BISAP score - a predictor of mortality, pancreas necrosis, organ failure and disease severity in patients with acute pancreatitis - single center experience (Clinical Center of Montenegro)
Objectives The Bedside Index for Severity in Acute Pancreatitis (BISAP) score has been developed to identify patients at high risk for mortality or severe disease early during the course of acute pancreatitis (AP). The purpose of this study was to explore the early evaluations of BISAP score in predicting the severity, pancreas necrosis (PN), organ failure (OF) and mortality of AP. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Milos Lukic, Rade Boricic, Damir Muhovic, Brigita Smolovic Tags: 1. Acute Pancreatitis I Source Type: research
Explore the childhood onset pancreatitis with the support of APPLE (Analysis of Pediatric Pancreatitis) multicenter, observational, clinical trial
Objectives Despite the rising incidence of pediatric pancreatitis (PP) in the last decade, there is still lack of information concerning the management of childhood-onset pancreatitis. The Pediatric Session of the Hungarian Pancreatic Study Group has initiated a prospective international observational clinical trial (APPLE - Analysis of Pediatric Pancreatitis) to understand the genetic factors of all forms of pancreatitis occurred under 18 years of age (APPLE-R), and to collect a critical mass of clinical data and biomedical research samples from children suffering from PP (APPLE-P). (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Andrea P árniczky, Balázs Csaba Németh, Dóra Mosztbacher, Andrea Szentesi, Alexandra Demcsák, Anna Zsófia Tóth, Natália Lásztity, Judit Czelecz, István Tokodi, Orsolya Kadenczki, Kinga Kaán, Félix Márk Juhász, Gábor Veres, Erika Tomsits, Al Tags: 2. Pancreatitis in children Source Type: research
The way from abdominal pain to pediatric pancreatitis - The PINEAPPLE study
Objectives The documented incidence of pediatric pancreatitis (PP) is low, but it shows a rising pattern from Eastern to Western Europe and the USA. The cause of this phenomenon is not clear, but based on a single center study the amylase and lipase measurements correlate with the incidence of the disease. The aim of the PINEAPPLE study is to investigate the current diagnostic practice for PP and to estimate the occurrence of pancreatitis among children suffering from abdominal pain worldwide. Furthermore we would like to develop an EBM guideline to establish a scoring system in order to evaluate the necessity of diagnosti...
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: D óra Mosztbacher, Andrea Párniczky, Anna Tóth, Alexandra Demcsák, Veronika Ila, Maisam Abu El Haija, Flora Szabo, István Tokodi, Boglárka Fehér, Károly Bakó, Orsolya Kadenczki, Ildikó Guthy, Irina Cazacu, Kinga Kaán, Félix Juhász, Enikő Hor Tags: 2. Pancreatitis in children Source Type: research
Opposite effects of younger and older ages on severity and mortality in Acute Pancreatitis. A meta-analysis based on 191 678 patients
In this study we aimed to investigate whether ageing has any effects on severity or mortality in AP. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Katalin M árta, Alina-Marilena Lazarescu, Nelli Farkas, Irina-Mihaela Cazacu, Máté Ottófy, Péter Hegyi, Hungarian Pancreatic Study Group Tags: 2. Pancreatitis in children Source Type: research
Clinical signs of severity and therapeutic intervention in pediatric acute pancreatitis – prospective multicenter nation-wide cohort
Objectives Pediatric acute pancreatitis (AP) has a rising incidence, also different etiologic factors, the role of genetic mutations has been revealed in past years. Predicting severity of disease and optimal management of pediatric AP is still the main goal of many researchers. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Nat ália Lásztity, Dóra Mosztbacher, Anna Zsófia Tóth, Alexandra Demcsák, István Tokodi, Judit Czelecz, Kinga Kaán, Félix Márk Juhász, Gábor Veres, Alexandra Tészás, Ibolya Vass, András Tárnok, Erika Tomsits, Andrea Szentesi, Péter Hegyi, Tags: 2. Pancreatitis in children Source Type: research
Estimation of ultrasound attenuation as a method for diagnostics of pancreatic steatosis in children
Objectives To assess the diagnostic value of quantitative estimation of ultrasound attenuation of the pancreas in the prediction of pancreatic steatosis in children. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Olha Lukianenko, Yuriy Stepanov, Nataliya Zavhorodnia, Nina Hravirovska, Iryna Konenko Tags: 2. Pancreatitis in children Source Type: research
Risk factor for diabetes mellitus in pediatric chronic pancreatitis patients
This study aimed to identify the incidence of and risk factors for DM in pediatric CP. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Lu Hao, Yu Liu, Di Zhang, Ya-Wei Bi, Zhuan Liao, Zhao-Shen Li, Liang-Hao Hu Tags: 2. Pancreatitis in children Source Type: research
Does the pancreas divisum reflect the clinical course of chronic pancreatitis in children?
