Characterization of the Orai1 mediated Ca2+ entry in mouse pancreatic ductal cells

Objectives Acute pancreatitis (AP) is a severe inflammatory disorder with significant mortality and no treatment, urging the identification of novel drug targets. Toxic intracellular Ca2+ overload is the hallmark of AP pathogenesis and the inhibition of the plasma membrane Ca2+ channel Orai1 in pancreatic acinar cells markedly decreased the Ca2+ toxicity and the severity of AP, but we have no information about the role of Orai1 mediated Ca2+ influx in pancreatic ductal cell (PDC) functions. We aimed to clarify the role of Orai1 in pancreatic ductal physiology and pathophysiology.
Source: Pancreatology - Category: Gastroenterology Authors: Tags: 3. Experimental Pancreatitis I Source Type: research