Lymphadenectomy in pancreatic neuroendocrine neoplasms: Why are we still debating?
Pancreatic Neuroendocrine Neoplasms (PNEN) are rare tumours exhibiting very heterogeneous behaviour. For these reasons, studies with high level of evidence are lacking. Whether lymphadenectomy should be performed for PNEN is a matter of debate. In this review, we perform a critical analysis of the available literature regarding the clinical significance of lymphnode metastases, the importance of lymphadenectomy, and the implications on disease-specific survival. (Source: Pancreatology)
Source: Pancreatology - September 19, 2018 Category: Gastroenterology Authors: F. Ausania, P. Senra del Rio Source Type: research
Dilemma of elevated CA 19-9 in biliary pathology
Carbohydrate antigen 19-9 (CA 19-9) is a tumor marker which has been extensively evaluated and widely utilized primarily in diagnosing and prognosticating pancreaticobiliary malignancies. Levels may be significantly influenced and elevated in cases of benign biliary conditions however, especially in obstructive jaundice, thereby posing difficulty in distinguishing between benign and malignant cholestasis. A myriad of studies have focused on elucidating proper use and interpretation of CA 19-9 in pancreatic cancer as well as in the setting of cholestasis. (Source: Pancreatology)
Source: Pancreatology - September 18, 2018 Category: Gastroenterology Authors: Adrianne Tsen, Mary Barbara, Laura Rosenkranz Source Type: research
Diagnosis, treatment and long-term outcome of autoimmune pancreatitis in Sweden
Autoimmune pancreatitis (AIP) is a pancreatic inflammatory process characterized by a strong inflammatory cell infiltration and two histopathologically distinct subtypes: type 1 and type 2. Diagnosis is often challenging and requires a combination of clinical, laboratory and imaging data. AIP can mimic pancreatic tumours leading to unnecessary resections if not correctly diagnosed. Short- and long-term outcomes of AIP have been poorly investigated so far and no large series have been previously reported from Sweden. (Source: Pancreatology)
Source: Pancreatology - September 13, 2018 Category: Gastroenterology Authors: Miroslav Vujasinovic, Roberto Valente, Pia Maier, Victoria von Beckerath, Stephan L. Haas, Urban Arnelo, Marco Del Chiaro, Nikolaos Kartalis, Raffaella Maria Pozzi-Mucelli, Carlos Fernandez-Moro, Caroline Sophie Verbeke, Jingru Yu, Weimin Ye, J. Matthias Source Type: research
Portal encasement: Significant CT findings to diagnose local recurrence after pancreaticoduodenectomy for pancreatic cancer
To demonstrate the utility of portal encasement as a criterion for early diagnosis of local recurrence (LR) after pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC). (Source: Pancreatology)
Source: Pancreatology - September 10, 2018 Category: Gastroenterology Authors: Tamaki Noie, Yasushi Harihara, Masaaki Akahane, Junichi Kazaoka, Astuki Nagao, Shoichi Sato, Kazuteru Watanabe, Satoshi Nara, Kaoru Furushima, Ryuji Yoshioka, Yukinori Yamagata, Emiko Takeshita, Takashi Okuyama, Shinichi Sameshima, Masatoshi Oya Source Type: research
Different biological behaviors in left-sided pancreatic cancer according to Yonsei criteria: Proposal of a modified Yonsei criteria score
In this study, we investigated whether left-sided pancreatic cancer with YC can be more individualized to predict long-term survival by using clinically and pathologically detectable parameters. (Source: Pancreatology)
Source: Pancreatology - September 3, 2018 Category: Gastroenterology Authors: Seoung Yoon Rho, Mi Jin Yun, Chang Moo Kang, Sung Hwan Lee, Ho Kyoung Hwang, Woo Jung Lee Source Type: research
Comparison between groove carcinoma and groove pancreatitis