Objectives Chronic pancreatitis (CP) among children is a rare entity with a diverse etiology. Major risk factors of the disease include gene mutations, biliary diseases, lipid disorders and anatomical defects of pancreatic duct. The leading anomaly from the latter is pancreas divisum (PD), which role in etiology and clinical course of CP remains controversial. The aim of the study was to analyse the clinical presentation of CP associated with pancreas divisum (group 1) in comparison with CP related to other risk factors (group 2). (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Karolina Wejnarska, Elwira Kolodziejczyk, Agnieszka Magdalena Rygiel, Jerzy Bal, Grzegorz Oracz Tags: 2. Pancreatitis in children Source Type: research
Risk Factor for Steatorrhea in Pediatric Chronic Pancreatitis Patients
This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best knowledge, there is no pediatric study to document the natural history of steatorrhea in CP. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Lu Hao, Yu Liu, Teng Wang, Ya-Wei Bi, Zhuan Liao, Zhao-Shen Li, Liang-Hao Hu Tags: 2. Pancreatitis in children Source Type: research
The prevalence of acute and chronic pancreatitis in Polish children
Objectives Acute (AP) and chronic pancreatitis (CP) are rare entities in children. The prevalence of AP among children is estimated for 2-13/100.000 per year, and there are no reliable data concerning CP. To date, there were no studies investigating the morbidity and prevalence of pancreatic diseases among Polish children, therefore we aimed to analyze that issue. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Karolina Wejnarska, Marek Woynarowski, Micha ł Wasilewicz, Andrzej Baniukiewicz, Aneta Lichwierowicz, Michal Maluchnik, Grzegorz Oracz Tags: 2. Pancreatitis in children Source Type: research
Genetic inhibition of cyclophilin D protects against bile acid or ethanol and fatty acid induced pancreatic ductal epithelial cell damage in mice
Objectives Mitochondrial dysfunction is a hallmark of several disease pathogenesis including acute pancreatitis (AP). Our previous results suggest that mitochondrial damage is crucial in bile acid induced inhibition of pancreatic ductal HCO3- secretion, however the details of mitochondrial function and dysfunction in pancreatic ductal epithalial cells (PDEC) is not known yet. Cyclophilin D (Cyp D) has a crucial role in the opening of the mitochondrial transition pore (mPTP) which could be a target to avoid mitochondrial Ca2 + overload and cell death . (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Emese T óth, József Maléth, Réka Erdős, Noémi Závogyán, László Tretter, Gergő Horváth, Zoltán Rakonczay, Péter Hegyi Tags: 3. Experimental Pancreatitis I Source Type: research
Factors ensuring the appearance and disappearance of the autoimmune component in pancreatic injury in rats
Objectives Introduction. Long-term, often recurrent diseases of the digestive system (acute and chronic pancreatitis) are accompanied by the presence of an autoimmune component. The cause of this complication is not clear. Aim. Study was to identify the factors ensuring the appearance and disappearance of the autoimmune component. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Irina Trubitsyna, Ludmila Vinokurova, Tatyana Tarasova, Anna Smirnova, Andrey Gulyaev, Zaira Abdulatipova, Julia Orlova Tags: 3. Experimental Pancreatitis I Source Type: research
Characterization of the Orai1 mediated Ca2+ entry in mouse pancreatic ductal cells
Objectives Acute pancreatitis (AP) is a severe inflammatory disorder with significant mortality and no treatment, urging the identification of novel drug targets. Toxic intracellular Ca2+ overload is the hallmark of AP pathogenesis and the inhibition of the plasma membrane Ca2+ channel Orai1 in pancreatic acinar cells markedly decreased the Ca2+ toxicity and the severity of AP, but we have no information about the role of Orai1 mediated Ca2+ influx in pancreatic ductal cell (PDC) functions. We aimed to clarify the role of Orai1 in pancreatic ductal physiology and pathophysiology. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Marietta G örög, Anna Grassalkovich, Tamara Madácsy, Noémi Papp, Anita Balázs, Petra Pallagi, Zoltán Rakonczay, Péter Hegyi, József Maléth Tags: 3. Experimental Pancreatitis I Source Type: research
An in vitro system to evaluate potential therapeutic substances for ER stress reduction during pancreatitis
Objectives The acinar cells of the pancreas are highly efficient protein synthesis units that produce large amounts of secretory enzymes. Disturbances in normal function of the endoplasmic reticulum (ER) activate an evolutionarily conserved cell stress response. The unfolded protein response (UPR), is aimed at preventing cellular damage and was found to be activated also during pancreatitis. One crucial signal pathway induces through Inositol-requiring kinase 1 (IRE-1) an alternative splicing of XBP-1 mRNA which results in generation of the XBP-1s isoform, a transcription factor which helps to adapt the folding capacity of...
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Jana Marielle Modenbach, Frank Ulrich Weiss, Manuel Gronbach, Christina Oppermann, Firas El-Hage, Jola Pospech, Markus M. Lerch, Matthias Sendler Tags: 3. Experimental Pancreatitis I Source Type: research
Genetic knockout of SARI does not affect the severity of caerulein-induced acute pancreatitis in mice
Objectives SARI (suppressor of activator protein-1, regulated by interferon) is a novel gene with anti-inflammatory and tumour suppressive effects. SARI expression occurs in diverse tissues, highest in the pancreas. We sought to assess the role of SARI in experimental acute pancreatitis (EAP). To investigate the effect of SARI knockout (SARI-/-) on the severity of EAP. (Source: Pancreatology)
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Chenxia Han, Lei Dai, Shi Na, Tingting Liu, Xiaoying Zhang, Robert Sutton, Wei Huang, Hongxin Deng, Qing Xia Tags: 3. Experimental Pancreatitis I Source Type: research
