Association between breath hydrogen-methane and glucose tolerance in patients with acute pancreatitis
This study was to investigate the GBT indicating the small intestinal bacterial overgrowth (SIBO), and investigate the link between SIBO and glucose tolerance in patients with acute pancreatitis. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Chang Nyol Paik, Dae Bum Kim, Ji Min Lee, Yeon Ji Kim, Jin-Mo Yang Tags: 3. Experimental Pancreatitis I Source Type: research
Secreted cyclophilin A levels elevate in animal models and patients with acute pancreatitis at disease early stage
Objectives Cyclophilin A (CypA) is widely expressed and significantly increased in the pancreas of a taurocholate-induced experimental acute pancreatitis (EAP) in rats. Recombinant CypA acerbates cholecystokinin-induced acinar cell injury. However, the secreted CypA (sCypA) levels has never been determined in EAP and human AP (HAP). Our objectives are to determine the concentration of circulating sCypA in EAP and HAP, as well as its correlation with disease severity. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Wenhao Cai, Priyanka Bhattacharya, Yongjian Wen, Na Shi, Tingting Liu, Wei Huang, Qing Xia, Rajarshi Mukherjee, Robert Sutton Tags: 3. Experimental Pancreatitis I Source Type: research
Investigation of CFTR and SLC26A6 transporters in the course of acute pancreatitis
Objectives Several apical ion transporters like cystic fibrosis transmembrane conductance regulator (CFTR) and the SLC26A6 anion exchanger are involved in Cl-, HCO3- and fluid secretion of pancreatic ductal cells. Previous studies have shown that impaired function of CFTR worsens the course of acute pancreatitis (AP). However, it is unclear, how AP affects the function of CFTR and SLC26A6 transporters. Therefor, our aims were to examine the expression and function of CFTR and SLC26A6 in normal and pathological conditions of the pancreas. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Gabriella F űr, Lóránd Kiss, Dénes Péter Kovács, Emese Réka Bálint, Zsolt Balla, Viktória Venglovecz, Petra Pallagi, József Maléth, Péter Hegyi, Zoltán Rakonczay Tags: 3. Experimental Pancreatitis I Source Type: research
Characterization of the function of transient receptor potential melastatin 2 in mouse pancreatic acinar cells
Objectives Ca2+ signaling is the hallmark of acute pancreatitis (AP) inducing mitochondrial damage, intra-acinar digestive enzyme activation and cell death. Thus prevention of toxic cellular Ca2+ overload is a promising therapeutic target. The transient receptor potential melastatin 2 (TRPM2) is a non-selective cation channel that plays major role in oxidative stress induced cellular Ca2+ overload in different cell types and also how it effects different ways of cell death. Although likely, its role in pancreatic acinar cells and the pathogenesis of AP was not investigated yet. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Julia Fanczal, Csaba P éter Biró, Tamara Madácsy, Zoltán Rakonczay, Péter Hegyi, József Maléth Tags: 3. Experimental Pancreatitis I Source Type: research
Heat shock protein-90 in acute severe pancreatitis: Potential risk- defining marker
Objectives Acute severe pancreatitis can lead to pancreatic necrosis, acute lung injury, SIRS and MODS. The inducible heat shock protein-90 (HSP-90) is anti-oxidative, anti-inflammatory, and cytoproductive enzyme that is induced in response to cellular stress. In acute severe pancreatitis the membrane damage of acinar cells, acting in adherence with induced heat-shock proteins (HSPs), potentially activates and releases potent hydrolytic enzymes that can cause cell membrane damage and systemic responses. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Aiste Gulla, Rima Budvytyte, Tadas Ragaliauskas, Julija Razumiene, Kestutis Strupas Tags: 3. Experimental Pancreatitis I Source Type: research
Dimethyl trisulfide: A promising drug candidate in experimental acute pancreatitis
Objectives The pathogenesis of acute pancreatitis (AP) is not well understood and the disease has no specific therapy. Previous investigations have demonstrated that hydrogen sulfide (H2S) and organic trisulfides are biologically active and have anti-inflammatory properties. Dimethyl trisulfide (DMTS) is an organic trisulfide found in some vegetables which also has analgesic effects. Our aim was to investigate whether DMTS could alleviate the severity of experimental AP. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: L óránd Kiss, Gabriella Fűr, Ahmad Totunji, Richárd Pető, Zsolt Balla, Emese Réka Bálint, Petra Pallagi, József Maléth, Viktória Venglovecz, Péter Hegyi, Zoltán Rakonczay Tags: 3. Experimental Pancreatitis I Source Type: research
Regulation of transcription factors in the ER stress recognition system during acute pancreatits
Objectives The pancreas is characterized by one of the highest protein synthesis rates in the human body. Secretory enzymes are expressed at very high transcription levels. Therefore a strict regulated protein homeostasis is necessary to prevent ER-stress. Three mayor pathways are involved in unfolded protein response (UPR) to prevent ER-stress. Here we investigated the regulation of transcription factors during acute pancreatitis. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Robert Bolsmann, Frank Ulrich Weiss, Julia Mayerle, Markus M. Lerch, Matthias Sendler Tags: 3. Experimental Pancreatitis I Source Type: research
VX-770 and VX-809 restore the expression defect of cystic fibrosis transmembrane conductance regulator caused by alcohol
