An in vitro system to evaluate potential therapeutic substances for ER stress reduction during pancreatitis

Objectives The acinar cells of the pancreas are highly efficient protein synthesis units that produce large amounts of secretory enzymes. Disturbances in normal function of the endoplasmic reticulum (ER) activate an evolutionarily conserved cell stress response. The unfolded protein response (UPR), is aimed at preventing cellular damage and was found to be activated also during pancreatitis. One crucial signal pathway induces through Inositol-requiring kinase 1 (IRE-1) an alternative splicing of XBP-1 mRNA which results in generation of the XBP-1s isoform, a transcription factor which helps to adapt the folding capacity of the ER after UPR induction.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Jana Marielle Modenbach, Frank Ulrich Weiss, Manuel Gronbach, Christina Oppermann, Firas El-Hage, Jola Pospech, Markus M. Lerch, Matthias Sendler Tags: 3. Experimental Pancreatitis I Source Type: research