Secreted cyclophilin A levels elevate in animal models and patients with acute pancreatitis at disease early stage

Objectives Cyclophilin A (CypA) is widely expressed and significantly increased in the pancreas of a taurocholate-induced experimental acute pancreatitis (EAP) in rats. Recombinant CypA acerbates cholecystokinin-induced acinar cell injury. However, the secreted CypA (sCypA) levels has never been determined in EAP and human AP (HAP). Our objectives are to determine the concentration of circulating sCypA in EAP and HAP, as well as its correlation with disease severity.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Wenhao Cai, Priyanka Bhattacharya, Yongjian Wen, Na Shi, Tingting Liu, Wei Huang, Qing Xia, Rajarshi Mukherjee, Robert Sutton Tags: 3. Experimental Pancreatitis I Source Type: research