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Postepy Hig Med Dosw 2017; 71:32-39 "Visual evoked potentials in diagnostics of optic neuropathy associated with renal failure"
Chronic renal failure is associated with many neurological complications. Due to accumulation of uremic neurotoxins axonal degeneration with its secondary demyelination occurs, which results in development of polineuropathy in 60 ‑ 100% of patients with chronic renal failure. One of the most severe peripheral neuropathy is optic neuropathy. It is associated with visual deterioration and reduction in quality of life. Symptoms of the optic neuropathy may appear either before or after dialysis therapy. They often worsen after renal transplant, probably due to immunosuppressive regimen. Early diagnostics of the optic neuropa...
Source: Postepy higieny i medycyny doswiadczalnej - January 22, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:20-31 "Effects of endogenous cardioprotective mechanisms on ischemia-reperfusion injury"
Ischemic heart disease have been remarked as a leading cause of morbidity and mortality in adults. Early restoration of cardiac perfusion is necessary to restore perfusion of ischemic heart muscle. Effective revascularization reduce mortality by limiting myocardial necrosis at the acute phase of the cardiac infarction. However, reperfusion may induce a cascade of pathophysiological reactions causing the increase of the infarct area of the myocardium This phenomenon known as ischemia-reperfusion injury is responsible for up to 50% of the final infarct size. Sequences of brief episodes of nonlethal ischemia and reperfusion a...
Source: Postepy higieny i medycyny doswiadczalnej - January 22, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:5-19 "The role of interleukin 15 in neoplasia"
Interleukin 15 is a pleiotropic cytokine of the four α helix bundle family. Binding to a heterotrimeric receptor complex, which consists of a unique, high affinity IL ‑ 15R α ‑ chain and IL-2/IL-15R β and IL ‑ 2R γ chains, IL ‑ 15 activates signaling pathways leading to activation and proliferation of T and B cells, as well as natural killer cells. At the same time, IL ‑ 15 protects effector cells from T regulatory cells and does not induce immune tolerance. The significant regulatory action of IL ‑ 15 on the immune system provides new opportunities for development of anti ‑ cancer therapies. As document...
Source: Postepy higieny i medycyny doswiadczalnej - January 22, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:1-4 "Activity of urine arylsulfatase A in brain ‑ dead graft donors is a predictor of early and late graft function"
Conclusions: The results of this study suggest that arylsulfatase A has a protective effect on kidney allograft, and the urine activity of this enzyme in kidney donors correlates positively with graft function. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - January 22, 2017 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2016; 70:1483-1498 "Trace elements as an activator of antioxidant enzymes"
Oxidative stress is a state of impaired balance between the formation of free radicals and antioxidant capacity of the body. It causes many defects of the body, e.g. lipid peroxidation, DNA and protein damage. In order to prevent the effects of oxidative stress, the organism has developed defence mechanisms. These mechanisms capture and inhibit the formation of free radicals and also chelate ion metals that catalyse free radical reactions. Trace elements are components of antioxidant enzymes involved in antioxidant mechanisms. Selenium, as a selenocysteine, is a component of the active site of glutathione peroxidase (GPx)....
Source: Postepy higieny i medycyny doswiadczalnej - January 18, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1469-1482 "The role of cancer stem cells in pathogenesis of colorectal cancer"
We present evidence for the importance of the interactions between CSCs and their environment in the propagation of the disease. It is hoped that further studies of colorectal cancer CSCs could be helpful in the early detection and improved therapy of this neoplasm. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - January 5, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1460-1468 "Antioxidant and antimicrobial properties of bioactive phytochemicals from cranberry"
In the rational human diet, the important role of fruits and vegetables, which are a source of bioactive phytochemicals, is emphasized. Among fruits particular attention, due to a number of documented health-promoting properties, is focused on cranberry. This fruit is characterized by the high content of antioxidant phenolic compounds, which may support the natural antioxidant defense system of the body in the prevention of damage caused by oxidative stress induced by reactive oxygen species (ROS). Therefore, cranberry is suggested for the prevention of civilization diseases such as atherosclerosis, hypertension and cancer...
Source: Postepy higieny i medycyny doswiadczalnej - January 5, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1451-1459 "Allergenicity of milk of different animal species in relation to human milk"
Protein content in cow milk (with over 20 proteins, and peptides may also occur as a result of enzymatic hydrolysis) ranges from 2.5% to 4.2% and is about 1.5-2 times higher than in human milk. Its most important allergens are considered to be β -lactoglobulin (absent in human milk) and α s1-casein. The most similar in composition to human milk is horse and donkey milk. It contains considerably more whey proteins (35-50%) than cow milk (about 20%), and the concentration of the most allergenic casein fraction α s1 is 1.5-2.5 g/l. In comparison, the content of α s1-casein in cow milk is about 10 g/l. β -lactoglobulin pr...
