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Postepy Hig Med Dosw 2016; 70:1198-2005 "Anti ‑ cytokine therapy for psoriasis – not only TNF ‑ α blockers. Overview of reports on the effectiveness of therapy with IL ‑ 12/IL ‑ 23 and T and B lymphocyte inhibitors"
TNF ‑ α inhibitors – infliximab, etanercept and adalimumab – can be used in the treatment of psoriasis vulgaris and psoriatic arthritis, along with other inhibitors of proinflammatory cytokines, such as interleukin ‑ 12 (IL ‑ 12) and IL ‑ 23. This paper presents the results of research on the use of biological drugs other than the tumor necrosis factor blockers (TNF ‑ α ), namely inhibitors of IL ‑ 12 and IL ‑ 23 (ustekinumab), T ‑ cell inhibitors (alefacept and efalizumab), B ‑ cell inhibitors (rituximab), anti ‑ IL ‑ 17 agents (secukinumab, ixekizumab, and brodalumab) and IL23p19 inhibitors (...
Source: Postepy higieny i medycyny doswiadczalnej - December 9, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1190-1197 "The matrix metalloproteinase in larynx cancer"
One of the most common carcinoma occurring in the head and neck is laryngeal cancer. Despite the rapid scientific advances in medicine the prognosis for patients with such type of disease is not satisfying. In the last few years matrix metalloproteinases ‑ MMPs and their tissue inhibitors – TIMPs, mostly MMP ‑ 2 and MMP ‑ 9, arouses a great interest, especially in the process of carcinogenesis. It seems that their impact in the formation and development of laryngeal cancer is significant. MMPs a group of zinc ‑ and calcium ‑ dependent endopeptidases play crucial role extracellular matrix collagen degradation. T...
Source: Postepy higieny i medycyny doswiadczalnej - December 9, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1182-1189 "The role of survivin in the diagnosis and therapy of gynaecological cancers"
This article discusses the potential role of survivin in the diagnosis of various types of cancer, as well as selected strategies for the inhibition of both gene expression and protein function. Detailed knowledge of the mechanisms of survivin action may therefore be crucial for effective antitumor therapy development. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - December 9, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1166-1181 "Mechanisms of angiogenesis in neoplasia"
Mechanism of forming new capillary from basal vessels, named angiogenesis, exist under both physiological and pathological conditions. Initiation of this process requires imbalance between proangiogenic and antiangiogenic factors, which can occur for instance under hypoxic conditions. Angiogenesis is complex process which allow tumor cells to proliferate, thus providing tumor to increase its structure. This dependence is highly connected to enhanced migration of tumor cells through blood, which often ends up being an onset of metastasis. It has been proved that capillaries that form during tumor lifetime are different in c...
Source: Postepy higieny i medycyny doswiadczalnej - December 9, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1150-1165 "Endogenous mechanisms of reactive oxygen species (ROS) generation"
The main cellular source of reactive oxygen species (ROS) is mitochondrial respiratory chain and active NADPH responsible for “ respiratory burst ” of phagocytes. Whatsmore ROS are produced in endoplasmic reticulum, peroxisomes, with the participation of xanthine and endothelial oxidase and during autoxidation process of small molecules. Mitochondrial respiratory chain is the main cellular source of ROS. It is considered that in aerobic organisms ROS are mainly formed during normal oxygen metabolism, as byproducts of oxidative phosphorylation, during the synthesis of ATP. The intermembranous phagocyte enzyme – activa...
Source: Postepy higieny i medycyny doswiadczalnej - November 14, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1142-1149 "The role of adipose tissue and excess of fatty acids in the induction of insulin resistance in skeletal muscle"
Skeletal muscle is the main tissue responsible for insulin-stimulated glucose uptake. Consumption of a high-fat diet rich in saturated fats (HFD) and obesity are associated with accumulation of intramuscular lipids that leads to several disorders, e.g. insulin resistance (IRes) and type 2 diabetes (T2D). The mechanism underlying the induction of IRes is still unknown. It was speculated that accumulation of intramuscular triacylglycerols (TAG) is linked to induction of IRes. Now, research focuses on bioactive lipids: long-chain acyl-CoA (LCACoA), diacylglycerols (DAG) and ceramides (Cer). It has been demonstrated that accum...
Source: Postepy higieny i medycyny doswiadczalnej - November 14, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1131-1141 "The importance of selected spices in cardiovascular diseases"
Cardiovascular diseases are the leading cause of death worldwide. Literature data indicate that, due to these diseases, approximately 17.5 million people died in 2012. Types of cardiovascular disease include ischemic heart disease, cerebrovascular disease, peripheral vascular disease, congenital heart disease, rheumatic heart disease, cardiomyopathy and arrhythmia. Proper nutrition is an important factor in reducing the risk of cardiovascular events. An interesting element of our diets is spices. For thousands of years, they have been used in the treatment of many diseases: bacterial infections, coughs, colds, and liver di...
