Postepy higieny i medycyny doswiadczalnej This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Postepy Hig Med Dosw 2017; 71:328-340 "Bacteriocins from lactic acid bacteria as an alternative to antibiotics"
Bacteriocins are ribosomally synthesized, proteinaceous substances that inhibit the growth of closely related species through numerous mechanisms. The classification system used in this review divided bacteriocins into four sub-groups based on their size. Currently, there is extensive research focused on bacteriocins and their usage as a food preservative. The increasing incidence of multidrug resistant bacterial pathogens is one of the most pressing medical problems in recent years. Recently, the potential clinical application of LAB (Lactic Acid Bacteria) bacteriocin has been the subject of investigations by many scient...
Source: Postepy higieny i medycyny doswiadczalnej - May 5, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:315-327 "Aflatoxins: characteristics and impact on human health"
Some molds commonly occurring in the natural environment produce mycotoxins in the process of secondary metabolism. Aspergillus flavus and A. parasiticus are species of molds, which are responsible for the production of aflatoxins and are crucial in the pathogenesis of human diseases. Aspergillus species present in decaying plants, the soil and their spores are transferred via air currents and insects to crops and food storages. Aflatoxins B1, B2, G1, G2, M1 and M2 are the most common derivatives of aflatoxins. Ingestion of contaminated food is the main source of exposure to aflatoxins, which adversely affect the health of...
Source: Postepy higieny i medycyny doswiadczalnej - May 5, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:307-314 "Glucose tolerance disorders during treatment with glucocorticoids in patients with inflammatory diseases of the musculoskeletal system – based on the analysis of data from the literature and own research results"
Glucocorticoids are among the most frequently used anti-inflammatory and immunosuppressive drugs. They are widely used in the treatment of numerous autoimmune disorders. However, the treatment with glucocorticoids is connected with the risk of a number of side effects. Among them, glucose tolerance disorders play an important role. The results of meta-analyses show that the risk of diabetes is from 1.4 to 2.5 times higher in the case of treated patients in comparison to the general population. Glucocorticoids can directly impair pancreatic β -cell secretion. Nevertheless, a crucial role in the hyperglycemic activity seems...
Source: Postepy higieny i medycyny doswiadczalnej - May 4, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:291-306 "Lysosomal dysfunction in neurodegenerative diseases"
Dane literaturowe z ostatnich lat jednoznacznie wskazuj ą na udzia ł lizosom ó w w programowanej ś mierci kom ó rki. Dysfunkcje lizosom ó w upo ś ledzaj ą fuzj ę autofagosom ó w z lizosomami, co prowadzi do wakuolizacji cytoplazmy. Obecno ś ć wakuoli autofagalnych ob ł adowanych uszkodzonymi organellami i nieprawid ł owymi bia ł kami jest cech ą charakterystyczn ą wielu chor ó b neurodegeneracyjnych. Agregacja niezdegradowanego materia ł u zaburza homeostaz ę kom ó rki powoduj ą c ś mier ć neuronu w wyniku apoptozy i/lub nekrozy. Ponadto indukowany kalpainami lub spowodowany mutacjami rozpad b ł on...
Source: Postepy higieny i medycyny doswiadczalnej - May 4, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:281-290 "Chemotherapy and plasma adipokines level in patients with colorectal cancer"
Adipokines are molecules produced and secreted by adipose tissue and are linked to multiple malignancies. Adipokines can suppress or promote particular cell behaviors in different types of cancer. The aim of this study was to investigate the impact of chemotherapy on select adipokines in patients with colorectal cancer (CRC). Blood samples were collected from 42 patients with pathologically documented advanced CRC, who required palliative chemotherapy. Leptin, adiponectin, resistin and visfatin levels were measured by ELISA before and 3 months after the administration of chemotherapy. Among the 42 patients evaluated, 18 a...
Source: Postepy higieny i medycyny doswiadczalnej - April 12, 2017 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2017; 71:267-280 "Vegetables and fruit, as a source of bioactive substances, and impact on memory and cognitive function of elderly"
The phenomenon of population aging is not only associated with an increase in the number and proportion of older people in society, but also with an increase in the incidence of cognitive impairment. This can impair the functioning of the elderly in everyday life, work and social life participation and impair their quality of life. Hence, it is important to identify the protective factors. Neurodegenerative changes are closely linked to inflammatory processes and oxidative stress. Diet is of great importance, with particular attention being paid to the adequate intake of fruits and vegetables, due to their proven health be...
Source: Postepy higieny i medycyny doswiadczalnej - April 12, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:254-266 "Immunoregulatory role of B lymphocytes in alloresponse to kidney transplant"
B cells are a group of diverse phenotype and function subsets, which can both stimulate and inhibit the immune response to an allograft. They participate in the rejection process by influencing differentiation, proliferation and effector functions of T lymphocytes. B cells injure the graft via the ADCC (antibody-dependent cellular cytotoxicity) reaction and humoral rejection through plasmocyte production of donor-specific antibodies. A converse, suppressive mode of B cells can attribute to the development of tolerance and protect the graft from rejection. This function is provided by the regulatory B cells, which negative...
