VX-770 and VX-809 restore the expression defect of cystic fibrosis transmembrane conductance regulator caused by alcohol
Objectives Heavy alcohol intake is one of the most common causes of acute pancreatitis (AP). Our group previously showed that ethanol and fatty acids cause severe functional defect and impaired expression of the cystic fibrosis transmembrane conductance regulator (CFTR), which increases the severity of acute ethanol-induced pancreatitis. New compounds (such as Ivacaftor-VX-770 and Lumacaftor-VX-809) are available to correct the impaired CFTR function and expression in cystic fibrosis patients with specific mutations, which might be utilized in the treatment of alcohol-induced AP.
Source: Pancreatology - Category: Gastroenterology Authors: Anna Grassalkovich, J ózsef Maléth, Tamara Madácsy, Petra Pallagi, Viktória Venglovecz, Zoltán Rakonczay, Péter Hegyi Tags: 3. Experimental Pancreatitis I Source Type: research