Source: Postepy higieny i medycyny doswiadczalnej - November 14, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1124-1130 "C-reactive protein as a diagnostic and prognostic factor in inflammatory bowel diseases"
Discussion: HsCRP might be a useful diagnostic marker in differentiating active IBD from other diseases. Particularly important however seems to be the predictive value of hsCRP at diagnosis in prognosing the clinical outcome of the disease in CD patients. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - November 7, 2016 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2016; 70:1117-1123 "Prothymosin-alpha and Ki-67 expression in pituitary adenomas"
Conclusions: The positive nuclear expression of Ki-67 and PTMA was observed in the majority of pituitary adenomas. Neither the expression of Ki-67 nor that of PTMA-c was related to tumor recurrence or local invasion. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - November 7, 2016 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2016; 70:1112-1116 "Overuse of proton pump inhibitors and its consequences"
This article summarizes the influence of PPI therapy on gastric mucosa, absorption and occurrence of adverse effects. The authors note that their low awareness among physicians contributes to wide and imprudent use of drugs of this group. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - October 14, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1101-1111 "Photoprotective and radioprotective properties of nitroxides and their application in magnetic resonance imaging"
Nitroxides are a group of stable organic radicals of low molecular weight having a nitroxyl group> N-.O, which has an unpaired electron. The presence of this group allows a nitroxide to participate in redox reactions. They serve as mimics of superoxide dismutase (SOD) and have stimulative properties towards haemoproteins with catalase-like activity. Nitroxides oxidize Fe (II) to Fe (III) preventing the Fenton and Haber-Weiss reactions. As the radicals have the ability to scavenge other free radicals. Nitroxides are not immunogenic, and mutagenic and do not show toxicity to the human cells. The review discusses the use ...
Source: Postepy higieny i medycyny doswiadczalnej - October 14, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1095-1100 "Impact of lymphocyte culture media on the number of metaphases and chromosome band resolution"
A special type of differential staining of chromosomes is replication banding. This staining technique reveals the band pattern characteristic of each homologous pair of chromosomes, which is a reflection of heterogeneous euchromatin structure. Banding enables identification of homologous chromosomes and detection of chromosomal aberrations, both structural and numerical. Slide preparation requires knowledge of many techniques, and the procedure is often different for each laboratory. The aim of the study was to determine the effect of selected media for lymphocyte cultures on the number of metaphases and the band resoluti...
Source: Postepy higieny i medycyny doswiadczalnej - October 11, 2016 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2016; 70:1087-1094 "Paxillin and its role in the aging process of skin cells"
Morphology of senescent cells is constantly changing at the molecular level, which in turn leads to disruption of their function. It is connected with reduced ability to synthesize extracellular matrix (ECM) and leads to the dysfunction of integrin adhesion molecules and adhesion clusters. In skin, these factors cause a loss of communication between the extracellular matrix and fibroblasts. This contributes to the appearance of signs of aging. The aim of this study is to draw attention to the very important molecule such as paxillin, which is an adaptor protein with mass of 68 kDa. This family of proteins includes Hic-5, P...
Source: Postepy higieny i medycyny doswiadczalnej - October 6, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1068-1086 "Can mutations in the gene encoding transcription factor EKLF (Erythroid Kr ü ppel-Like Factor) protect us against infectious and parasitic diseases?"
Transcription factor EKLF (Erythroid Kr ü ppel-Like Factor) belongs to the group of Kr ü ppellike factors, which regulate proliferation, differentiation, development and apoptosis of mammalian cells. EKLF factor is present in erythroid cells, where it participates in regulation of hematopoiesis, expression of genes encoding transmembrane proteins (including blood group antigens), and heme biosynthesis enzymes. It is also a key factor in downregulation of γ -globins and activation of β -globin gene expression. The EKLF factor consists of two domains: proline-rich transactivation domain and DNA-binding domain containing ...
Source: Postepy higieny i medycyny doswiadczalnej - October 6, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1059-1067 "Immunoregulatory action of melatonin. The mechanism of action and the effect on inflammatory cells"
Literature data indicate a significant immunoregulatory role of melatonin. Melatonin exerts an effect directly affecting leucocytes bearing specific melatonin receptors or indirectly by means of melatonin regulating other hormones, opioids or cytokines. Despite numerous experiments, the influence of the hormone on the immune system is still controversial. Melatonin affects the immune response acting as both an activator and an inhibitor of the inflammatory process. The hormone acts as an “ immunological buffer ” activating impaired immunity in immunosuppression, chronic stress or old age as well as suppressing overreac...
Source: Postepy higieny i medycyny doswiadczalnej - October 4, 2016 Category: Research Tags: Review article Source Type: research