Postepy higieny i medycyny doswiadczalnej 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Postepy Hig Med Dosw 2016; 70:305-312 "Markery zapalenia, aktywacja płytek krwi i zaburzenia krzepnięcia w chorobach zapalnych jelit"
Inflammatory bowel disease (IBD) includes ulcerative colitis and Crohn’s disease. It is a group of chronic disorders characterized by inflammation of the gastrointestinal track with unknown etiology. Currently applied biomarkers include CRP, ESR, pANCA, ASCA, and fecal calprotectin. The etiopathogenesis of IBD is multifactorial. In patients with IBD in inflamed alimentary tract mucosa the number of recruited monocytes and activated macrophages which are source of cytokines. In IBD, the exacerbation is accompanied by thrombocytosis. Platelets play a crucial role in the hemostasis and inflammatory response. Selectins, whic...
Source: Postepy higieny i medycyny doswiadczalnej - April 13, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:295-304 "Explaining the Decrease in Deaths from Cardiovascular Disease in Poland. The Top-Down Risk Assessment Approach, from Policy to Health Impact"
Conclusions: The significant mortality decrease can indicate to policy makers that it is necessary to prioritize policies to manage effective, innovative medical interventions. Topdown policy risk assessment is a useful methodological tool to present the full chain of interactions. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - April 13, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:280-294 "PARP1 inhibitors: contemporary attempts at their use in anticancer therapy and future perspective"
Current cancer therapies are based mainly on the use of compounds that cause DNA damage. Unfortunately, even the combination therapies do not give rewarding effects, due to the high efficiency of DNA damage repair mechanisms in tumor cells. Therefore, the present studies should be focused on proteins that are involved in DNA repair systems. Poly(ADP-ribose) polymerase-1 is an example of a protein commonly known as an enzyme that plays a role in the detection of DNA damage and repair. Activation of PARP1 in response to DNA damage leads to poly-ADP-ribosylation of proteins contributing to DNA repair systems, therefore facili...
Source: Postepy higieny i medycyny doswiadczalnej - April 13, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:272-279 "Evaluation of serum chemokine RANTES concentration as a biomarker in the diagnosis of early-onset severe infections in neonates"
Conclusion. The significant increase of serum RANTES concentration in early-onset infections in neonates, regardless of their gestational age, sex and birth asphyxia, not only proves the presence of an active immunological process but also may be a useful biomarker for diagnosis of severe neonatal infections. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - April 6, 2016 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2016; 70:265-271 "DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin"
Inflammatory bowel diseases (IBD) are chronic, relapsing, inflammatory disorders of the gastrointestinal tract, and continuing colonic inflammation is considered an important risk factor in the development of colorectal cancer. Our previous studies showed that beetroot (Beta vulgaris var. rubra) products and their major component betanin modulate the reactive oxygen species (ROS) production and DNA damage in 12-O-tetradecanoylphorbol 13-acetate (TPA) stimulated human polymorphonuclear neutrophils of healthy volunteers. The aim of the present study was to evaluate the effects of betanin on the oxidative DNA damage and apopt...
Source: Postepy higieny i medycyny doswiadczalnej - April 6, 2016 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2016; 70:258-264 "EGFR and Bcl-2 in gastric mucosa of children infected with Helicobacter pylori"
Conclusion: Increased expression of EGFR and Bcl-2 proteins in the epithelial cells and a statistically significant positive correlation between the numbers of cells expressing EGFR and Bcl-2 in H. pylori infected children could suggest increased regeneration abilities of gastric mucosa. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - March 25, 2016 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2016; 70:251-257 "Immunological markers of rheumatoid arthritis"
Rheumatoid arthritis (RA) is the most common connective tissue disease of autoimmune origin. The disease is characterized by chronic inflammation leading to bone erosions and organ involvement. RA is a progressive disease. It affects the quality of life, leading to disability and death mainly due to premature cardiovascular disease. Early diagnosis and appropriate treatment are essential for prognosis and quality of life improvement.
In 2010 the American College of Rheumatology (ACR) and The European League Against Rheumatism (EULAR) established new RA classification criteria. Besides clinical symptoms it includes two imm...
Source: Postepy higieny i medycyny doswiadczalnej - March 25, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:243-250 "The role of endogenous cardiotonic steroids in pathogenesis of cardiovascular and renal complications of arterial hypertension"
Endogenous cardiotonic steroids (CTS), also called digitalis-like factors, are a group of steroid hormones linking high salt intake and elevated blood pressure and in part responsible for target organ damage in arterial hypertension. CTS act primarily through their ability to inhibit the ubiquitous transport enzyme sodium-potassium adenosine triphosphatase (Na+/K+-ATPase). A portion of Na+/K+-ATPase does not seem to actively “pump” sodium and potassium but is closely associated with other key signaling proteins. Plasma concentration and urine excretion of CTS are increased in experimental models with volume expansion a...
