Postepy higieny i medycyny doswiadczalnej 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Postepy Hig Med Dosw 2016; 70:169-179 "Pancreatic cancer- mechanisms of chemoresistance"
Despite the enormous progress made over the past decades in diagnosis, treatment and prevention of many types of tumor, the survival rate for pancreatic cancer still remains poor. Pancreatic cancer is one of the most malignant and chemotherapy-resistant tumors. That is mainly due to the lack of effective diagnosis at an early stage of tumor development and ineffective therapy. In most patients the disease is diagnosed at an advanced, metastatic stage and only 15-20% of patients are eligible for surgical removal of the tumor, which still remains the only chance for radical treatment. Studies in recent years have not yielded...
Source: Postepy higieny i medycyny doswiadczalnej - March 5, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:162-168 "Depression and inflammation in rheumatic diseases"
It is known that the prevalence of depression in rheumatologic patients is higher than in the general population. Socioeconomic factors are not a sufficient explanation of mood disorder in these patients. Symptoms reported by patients with chronic inflammatory diseases resemble changes defined as “sickness behavior”. Mood disorders among somatic patients could be explained by disturbances of the immune system according to the monoaminergic theory of depression. Inflammatory factors such as IL-1 (interleukin-1), IL-2 (interleukin-2), IL-6 (interleukin-6), TNF-α (tumor necrosis factor α), and IFN-γ (interferon-γ) act...
Source: Postepy higieny i medycyny doswiadczalnej - March 5, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:143-161 "Duffy blood group antigens: structure, serological properties and function"
Duffy (Fy) blood group antigens are located on seven-transmembrane glycoprotein expressed on erythrocytes and endothelial cells, which acts as atypical chemokine receptor (ACKR1) and malarial receptor. The biological role of the Duffy glycoprotein has not been explained yet. It is suggested that Duffy protein modulate the intensity of the inflammatory response. The Duffy blood group system consists of two major antigens, Fya and Fyb, encoded by two codominant alleles designated FY*A and FY*B which differ by a single nucleotide polymorphism (SNP) at position 125G>A of the FY gene that results in Gly42Asp amino acid chang...
Source: Postepy higieny i medycyny doswiadczalnej - March 5, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:135-142 "Metabolism of glycosaminoglycans in the course of juvenile idiopathic arthritis"
Juvenile idiopathic arthritis (JIA) is a non-homogeneous autoimmune children’s disease which, despite the applied therapy, has a progressive character with recurrences, leading to damage of joint structures. Progressive wearing of the joint cartilage in the course of JIA, which results from the imbalance between the biological strength of the cartilage, its function and exerted pressure forces, is linked to metabolic disorders of extracellular matrix (ECM) components. Among the latter compounds, the proteoglycan (PG) aggrecan plays a particular role in maintaining the mechanical-immunological properties of the cartilage....
Source: Postepy higieny i medycyny doswiadczalnej - March 5, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:124-134 "Systemic contact dermatitis"
Systemic contact dermatitis (SCD) is a skin inflammation occurring in a patient after systemic administration of a hapten, which previously caused an allergic contact skin reaction in the same person. Most frequently, hypersensitivity reactions typical for SCD occur after absorption of haptens with food or inhalation. Haptens occur mainly in the forms of metals and compounds present in natural resins, preservatives, food thickeners, flavorings and medicines. For many years, several studies have been conducted on understanding the pathogenesis of SCD in which both delayed type hypersensitivity (type IV) and immediate type I...
Source: Postepy higieny i medycyny doswiadczalnej - February 27, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:117-123 "The role of resveratrol in the regulation of cell metabolism – a review"
Moderate wine drinking is associated with reduced risk of cardiovascular, cerebrovascular and peripheral vascular disease, and reduced risk of cancer. This phenomenon is called the “French paradox”, since it was observed for the first time in France – a country famous for its wine production. In the literature, the cardioprotective effect of wine is very well described and attributed mainly to contained therein resveratrol. Recently, it has been demonstrated that resveratrol extends the lifespan of yeast through activation of the SirT1 longevity gene, which is also responsible for the longevity caused by caloric rest...
Source: Postepy higieny i medycyny doswiadczalnej - February 27, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:1124-1134 "Systemic contact dermatitis"
Systemic contact dermatitis (SCD) is a skin inflammation occurring in a patient after systemic administration of a hapten, which previously caused an allergic contact skin reaction in the same person. Most frequently, hypersensitivity reactions typical for SCD occur after absorption of haptens with food or inhalation. Haptens occur mainly in the forms of metals and compounds present in natural resins, preservatives, food thickeners, flavorings and medicines. For many years, several studies have been conducted on understanding the pathogenesis of SCD in which both delayed type hypersensitivity (type IV) and immediate type I...
