New observations on the utility of CA19-9 as a biomarker in Lewis negative patients with pancreatic cancer
This study was to examine serum CA19-9 levels in patients with pancreatic cancer according to Lewis status. (Source: Pancreatology)
Source: Pancreatology - August 9, 2018 Category: Gastroenterology Authors: Guopei Luo, Zhiyao Fan, He Cheng, Kaizhou Jin, Meng Guo, Yu Lu, Chao Yang, Kun Fan, Qiuyi Huang, Jiang Long, Liang Liu, Jin Xu, Renquan Lu, Quanxing Ni, Andrew L. Warshaw, Chen Liu, Xianjun Yu Source Type: research
The diagnostic value of Rosemont and Japanese diagnostic criteria for ‘indeterminate’, ‘suggestive’, ‘possible’ and ‘early’ chronic pancreatitis
Longitudinal data are lacking to support consensus criteria for diagnosing early chronic pancreatitis. (Source: Pancreatology)
Source: Pancreatology - August 7, 2018 Category: Gastroenterology Authors: Andrea RG. Sheel, Ryan D. Baron, Ioannis Sarantitis, Jayapal Ramesh, Paula Ghaneh, Michael GT. Raraty, Vincent Yip, Robert Sutton, Michael R. Goulden, Fiona Campbell, Ammad Farooq, Priya Healey, Richard Jackson, Christopher M. Halloran, John P. Neoptolemo Source Type: research
Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38 MAPK and ERS inhibition
To investigate the effects of quercetin on intestinal barrier disruption and inflammationin acute necrotizing pancreatitis (ANP) in rats, and its possible mechanism. (Source: Pancreatology)
Source: Pancreatology - August 6, 2018 Category: Gastroenterology Authors: Zheng Junyuan, Xu Hui, Huang Chunlan, Fan Junjie, Mei Qixiang, Lu Yingying, Lou Lihong, Wang Xingpeng, Zeng Yue Source Type: research
Patients with pancreatic cystic neoplasms can benefit from management of multidisciplinary team: Experience from a Chinese academic center
Pancreatic cystic neoplasms (PCNs) are a spectrum of neoplasms that can be benign or malignant. The accuracy of diagnosis is critical for this disease since different types of PCNs are treated differently using various modalities. The use of a multidisciplinary team (MDT) has been shown to improve the management and outcomes of various diseases. We aimed to determine the performance of MDT in the management of PCNs. (Source: Pancreatology)
Source: Pancreatology - August 1, 2018 Category: Gastroenterology Authors: Yiwen Chen, Chengxiang Guo, Qi Zhang, Yinang Shen, Yuwei Li, Xiang Li, Xueli Bai, Tingbo Liang Source Type: research
Functions of the CXC ligand family in the pancreatic tumor microenvironment
Therapeutic resistance is the major contributor to the poor prognosis of and low survival from pancreatic cancer (PC). Cancer progression is a complex process reliant on interactions between the tumor and the tumor microenvironment (TME). Members of the CXCL family of chemokines are present in the pancreatic TME and seem to play a vital role in regulating PC progression. As pancreatic tumors interact with the TME and with PC stem cells (CSCs), determining the roles of specific members of the CXCL family is vital to the development of improved therapies. (Source: Pancreatology)
Source: Pancreatology - August 1, 2018 Category: Gastroenterology Authors: Nien-Hung Lee, Mehrdad Nikfarjam, Hong He Source Type: research
Endoscopic ultrasound elastography in the diagnosis of pancreatic masses: A meta-analysis
Endoscopic ultrasound (EUS) elastography is a novel non-invasive technique that can be used for distinguishing benign from malignant pancreatic masses. However, the studies have reported widely varied sensitivities and specificities. A meta-analysis was performed to assess the performance of EUS elastography for the differentiation of benign and malignant pancreatic masses. (Source: Pancreatology)
Source: Pancreatology - July 30, 2018 Category: Gastroenterology Authors: Binglan Zhang, Fuping Zhu, Pan Li, Shishi Yu, Yajing Zhao, Minmin Li Source Type: research
Progression to pancreatic ductal adenocarcinoma from pancreatic intraepithelial neoplasia: Results of a simulation model
To gain insight into the natural history and carcinogenesis pathway of Pancreatic Intraepithelial Neoplasia (PanIN) lesions by building a calibrated simulation model of PanIN progression to pancreatic ductal adenocarcinoma (PDAC) (Source: Pancreatology)
Source: Pancreatology - July 28, 2018 Category: Gastroenterology Authors: Mary Linton B Peters, Andrew Eckel, Peter P. Mueller, Angela C. Tramontano, Davis T. Weaver, Anna Lietz, Chin Hur, Chung Yin Kong, Pari V. Pandharipande Source Type: research
Protocol digest of randomized phase II study of modified FOLFIRINOX versus gemcitabine plus nab-paclitaxel combination therapy for locally advanced pancreatic cancer: Japan clinical oncology group study (JCOG1407)
A randomized phase II selection design trial comparing FOLFIRINOX and GnP for patients with locally advanced pancreatic cancer started in July 2016. (Source: Pancreatology)
Source: Pancreatology - July 27, 2018 Category: Gastroenterology Authors: Junki Mizusawa, Akira Fukutomi, Hiroshi Katayama, Hiroshi Ishii, Tatsuya Ioka, Takuji Okusaka, Hideki Ueno, Makoto Ueno, Masafumi Ikeda, Nobumasa Mizuno, Masato Ozaka, Haruhiko Fukuda, Junji Furuse, Hepatobiliary and Pancreatic Oncology Group of the Japan Source Type: research