Source: Postepy higieny i medycyny doswiadczalnej - April 12, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:243-253 "The use of selected neutrophil protein plasma concentrations in the diagnosis of Crohn ’ s disease and ulcerative colitis – a preliminary report"
Conclusions: The diagnostic characteristics of plasma granulocyte protein concentrations indicate the usefulness of these tests in the diagnosis of IBD. Higher HLE- α 1AT and lactoferrin/NEU ratios in patients with UC than with CD may suggest the usefulness of these ratios in differential diagnostics. Plasma calprotectin and lactoferrin levels may be useful in CD activity assessment. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - April 11, 2017 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2017; 71:236-242 "The influence of TSA and VPA on the in vitro differentiation of bone marrow mesenchymal stem cells into neuronal lineage cells: Gene expression studies"
Discussion: The central findings of our study are that TSA and VPA affect the expression of neuronal lineage genes in an rMSCs culture. After exposure to TSA or VPA, the expression of early neuronal gene decreases but equally the expression of mature neuron genes increases. After TSA and VPA treatment ER of the oligodendrocyte progenitor marker decreased. TSA and VPA inhibit cell proliferation and the formation of neurospheres in rMSCs culture. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - March 27, 2017 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2017; 71:227-235 "Polyphenols in preventing endothelial dysfunction"
One of the main causes of mortality in developed countries is atherosclerosis. The pathogenesis of atherosclerosis is associated with endothelial dysfunction. Consumption of food rich in natural antioxidants including polyphenols significantly improves endothelial cells functions. Polyphenols have a beneficial effect on the human body and play an important part in protecting the cardiovascular system. Polyphenols present in food have antioxidant, anti-inflammatory, antihypertensive, antithrombotic and antiproliferative properties. Catechins cause an increase in the activity of endothelial nitric oxide synthase (eNOS) and ...
Source: Postepy higieny i medycyny doswiadczalnej - March 27, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:220-226 "Fecal microbiota transplantation – methods of treatment of recurrent Clostridium difficile infections and other diseases"
Clostridium difficile is a serious epidemiological problem and particularly dangerous microorganism causing hospital infections. Currently, the treatment of C. difficile infections is the use of metronidazole or vancomycin. However, in some patients, recurrent infection difficult to treat occurs. Fecal microbiota transplantation (FMT) is a new method used to treat the recurrent CDI. FMT consists in the infusion of the fecal suspension from a healthy donor into the gastrointestinal tract of a patient with CDI to restore the natural intestinal microflora. FMT is safe and effective treatment of recurrent CDI. FMT is extensive...
Source: Postepy higieny i medycyny doswiadczalnej - March 27, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:214-219 "Diversity of extended-spectrum beta-lactamase-producing Escherichia coli rods"
Conclusions: Our results show a high degree of genetic diversity of extended-spectrum beta-lactamase-producing E. coli isolates. However, based on a similarity of ≥ 80%, almost 75% of E. coli isolates were clonally related. Although it is difficult to identify definitive transmission events based on the recovery of indistinguishable pulsed-field gel electrophoresis types alone, we speculate that extended-spectrum beta-lactamase-producing E. coli strains may have disseminated throughout the hospital. (Source: Postepy higieny i medycyny doswiadczalnej)
Source: Postepy higieny i medycyny doswiadczalnej - March 27, 2017 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2017; 71:205-213 "Genetic and psychosocial factors for benzodiazepine addiction. An analysis based on the results of the authors ’ own research conducted in a group of benzodiazepine addicted and non-addicted individuals"
Purpose: In spite of the fact that the addictive potential of benzodiazepine (BDZ) drugs has been known for a long time, benzodiazepine addiction remains a common problem for psychiatry to deal with. The etiology of benzodiazepine addiction is very complex. Among the risk factors, the course of the treatment, demographic status and psychological features of a patient seem to play an important role. The aim of this study was to investigate both psychological and genetic factors differentiating benzodiazepine addicts from non-addicted users. Methods: We analysed a cohort of 120 individuals treated with benzodiazepines divid...
Source: Postepy higieny i medycyny doswiadczalnej - March 13, 2017 Category: Research Tags: Original article Source Type: research

Postepy Hig Med Dosw 2017; 71:198-204 "Prevalence and factors promoting the occurrence of vitamin D deficiency in the elderly"
Vitamin D deficiency affects a large part of the population of elderly people, especially women, who live in moderate climate countries due to a reduced amount of vitamin D in the diet (small sea fish consumption) and reduced content of 7-dehydrocholesterol, which causes decreased skin synthesis. The lowest seasonal concentration of 25(OH)D3 is usually observed during winter and spring. Sun exposure influences 25(OH)D3 concentration more strongly in men than in women. Sociodemographic factors that increase the risk of vitamin D deficiency in the elderly include poor environmental conditions, low economic status, lower edu...
Source: Postepy higieny i medycyny doswiadczalnej - March 13, 2017 Category: Research Tags: Review article Source Type: research

Postepy Hig Med Dosw 2017; 71:186-197 "Aspects of pericytes and their potential therapeutic use"
Pericytes, which are multi-potential stem cells, co-create the walls of the microvessels: capillaries, terminal arterioles and postcapillary venules. These cells are localized under the basement membrane, tightly encircling the endothelium. The most frequently mentioned molecular markers of pericytes include NG2 (neural-glial antigen 2), β -type platelet-derived growth factor receptor (PDGFR β ), smooth muscle α -actin ( α -SMA), regulator of G protein signalling 5 (RGS5), the adhesion protein CD146 and nestin. Different functions in physiological processes are assigned to pericytes such as maintaining the integrity an...
Source: Postepy higieny i medycyny doswiadczalnej - March 13, 2017 Category: Research Tags: Review article Source Type: research