Source: Postepy higieny i medycyny doswiadczalnej - January 4, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1441-1450 "Effects of Propofol on Oxidative Stress Parameters in Selected Parts of the Brain in a Rat Model of Parkinson Disease"
Conclusions: A shortage of natural antioxidants is observed in PD, along with an increase in pro-oxidants in many brain areas. Propofol inhibits oxidative stress in the brain, which shows its neuroprotective properties against oxidative damage. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - January 4, 2017 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2016; 70:1424-1440 "Molecular characteristic and physiological role of DOPA-decarboxylase"
The enzyme DOPA decarboxylase (aromatic-L-amino-acid decarboxylase, DDC) plays an important role in the dopaminergic system and participates in the uptake and decarboxylation of amine precursors in the peripheral tissues. Apart from catecholamines, DDC catalyses the biosynthesis of serotonin and trace amines. It has been shown that the DDC amino acid sequence is highly evolutionarily conserved across many species. The activity of holoenzyme is regulated by stimulation/blockade of membrane receptors, phosphorylation of serine residues, and DDC interaction with regulatory proteins. A single gene codes for DDC both in neurona...
Source: Postepy higieny i medycyny doswiadczalnej - January 3, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1409-1423 "The role genes encoding of killer cell immunoglobulin-like receptors (KIRs) and their ligands in susceptibility to and progression of HIV infection"
NK cells are a part of the innate antiviral response. Their activity is regulated by signals from the surface receptors. Some of them, known as killer cell immunoglobulin-like receptors (KIRs), determine the quality and intensity of the immunological response, together with their ligands (HLA class I). KIR genes are very polymorphic, and this is reflected in the NK activity modulation. The stimulation of NK cells, especially in the early stages of the infection, can reduce the transmission of HIV or slow down the progression of infection. The varied KIR/HLA repertoire is a limiting factor for the risk of HIV infection and ...
Source: Postepy higieny i medycyny doswiadczalnej - January 3, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1404-1408 "Influence of 28-O-propynoylbetulin on proliferation and apoptosis of melanotic and amelanotic human melanoma cells"
Discussion: The study revealed that 28-O-propynoylbetulin may have diverse effects on melanoma cells and could be a strong inhibitor of cell growth (C32 cells) or exert a more potent proapoptotic effect (A2058 cells). These findings support the possibility of the use of EB5 in different antimelanoma approaches. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - January 3, 2017 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2016; 70:1389-1403 "Genetic background of aberrant thermogenin expression (UCP1) in obesity leading to metabolic syndrome"
Cardiovascular and metabolic disturbances individually and interdependently lead to chronic pathological conditions observed in cardio-metabolic diseases (CMDs). In Europe, the morbidity and mortality caused by cardiovascular disease are the highest among all diseases. Therefore, it seems important to search for new and alternative therapies for obesity, which is the main cause of type 2 diabetes (T2D) and cardiovascular disease (CD). Great attention has been paid to the role of brown adipose tissue in fat burning and the possibility of transformation of the white adipose tissue to cells with brown adipose tissue function ...
Source: Postepy higieny i medycyny doswiadczalnej - January 3, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1378-1388 "Regulatory lymphocytes in thyroid orbitopathy and autoimmune thyroid diseases"
Thyroid orbitopathy (OT), as an organ ‑ specific autoimmune disease, is a result of immune dysregulation leading to loss of control over inflammation directed against self ‑ antigens. The source of the autoreactive lymphocytes is the impairment of central tolerance as well as their induction on the periphery by modified or sequestered by that time antigens. Active suppression by the various subpopulations of regulatory lymphocytes (Lreg) acts as a counterbalance to the proinflammatory factors and is aimed at dampening pathological reaction. Thereby, qualitative or quantitative shortfalls of Lreg play a critical role in...
Source: Postepy higieny i medycyny doswiadczalnej - January 2, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1367-1377 "Role of prometastatic factors in gastric cancer development"
The second half of the 20th century has seen a sharp worldwide decline in both the incidence and mortality of gastric cancer. Despite this, gastric cancer is the most common cause of mortality in the world. It is closely related to the commonly asymptomatic course at the beginning and delayed diagnosis. Approximately 90 ‑ 97% of stomach cancers are adenocarcinomas, which may be subdivided histologically into two categories – intestinal type, and diffuse type. Cancer metastasis is a complex multi ‑ step process that is closely associated with tumor phenotype. The most important steps in the metastasis process are prot...
Source: Postepy higieny i medycyny doswiadczalnej - January 2, 2017 Category: Research Tags: Review article Source Type: research