Source: Postepy higieny i medycyny doswiadczalnej - February 25, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:117-1123 "The role of resveratrol in the regulation of cell metabolism – a review"
Moderate wine drinking is associated with reduced risk of cardiovascular, cerebrovascular and peripheral vascular disease, and reduced risk of cancer. This phenomenon is called the “French paradox”, since it was observed for the first time in France – a country famous for its wine production. In the literature, the cardioprotective effect of wine is very well described and attributed mainly to contained therein resveratrol. Recently, it has been demonstrated that resveratrol extends the lifespan of yeast through activation of the SirT1 longevity gene, which is also responsible for the longevity caused by caloric rest...
Source: Postepy higieny i medycyny doswiadczalnej - February 25, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:110-116 "Evaluation of potential prognostic value of Bmi-1 gene product and selected markers of proliferation (Ki-67) and apoptosis (p53) in the neuroblastoma group of tumors"
Conclusions: Bmi-1 seems to be a promising marker in the neuroblastoma group of tumors whose expression correlates with widely accepted prognostic parameters. The pattern of BMI-1 expression may indicate that the examined protein is also involved in maturation processes in tumor tissue. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - February 25, 2016 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2016; 70:104-109 "Dietary fibre as an important constituent of the diet"
The intake of fibre in the diet of a child or an adult, through various foods (such as wholegrain foods, nuts, fruits and vegetables), plays an important role in reducing the risk and lowering the incidence of numerous diseases. The interest of researchers and consumers in the role of diet in the prevention or treatment of many illnesses, and maintaining the general and oral health, has been growing lately. The aim of our study was to underline the role of dietary fibre through its effects on many aspects of the human body and metabolism. Evidence has been found that dietary fibre from whole foods or supplements may reduce...
Source: Postepy higieny i medycyny doswiadczalnej - February 25, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:95-103 "Galectins in hematological malignancies – role, functions and potential therapeutic targets"
Galectins are a family of lectins characterized by an affinity for β – galactosides through the carbohydrate recognition domain (CRD). The extracellular and intracellular presence of Galectins has been described. Their activity and functions are mainly attributed to cell type. The tumor microenviroment is a complex milieu connected with immunosupression, angiogenesis and hypoxic compartments. The studies of interactions between Glycans – Lectins are highly advanced and promising. We are not able to explain the pathogenesis of many diseases only by protein – protein interactions, that is why in these studies is a cha...
Source: Postepy higieny i medycyny doswiadczalnej - February 15, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:86-94 "Carcinogenic viruses in etiopathogenesis of skin cancers in patients after organ transplantation"
The latest literature report specifies multifactoral etiology of skin cancer in population of patients after organs transplats. Carcirogenic viruses are one of etiopathogenesis components. Viruses of a vital meaning for skin oncogenesis are called Human papillomavirus – HPV, Human herpesvirus 8 – HHV8 i Merkel cell polyomavirus – MCV. Report on connections exisisting between viruses HPV and skin cancers in the population of patients after organs transplants confirms clinical connection between viruses papillas and cancers centres occuring in similar locations and more frequent appearance of attributes characteristic ...
Source: Postepy higieny i medycyny doswiadczalnej - February 15, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:80-85 "786T/c endothelial nitric oxide synthase gene polymorphism and coronary collateral circulation"
In this study, we investigated the association between -786T/C polymorphism of the endothelial nitric oxide (NOS3) gene in which thymidine is replaced by a cytosine at nucleotide -786 (rs 2070744) and coronary collateral circulation (CCC) in patients with stable coronary artery disease.
Materials and Methods: 286 patients having a critical stenosis (> 95%) in at least one major epicardial coronary vessel were included in the study. CCC was defined according to the Rentrop classification (R). Patients with R0-1 CCC were included in the poor CCC group and subjects with R2-3 CCC were assigned to the good CCC group. The p...
Source: Postepy higieny i medycyny doswiadczalnej - February 13, 2016 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2016; 70:74-79 "Effect of methylprednisolone, hyaluronic acid and pioglitazone on histological remodeling of
temporomandibular joint cartilage in rabbits affected by drug-induced osteoarthritis"
Conclusion: Pioglitazone and hyaluronic acid showed anti-degenerative properties compared to methylprednisolone in an animal model. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - February 13, 2016 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2016; 70:67-73 "Znaczenie białek z rodziny ADAM w nowotworach złośliwych"
W ostatnich latach pojawia się coraz więcej doniesień o roli adamalizyn (ADAM) w nowotworach złośliwych. Dotąd opisano ponad 30 przedstawicieli tej grupy, z czego prawie 20 występuje u człowieka. Białka z rodziny ADAM tworzą jednorodną pod względem strukturalnym grupę białek, które regulują w organizmie człowieka wiele procesów, począwszy od stadium embriogenezy aż po migrację komórkową, adhezję, fuzję komórek. Połowa z nich ma aktywność proteolityczną i bierze udział w degradacji macierzy międzykomórkowej oraz rozpadzie niektórych kompleksów białkowych, regulując tym samym biodostępno...
Source: Postepy higieny i medycyny doswiadczalnej - February 13, 2016 Category: Research Tags: Review article Source Type: research
