Postepy higieny i medycyny doswiadczalnej This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Postepy Hig Med Dosw 2016; 70:1044-1058 "PD1/PD1L pathway, HLA-G and T regulatory cells as new markers of immunosuppression in cancers"
The appropriate function of the immune system depends on the effective regulation of the immune response on multiple levels. The key element of an effective immune response to antigenic stimulation is maintaining a homeostasis between activation and inhibitory function of immunocompetent cells and molecules. In pathological conditions such as chronic infections, autoimmune diseases or cancer there are significant alterations, and prevalence of signals of one type over another. Main markers of these dysfunctions are altered expressions of molecules, such as programmed death-1 (PD-1), Human Leukocyte Antigen G (HLA-G), or ch...
Source: Postepy higieny i medycyny doswiadczalnej - October 4, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1032-1043 "Vaccines in prophylaxis of urinary tract infections caused by the bacteria from the genus Proteus"
Urinary tract infections (UTIs) pose a threat especially to women, the individuals with weakened immunity or with abnormalities in the urinary tract as well as to hospitalized and catheterized patients. The bacteria from the genus Proteus, especially P. mirabilis, are important UTI pathogenic factors. They frequently cause chronic, recurrent or severely complicated infections, resulting in the urinary stones production due to urease and other virulence factors. The ability to survive inside the stones and the increasing antibiotic resistance make it difficult to eradicate the bacteria from the urinary tract. A good solutio...
Source: Postepy higieny i medycyny doswiadczalnej - September 30, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1026-1031 "Role of oncogene 24p3 neutrophil gelatinase-associated lipocalin (NGAL) in digestive system cancers"
Neutrophil gelatinase-associated lipocalin, known also as 24p3 lipocalin, lipocalin-2 or uterocalin (in mouse), is a small secretory protein binding small molecular weight ligands which takes part in numerous processes including apoptosis induction in leukocytes, iron transport, smell, and prostaglandins and retinol transport [19]. It was discovered in activated neutrophils as a covalent peptide associated with human gelatinase neutrophils [7]. Neutrophil lipocalin is secreted physiologically in the digestive system, respiratory tract, renal tubular cells, liver or immunity system. Systematic (circulated in plasma) neutrop...
Source: Postepy higieny i medycyny doswiadczalnej - September 28, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1017-1025 "Short-term exposure to ambient fine particulate matter (PM2,5 and PM10) and the risk of heart rhythm abnormalities and stroke"
Results of epidemiological studies suggest a significant impact of ambient particulate matter air pollution (PM10 and PM2,5) on the health of the population. Increased level of these pollutants is connected with increased rate of daily mortality and hospitalizations due to cardiovascular diseases. Among analyzed health effects, heart arrhythmias and stroke are mentioned most frequently. The aim of the study was to present the current knowledge of potential influence of the exposure to fine particulate matter on the presence of arrhythmias and strokes. Subject literature review suggests, that there is a link between short-t...
Source: Postepy higieny i medycyny doswiadczalnej - September 28, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1005-1016 "The classification, structure and functioning of Ago proteins in Eukaryotes"
Ago proteins are members of the highly specialized and conserved Argonaute family, primarily responsible for regulation of gene expression. As a part of RNA-induced silencing complexes (RISCs) Ago proteins are responsible for binding a short RNA and cleavage/inhibition of translation of target mRNAs. Phosphorylation may work as the switch between those two functions, but the role of magnesium ion concentration is also taken into consideration. Recent reports indicate that Ago proteins can interact with an mRNA and cause inhibition of translation without the participation of a short RNA. As key elements in RNA interference ...
Source: Postepy higieny i medycyny doswiadczalnej - September 28, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:1001-1004 "Evidence for the efficacy of immunotherapy in children with high-risk neuroblastoma"
Neuroblastoma is the most common extra-cranial malignancy of childhood, with the highest incidence in children younger than 4 years. The prognosis depends on many factors, such as age at diagnosis, stage of disease and molecular genetic subtype. More than 50% of children who present with the disease are deemed to have high-risk neuroblastoma. The standard therapy for children with high-risk neuroblastoma consists of intensive chemotherapy, surgery, radiotherapy, myeloablative consolidation with autologous haematopoietic stem cell rescue followed by the treatment of minimal residual disease with 13-cis-retinoic acid. Unfort...
Source: Postepy higieny i medycyny doswiadczalnej - September 28, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:989-1000 "Bacteriophages to combat foodborne infections caused by food contamination by bacteria of the Campylobacter genus"
It is estimated that each year more than 2 million people suffer from diarrheal diseases, resulting from the consumption of contaminated meat. Foodborne infections are most frequently caused by small Gram-negative rods Campylobacter. The hosts of these bacteria are mainly birds wherein they are part of the normal intestinal flora. During the commercial slaughter, there is a likelihood of contamination of carcasses by the bacteria found in the intestinal content. In Europe, up to 90% of poultry flocks can be a reservoir of the pathogen. According to the European Food Safety Authority report from 2015, the number of reported...