Increased risk of candidemia in patients with necrotising pancreatitis infected with candida species
Candida infections are frequent in necrotising pancreatitis. Candidemia is associated with very high mortality and its risk due to infected pancreatic necrosis is unknown. So we aimed to assess potential risk factors and the risk of candidemia in necrotising pancreatitis. (Source: Pancreatology)
Source: Pancreatology - July 15, 2018 Category: Gastroenterology Authors: Sebastian Rasch, Ulrich Mayr, Veit Phillip, Roland M. Schmid, Wolfgang Huber, Hana Alg ül, Tobias Lahmer Source Type: research
Genomic testing for pancreatic cancer in clinical practice as real-world evidence
Precision medicine guided by comprehensive genome sequencing represents a potential treatment strategy for pancreatic cancer. However, clinical sequencing for pancreatic cancer entails several practical difficulties. We have launched an in-house clinical sequencing system and started genomic testing for patients with cancer in clinical practice. We have analyzed the clinical utility of this system in pancreatic cancer. (Source: Pancreatology)
Source: Pancreatology - July 15, 2018 Category: Gastroenterology Authors: Hideyuki Hayashi, Shigeki Tanishima, Kyoko Fujii, Ryo Mori, Yasunobu Okamura, Emmy Yanagita, Ryosuke Matsuoka, Toraji Amano, Ichiro Kinoshita, Yoshito Komatsu, Hirotoshi Dosaka-Akita, Hiroshi Nishihara Tags: Original Article Source Type: research
Dietary oleic acid is inversely associated with pancreatic cancer – Data from food diaries in a cohort study
This study aims to clarify the relationship between dietary oleic acid intake and the risk of developing PDA using nutritional information from food diaries plus published serum biomarker data from HbA1c. (Source: Pancreatology)
Source: Pancreatology - July 10, 2018 Category: Gastroenterology Authors: Paul JR. Banim, Robert Luben, Kay-Tee Khaw, Andrew R. Hart Source Type: research
Knockdown of AGR2 induces cell apoptosis and reduces chemotherapy resistance of pancreatic cancer cells with the involvement of ERK/AKT axis
Pancreatic cancer (PC), an aggressive human malignancy, presents with a striking resistance to chemotherapy. Interesting, AGR2 has been found to be upregulated in various cancers and has been found to promote the dissemination of PC cells. Thereby, a series of in-vitro experiments were performed to investigate the relationship between AGR2 and the ERK/AKT axis, and to explore whether it affects PC cells. (Source: Pancreatology)
Source: Pancreatology - July 7, 2018 Category: Gastroenterology Authors: Qing-Guo Liu, Yan-Ju Li, Lan Yao Source Type: research
The prevalence of pancreatic morphological abnormalities detected by digital autopsy
Chronic pancreatitis (CP) is a chronic condition characterized by irreversible fibrosis of the pancreatic parenchyma, accompanied by calcification and dilatation of the main pancreatic duct (MPD) and its branches [1]. A more recent proposal for a new mechanistic definition consensus suggests that ‘common features of established and advanced CP may include pancreatic atrophy, duct distortion and strictures and calcifications’ [2]. These pancreatic morphological abnormalities (PMA) are identifiable on computed tomography (CT) which is recommended when CP is suspected [3]. (Source: Pancreatology)
Source: Pancreatology - July 6, 2018 Category: Gastroenterology Authors: Jennifer A. Campbell, JamesN.S. Hampton, Matthias L öhr, Chris Howard, David S. Sanders, Andrew D. Hopper Source Type: research
CA 19 –9 predicts resectability of pancreatic cancer even in jaundiced patients
Surgical resection remains the only curative option for pancreatic adenocarcinoma. Despite recent improvements in medical imaging, unresectability is still often discovered at the time of surgery. It is essential to identify unresectable patients preoperatively to avoid unnecessary surgery. High serum CA 19-9 levels have been suggested as a marker of unresectability but considered inaccurate in patients with hyperbilirubinemia. (Source: Pancreatology)
Source: Pancreatology - July 3, 2018 Category: Gastroenterology Authors: Nicolas Santucci, Olivier Facy, Pablo Ortega-Deballon, Jean-Baptiste Lequeu, Paul Rat, Patrick Rat Source Type: research
The adenosine, adrenergic and opioid pathways in the regulation of insulin secretion, beta cell proliferation and regeneration
Insulin, a key hormone produced by pancreatic beta cells precisely regulates glucose metabolism in vertebrates. In type 1 diabetes, the beta cell mass is destroyed, a process triggered by a combination of environmental and genetic factors. This ultimately results in absolute insulin deficiency and dysregulated glucose metabolism resulting in a number of detrimental pathophysiological effects. The traditional focus of treating type 1 diabetes has been to control blood sugar levels through the administration of exogenous insulin. (Source: Pancreatology)
Source: Pancreatology - June 20, 2018 Category: Gastroenterology Authors: Amitoj Singh, Yann Gibert, Karen M. Dwyer Tags: Review Article Source Type: research