Source: Postepy higieny i medycyny doswiadczalnej - March 19, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:231-242 "Molecular bases of cellular senescence: Hayflick phenomenon 50 years later"
Normal human somatic cells have strictly limited proliferative capacity and reach a state of senescence when it becomes exhausted. It is believed that senescence is a response to extensive and irreparable DNA injury, localized in telomeric and/or non-telomeric regions of the genome. Main cause of this damage is oxidative stress, increasing due to deteriorated function of mitochondria. Senescent cells accumulate in tissues during aging, which is causatively linked with the development of various pathologies in elderly individuals, including cancer. This paper, prepared exactly 50 years after Leonard Hayflick’s discovery o...
Source: Postepy higieny i medycyny doswiadczalnej - March 19, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:219-230 "Aminotransferaza asparaginianowa – kluczowy enzym w metabolizmie ogólnoustrojowym człowieka"
Aspartate aminotransferase is an organ - nonspecific enzyme located in many tissues of the human body where it catalyzes reversible reaction of transamination. There are two aspartate aminotransferase isoforms - cytoplasmic (AST1) and mitochondrial (AST2), that usually occur together and interact with each other metabolically. Both isoforms are homodimers containing highly conservative regions responsible for catalytic properties of enzyme. The common feature of all aspartate aminotransfeses is Lys – 259 residue covalent binding with prosthetic group - pyridoxal phosphate. The differences in the primary structure of AST ...
Source: Postepy higieny i medycyny doswiadczalnej - March 17, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:210-218 "Wegener’s granulomatosis and pyoderma gangrenosum – rare causes of facial ulcerations"
This study revealed a similar rate of comorbidity of WG and PG in both genders and an increased incidence of both diseases after the age of 50. Among skin lesions there was a dominance of ulceration, most often deep and painful, covering a large area with the presence of advanced necrosis and destruction of the surrounding tissue. The most common location proved to be the cervical-cephalic area. The most popular treatment included steroids with cyclophosphamide.
Discussion: The rarity of the coexistence of these two diseases results in a lack of effective therapy. In such cases sulfone derivatives are still effective and ...
Source: Postepy higieny i medycyny doswiadczalnej - March 17, 2016 Category: Research Tags: Original article Source Type: research
Postepy Hig Med Dosw 2016; 70:200-209 "Liposomes as non-viral carriers for genetic drugs"
Methods in cancer therapy particularly in recent years, are rapidly changing, due to the need of design of new, more effective therapeutic strategies. Very promising approach to treatment of the neoplastic diseases is antisense gene therapy. Due to the low toxicity of treatment and eliminating not only the symptoms but also the molecular causes of the disease it may represent a breakthrough in cancer therapies. Delivery of a therapeutic DNA or RNA oligonucleotides to the target cells in vivo requires suitable carrier system. Non-viral drug carriers are increasingly used in new systems of targeted gene therapy. This review ...
Source: Postepy higieny i medycyny doswiadczalnej - March 17, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:194-199 "Rola limfocytów IRA B w wybranych procesach zapalnych"
The first report about the discovery of new, previously unknown immune cells named IRA B cells (innate response activator B cells) appeared in 2012. So far, their presence has been verified in both mice and humans. However, IRA B cells belong to the family of B lymphocytes and have a number of characteristics unique to this group of cells. IRA B cells are formed from activated B1a lymphocytes after their contact with a pathogen. B1a lymphocytes mainly reside within body cavities. Activated by the pathogen, they move on into secondary lymphoid organs (spleen, lymph nodes) where they differentiate into IRA B cells. IRA B cel...
Source: Postepy higieny i medycyny doswiadczalnej - March 17, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:186-193 "Nicotine-induced resistance of non-small cell lung cancer to treatment – possible mechanisms"
Cigarette smoking is the leading risk factor of lung cancer. Data from several clinical studies suggest that continuation of smoking during therapy of tobacco-related cancers is associated with lower response rates to chemotherapy and/or radiotherapy, and even with decreased survival. Although nicotine – an addictive component of tobacco – is not a carcinogen, it may influence cancer development and progression or effectiveness of anti-cancer therapy. Several in vitro and in vivo trials have evaluated the influence of nicotine on lung cancer cells. The best known mechanisms by which nicotine impacts cancer biology invo...
Source: Postepy higieny i medycyny doswiadczalnej - March 5, 2016 Category: Research Tags: Review article Source Type: research
Postepy Hig Med Dosw 2016; 70:180-185 "Serum carnitine concentration is decreased in patients with Lyme borreliosis"
Conclusions: LB patients exhibit a significant decrease of their serum carnitine concentrations. The largest changes were in the NB and PLD patients. To prevent late complications of the disease a possibility of early supplementation with carnitine should be considered. Further studies are required to explain the pathophysiological significance of our findings. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - March 5, 2016 Category: Research Tags: Original article Source Type: research