Source: Postepy higieny i medycyny doswiadczalnej - September 26, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:981-988 "Adropin – physiological and pathophysiological role"
This article provides an overview of the existing literature about the role of adropin, both in physiological and pathophysiological conditions. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - September 26, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:968-980 "Expression and activity of SNAIL transcription factor during Epithelial to Mesenchymal Transition (EMT) in cancer progression"
Inhibition of E-cadherin gene expression by transcription factor SNAIL is known to be a crucial element of Epithelial to Mesenchymal Transition; EMT. Epigenetic regulation of E-cadherin expression is regulated by SNAIL binding to E-box sequences in the CDH1 gene promoter and recruiting enzymes belonging to repressor complexes that are directly engaged in histone modifications and DNA methylation leading to the modification of chromatin structure. SNAIL involvement in cell acquisition of invasive phenotype is based on direct suppression of tight-junction and gap junction proteins. The nuclear localization of SNAIL is requi...
Source: Postepy higieny i medycyny doswiadczalnej - September 19, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:959-967 "Assessment of the influence of peripheral blood mononuclear cell stimulation with Streptococcus pneumoniae polysaccharides on expression of selected Toll-like receptors, activation markers and Fas antigen in patients with chronic lymphocytic leukemia"
Conclusions: We found that both T and B cells respond to antigens of PPV23 by inducing TLR-dependent pathways, lymphocyte activation and CD95 expression. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - September 19, 2016 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2016; 70:951-958 "Rola zewn ą trzkom ó rkowych p ę cherzyk ó w b ł onowych w interakcji paso ż yt- ż ywiciel"
Zewn ą trzkom ó rkowe p ę cherzyki b ł onowe (EVs, extracellular vesicles), pocz ą tkowo uwa ż ane za elementy zniszczonych kom ó rek, okaza ł y si ę niezwykle istotnym sposobem przekazywania informacji mi ę dzy kom ó rkami, bez ich bezpo ś redniego kontaktu. Ze wzgl ę du na powszechne wyst ę powanie EVs w kom ó rkach organizm ó w zar ó wno jedno-, jak i wielokom ó rkowych nale ż ą cych do r ó ż nych grup systematycznych oraz ze wzgl ę du na pe ł nion ą rol ę w komunikacji mi ę dzykom ó rkowej sta ł y si ę przedmiotem licznych bada ń i dyskusji. EVs s ą uwalniane przez kom ó rki prokariotyc...
Source: Postepy higieny i medycyny doswiadczalnej - September 14, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:938-950 "The role of 6-phosphofructo-2-kinase (PFK-2)/fructose 2,6-bisphosphatase (FBPase-2) in metabolic reprogramming of cancer cells"
The objective of this review is to highlight the recent studies on aberrant expression of PFKFBs and its influence on cancer progression. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - September 14, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:928-937 "Growth hormone deficiency in children and young adults"
Growth hormone (GH) is a naturally occurring polypeptide hormone produced by somatotropic cells in the anterior pituitary. The main function of somatotropin is stimulation of linear growth, but it also affects carbohydrate metabolism, increases bone mass and has potent lipolytic, antinatriuretic and antidiuretic effects. Growth hormone deficiency (GHD) may occur both in children and in adults. At the moment there is no gold standard for the diagnosis of GHD, and the diagnosis should take into account clinical, auxological, biochemical and radiological changes and, if necessary, genetic testing. Recent studies have highligh...
Source: Postepy higieny i medycyny doswiadczalnej - September 13, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:917-927 "The renin-angiotensin-aldosterone system (RAAS) – physiology and molecular mechanisms of functioning"
Secretion of renin juxtaglomerular cells into bloodstream initiates activation of an enzymatic-hormonal cascade known as the RAAS (renin – angiotensin – aldosterone system). As a result, blood pressure is increased by the means several interrelated mechanisms. Mechanism of Zjednoczoaction of this system has been known for decades, but a few previously unknown components were recently added, such as ACE-2 and Ang(1-7), and their role often seems to be opposite to that of the conventional components. Local tissue systems also have important biological functions. They operate largely independently of the systemic activity...
Source: Postepy higieny i medycyny doswiadczalnej - September 13, 2016 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2016; 70:901-916 "The CRISPR-Cas system – from bacterial immunity to genome engineering"
Precise and efficient genome modifications present a great value in attempts to comprehend the roles of particular genes and other genetic elements in biological processes as well as in various pathologies. In recent years novel methods of genome modification known as genome editing, which utilize so called “ programmable ” nucleases, came into use. A true revolution in genome editing has been brought about by the introduction of the CRISP-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated) system, in which one of such nucleases, i.e. Cas9, plays a major role. This system is based on the e...
Source: Postepy higieny i medycyny doswiadczalnej - September 1, 2016 Category: Research Tags: Review article Source Type: research