The pancreatoduodenal groove (anatomical groove) is a potential space bordered by the head of the pancreas, duodenum, and common bile duct. Discerning between groove carcinoma (GC) and groove pancreatitis (GP) is often difficult, but clinically important. We retrospectively analyzed and compared the findings of computed tomography (CT), laboratory tests, and endoscopic ultrasound-fine needle aspiration (EUS-FNA) for GC and GP. (Source: Pancreatology)
Source: Pancreatology - August 29, 2018 Category: Gastroenterology Authors: Jae Hyuck Jun, Sung Koo Lee, So Yeon Kim, Dong Hui Cho, Tae Jun Song, Do Hyun Park, Sang Soo Lee, Dong-Wan Seo, Myung-Hwan Kim Source Type: research
Guidelines for the Diagnostic Cross Sectional Imaging and Severity Scoring of Chronic Pancreatitis
The paper presents the international guidelines for imaging evaluation of chronic pancreatitis. The following consensus was obtained: Computed tomography (CT) is often the most appropriate initial imaging modality for evaluation of patients with suspected chronic pancreatitis (CP) depicting most changes in pancreatic morphology. CT is also indicated to exclude other potential intraabdominal pathologies presenting with symptoms similar to CP. However, CT cannot exclude a diagnosis of CP nor can it be used to exclusively diagnose early or mild disease. (Source: Pancreatology)
Source: Pancreatology - August 28, 2018 Category: Gastroenterology Authors: Jens Br øndum Frøkjær, Fatih Akisik, Ammad Farooq, Burcu Akpinar, Anil Dasyam, Asbjørn Mohr Drewes, Ingfrid S. Haldorsen, Giovanni Morana, John P. Neoptolemos, Søren Schou Olesen, Maria Chiara Petrone, Andrea Sheel, Tooru Shimosoegawa, David C. Whitc Source Type: research
The radiotherapy-sensitization effect of cantharidin: Mechanisms involving cell cycle regulation, enhanced DNA damage, and inhibited DNA damage repair
Cantharidin is an inhibitor of protein phosphatase 2 A (PP2A), and has been frequently used in clinical practice. In our previous study, we proved that cantharidin could arrest cell cycle in G2/M phase. Since cells at G2/M phase are sensitive to radiotherapy, in the present study, we investigated the radiotherapy-sesitization effect of cantharidin and the potential mechanisms involved. (Source: Pancreatology)
Source: Pancreatology - August 24, 2018 Category: Gastroenterology Authors: Meng-Dan Xu, Shu-Ling Liu, Bei-Bei Zheng, Jing Wu, Meng-Yao Wu, Yan Zhang, Fei-Ran Gong, Min Tao, Junning Zhang, Wei Li Source Type: research
Overexpression of GP73 promotes cell invasion, migration and metastasis by inducing epithelial-mesenchymal transition in pancreatic cancer
Pancreatic cancer is one of the most difficult clinical cases to diagnose with a very low 5-year survival rate of 5%, regardless of the advances made in both the medical and surgical treatment of the disease. One of the contributing factors for the high mortality rate seen of pancreatic cancer patients is the lack of effective chemotherapies, which is believed to be due to drug-resistance. Based on recent evidence, epithelial-mesenchymal transition (ETM) of pancreatic cancer cells has been found to be associated with the development of drug resistance and an increase in cell invasion. (Source: Pancreatology)
Source: Pancreatology - August 23, 2018 Category: Gastroenterology Authors: Yin-Xue Song, Zhi-Chao Xu, Hui-Ling Li, Pei-Lei Yang, Jun-Kai Du, Jing Xu Source Type: research
Silencing of TRPM8 inhibits aggressive tumor phenotypes and enhances gemcitabine sensitivity in pancreatic cancer
The transient receptor potential TRPM8 ion channel is required for cellular proliferation in pancreatic epithelia and adenocarcinoma. To elucidate the mechanism that mediates the function of TRPM8, we examined its role in the proliferation and invasion of pancreatic cancer (PC) cells. TRPM8 expression increased in both the PC tissues and cell lines; a high TRPM8 expression was correlated with poorer prognosis in patients with PC. In PC cell lines, PACN-1 and BxPC-3, Ca2+ influxes could be evoked by TRPM8; the sensitivity of PC cells to gemcitabine was increased, while the proliferation and invasion of PC cells were suppres...
