Genetic inhibition of cyclophilin D protects against bile acid or ethanol and fatty acid induced pancreatic ductal epithelial cell damage in mice

Objectives Mitochondrial dysfunction is a hallmark of several disease pathogenesis including acute pancreatitis (AP). Our previous results suggest that mitochondrial damage is crucial in bile acid induced inhibition of pancreatic ductal HCO3- secretion, however the details of mitochondrial function and dysfunction in pancreatic ductal epithalial cells (PDEC) is not known yet. Cyclophilin D (Cyp D) has a crucial role in the opening of the mitochondrial transition pore (mPTP) which could be a target to avoid mitochondrial Ca2 + overload and cell death .

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Emese T óth, József Maléth, Réka Erdős, Noémi Závogyán, László Tretter, Gergő Horváth, Zoltán Rakonczay, Péter Hegyi Tags: 3. Experimental Pancreatitis I Source Type: research