanotechnology"
Nanotechnologies are new areas of research focusing on affecting matter at the atomic and molecular levels. It is beyond doubt that modern medicine can benefit greatly from it; thus nanomedicine has become one of the main branches of nanotechnological research. Currently it focuses on developing new methods of preventing, diagnosing and treating various diseases. Nanomaterials show very high efficiency in destroying cancer cells and are already undergoing clinical trials. The results are so promising that nanomaterials might become an alternative to traditional cancer therapy, mostly due to the fact that they allow cancer ...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2015; 69:1190-1195 "Saliva of obese patients – is it different?"
Obesity is a major public health concern that increases the risk of cardiovascular disease, type 2 diabetes and cancer. The incidence of obesity has increased significantly in recent years, not only in adults, but also in adolescents and children. This is evidenced by rapidly developing bariatric surgery, the most effective method of treating morbid obesity. Obesity is a multifactorial disease, and its pathogenesis is not completely understood. Numerous studies have been performed to clarify pathogenetic mechanisms, based mostly on blood and sometimes urine samples. Saliva is easily accessible and can be obtained non-invas...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2015; 69:1182-1189 "Pneumococcal and seasonal influenza vaccination among elderly patients with diabetes"
Both seasonal influenza vaccination and pneumococcal vaccination are recommended for elderly diabetics. The aim of the study was to determine the rate of seasonal influenza vaccination over the previous twelve months, pneumococcal vaccination over a lifetime, and to identify predictors which affect likelihood of vaccination. 219 diabetics elders were detailed questioned 3 months after the end of 2012/2013 influenza season. 26.48% of patients have been vaccinated against influenza in the last year and only 9.13% of patients reported pneumococcal vaccination in the past. The logistic regression analysis revealed that varia...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2015; 69:1176-1181 "Bone markers in craniofacial bone deformations and dysplasias"
We present standard (calcium, parathyroid hormone, calcitonin, alkaline phosphatase, vitamin D) and specialized bone markers (pyridinium, deoxypyridinium, hydroxyproline, RANKL/RANK/OPG pathway, growth hormone, insulin-like growth hormone-1) that can be used to evaluate, measure or describe the processes occurring in craniofacial bones. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2015; 69:1169-1175 "The neurotoxicity of pyridinium metabolites of haloperidol"
Haloperydol is a butyrophenone, typical neuroleptic agent characterized as a high antipsychotics effects in the treatment of schizophrenia and in palliative care to alleviation many syndromes, such as naursea, vomiting and delirium. Clinical problems occurs during and after administration of the drug are side effects, particularly extrapyrramidal symptoms (EPS). The neurotoxicity of haloperydol may be initiated by the cationic metabolites of haloperydol, HPP+, RHPP+, formed by oxidation and reduction pathways. These metabolites are transported by human organic cation transporters (hOCT) to several brain structures for exap...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2015; 69:1149-1168 "Heat shock protein HSP60 and the perspective for future using as vaccine antigens"
Heat Shock Proteins (HSPs) are widely spread in nature, highly conserved proteins, found in all prokaryotic and eukaryotic cells. HSPs have been classified in 10 families, one of them is the HSP60 family. HSP60 function in the cytoplasm as ATP-dependent molecular chaperones by assisting the folding of newly synthesised polypeptides and the assembly of multiprotein complexes. There is a large amount of evidence which demonstrate that HSP60 is expressed on the cell surface. Especially in bacteria the expression on the surface occurs constitutively and increases remarkably during host infection. HSP60 also play an important r...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2015; 69:1140-1148 "Dental plaque as a biofilm - a risk in oral cavity and methods to prevent"
Bacteria living constantly in the oral cavity are in the form of a biofilm. The biofilm formed on a solid base such as the enamel of the teeth, fillings, restorations, orthodontic appliances or obturators is dental plaque. Disturbance of homeostasis of biofilm, excessive growth or increase in the number of acid-forming bacteria leads to the development of the most common diseases of the oral cavity, i.e. dental caries and periodontal disease. The presence of bacterial biofilm on the walls of the root canal or at the top of the root on an outer wall leads to complications and failure in endodontic treatment. The aim of the ...
Source: Postepy higieny i medycyny doswiadczalnej - December 22, 2015 Category: Research Tags: Review article Source Type: research