Objectives Heavy alcohol intake is one of the most common causes of acute pancreatitis (AP). Our group previously showed that ethanol and fatty acids cause severe functional defect and impaired expression of the cystic fibrosis transmembrane conductance regulator (CFTR), which increases the severity of acute ethanol-induced pancreatitis. New compounds (such as Ivacaftor-VX-770 and Lumacaftor-VX-809) are available to correct the impaired CFTR function and expression in cystic fibrosis patients with specific mutations, which might be utilized in the treatment of alcohol-induced AP. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Anna Grassalkovich, J ózsef Maléth, Tamara Madácsy, Petra Pallagi, Viktória Venglovecz, Zoltán Rakonczay, Péter Hegyi Tags: 3. Experimental Pancreatitis I Source Type: research
Kynurenic acid and its novel analogue SZR-72 ameliorate experimental acute necrotizing pancreatitis in rats via NMDA-1 receptor
Objectives Background: The pathogenesis of acute pancreatitis (AP) is not well understood, the disease has no specific therapy. L-kynurenic acid (KYNA) and its analogue SZR-72 have immune modulatory roles in several inflammatory diseases. Furthermore, KYNA and SZR-72 function as antagonists of endogenous glutamate N-methyl-d-aspartate (NMDA) receptors. Aim: We investigated the effects of KYNA and SZR-72 on NMDA receptors in experimental AP. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Zsolt Balla, Bal ázs Kui, Eszter Sára Kormányos, Emese Réka Bálint, Lóránd Kiss, Béla Iványi, László Vécsei, Ferenc Fülöp, András Harazin, Mária A. Deli, Viktória Venglovecz, Tamara Madácsy, József Maléth, Péter Hegyi, Zoltan Rakoncza Tags: 3. Experimental Pancreatitis I Source Type: research
Morphological changes in the kidneys with experimental acute necrotizing pancreatitis (ANP)
Objectives Background: Pancreatitis is accompanied by the development of severe endogenous intoxication. Kidneys are quickly involved in the pathological process and don ’t cope with their function at the early stages of the disease, which leads to progression of endotoxicosis. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Pavel Rasputin, Stephen Abiola, Svetlana Andreeva, Evgeny Prokopyev Tags: 3. Experimental Pancreatitis I Source Type: research
Fentanyl impairs the severity of L-ornithine-induced experimental acute pancreatitis in rats
Objectives Pain is a predominant symptom of acute pancreatitis (AP) and opioids are widely used for its management. Barlass et al. have recently demonstarted that morphine treatment worsened the severity of AP in mice. Due to its good safety profile, the application of fentanyl in AP is increasing. In our study, we aimed to assess the effect of fentanyl on AP severity. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Emese R éka Bálint, Zsolt Balla, Balázs Kui, Lóránd Kiss, Gabriella Fűr, Viktória Venglovecz, Petra Pallagi, József Maléth, Péter Hegyi, Zoltán Rakonczay Tags: 3. Experimental Pancreatitis I Source Type: research
Matricellular protein SPARC determines severity but not regeneration of caerulein-induced pancreatitis in mice
Objectives SPARC (secreted protein acidic and rich in cysteine) is a matricellular protein and has been implicated in wound healing, cell migration and regeneration processes. Upon inflammatory or neoplastic stimuli, SPARC is predominantly activated in fibroblasts. In the present study, we investigate the impact of genetic SPARC ablation during the course of acute, caerulein-induced pancreatitis in mice. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Laurin Wolf, Robert Goetze, Roberta Roggiolani, Iswarya Ramu, Volker Ellenrieder, Elisabeth Hessmann, Albrecht Neesse Tags: 3. Experimental Pancreatitis I Source Type: research
IRAK-M regulates the local and systemic immune responses in acute pancreatitis
Objectives Acute pancreatitis is characterized by premature intracellular activation of digestive enzymes which leads to self-destruction of the pancreas and a successive systemic inflammatory response. Toll-like receptors (TLRs) are innate immune sensing components which recognize damage-associated molecular patterns (DAMPs) in the injured pancreas. They activate the NF- κB pathway by myeloid differentiation primary response gene 88 (MyD88) and the phosphorylation of IL-1 receptor-associated kinases (IRAKs). (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Franziska Gisela Thiel, Frank Ullrich Weiss, Markus M. Lerch, Matthias Sendler Tags: 3. Experimental Pancreatitis I Source Type: research
Pink1-Parkin mediated mitophagy in acute pancreatitis
Objectives Acute pancreatitis (AP) is characterized by premature activation of digestive proteases within the pancreas, resulting in cell death. Previously it has been reported that mitochondrial dysfunction and impaired autophagy contribute to the pathogenesis of AP. Except for their main role in energy production, mitochondria have also been implicated in fundamental cellular processes such as ion homeostasis, lipid metabolism, and the initiation of apoptotic cell death. However, the inter-relationship between mitochondrial dysfunction and cell death in acute pancreatitis remains elusive.We investigated the role of Pink1...
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Preshit Ravindra Wagh, Matthias Sendler, Ujjwal Mukund Mahajan, Danniel Jhon, Frank Ulrich Weiss, Markus M. Lerch, Julia Mayerle Tags: 3. Experimental Pancreatitis I Source Type: research
The effect of CFTR Cl- channel in the exocrine/endocrine pancreas under pathological conditions
Objectives The exocrine and endocrine part of the pancreas work in close interaction with each other in which the CFTR Cl- channel plays an essential role by regulating the secretory processes. The role of the channel under certain pathological conditions is not completely known, therefore our aim in this study was to investigate the exocrine and endocrine functions in diabetic and/or pancreatitis-induced mice in wild-type (WT) and CFTR knock out (KO) animals. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Attila Ébert, Glória Stefán, Emese Tóth, Petra Pallagi, Péter Hegyi, Viktória Venglovecz Tags: 3. Experimental Pancreatitis I Source Type: research