Source: Pancreatology - August 22, 2018 Category: Gastroenterology Authors: JieFeng Liu, GuoHuang Hu, YuJing Gong, QianLe Yu, Bin He, WangHao Li, ZhiGuo He, WenJie Hao, ZiChao He, YiPing Liu Source Type: research
An audit of percutaneous drainage for acute necrotic collections and walled off necrosis in patients with acute pancreatitis
Percutaneous catheter drainage (PCD) is used as a first step in the management of symptomatic fluid collections in patients with acute pancreatitis (AP). We aimed to compare the outcome of patients with acute necrotic collection (ANC) and those with walled-off necrosis (WON), who had undergone PCD as a part of management of AP. (Source: Pancreatology)
Source: Pancreatology - August 20, 2018 Category: Gastroenterology Authors: Bipadabhanjan Mallick, Narendra Dhaka, Pankaj Gupta, Ajay Gulati, Sarthak Malik, Saroj K. Sinha, Thakur D. Yadav, Vikas Gupta, Rakesh Kochhar Source Type: research
Pancreatic cystosis in patients with cystic fibrosis: A qualitative systematic review
Patients with cystic fibrosis (CF) and a CFTR gene mutation may present with a variety of pancreatic disorders. The presence of multiple macrocysts (>1 cm) replacing the entire pancreatic parenchyma is termed pancreatic cystosis. Lack of clear data makes clinical decision making challenging and controversial. The aim of this review is to perform a qualitative systematic analysis of the literature with intention to evaluate management plans. (Source: Pancreatology)
Source: Pancreatology - August 17, 2018 Category: Gastroenterology Authors: Chirag S. Desai, Jennifer Shurney, Rebecca McCall, Khalid M. Khan, Todd H. Baron Source Type: research
RCAN1 is a marker of oxidative stress, induced in acute pancreatitis
To date, there still is a lack of specific acute pancreatitis markers and specifically an early marker that can reliably predict disease severity. The inflammatory response in acute pancreatitis is mediated in part through oxidative stress and calcineurin-NFAT (Nuclear Factor of Activated T-cells) signaling, which is inducing its own negative regulator, regulator of calcineurin 1 (RCAN1). Caerulein induction is a commonly used in vivo model of experimental acute pancreatitis. Caerulein induces CN-NFAT signaling, reactive oxygen species and inflammation. (Source: Pancreatology)
Source: Pancreatology - August 16, 2018 Category: Gastroenterology Authors: K. Jessica Norberg, Salvatore Nania, Xuan Li, Hui Gao, Peter Szatmary, Ralf Segersv ärd, Stephan Haas, Annika Wagman, Urban Arnelo, Robert Sutton, Rainer L. Heuchel, J. Matthias Löhr Source Type: research
RNA sequence analysis reveals pathways and candidate genes associated with liver injury in a rat pancreatitis model
The morbidity and mortality associated with acute pancreatitis (AP) are largely attributable to abnormalities that occur in distant organs, such as liver and lungs. Pancreatitis-associated liver injury (PALI) remains a serious and even fatal complication during the progression of AP. However, the exact pathophysiological mechanism is still unclear. (Source: Pancreatology)
Source: Pancreatology - August 15, 2018 Category: Gastroenterology Authors: Qian Wang, Shuanghong Lei, Yi Wang, Chaoxu Liu, Gang Wang Source Type: research
Endoscopic ultrasound appearance of pancreatic serotonin-staining neuroendocrine neoplasms
The pancreatic localization of serotonin-staining neuroendocrine neoplasms is extremely rare. This is a retrospective study aimed at analyzing the endoscopic ultrasound appearance of pancreatic serotoninoma. (Source: Pancreatology)
Source: Pancreatology - August 11, 2018 Category: Gastroenterology Authors: Sara Massironi, Stefano Partelli, Maria C. Petrone, Alessandra Zilli, Dario Conte, Massimo Falconi, Paolo G. Arcidiacono Source Type: research
