Pink1-Parkin mediated mitophagy in acute pancreatitis

Objectives Acute pancreatitis (AP) is characterized by premature activation of digestive proteases within the pancreas, resulting in cell death. Previously it has been reported that mitochondrial dysfunction and impaired autophagy contribute to the pathogenesis of AP. Except for their main role in energy production, mitochondria have also been implicated in fundamental cellular processes such as ion homeostasis, lipid metabolism, and the initiation of apoptotic cell death. However, the inter-relationship between mitochondrial dysfunction and cell death in acute pancreatitis remains elusive.We investigated the role of Pink1 and the E3-ubiquitin-ligase PARK2 (Parkin) in regulating mitophagy and cell death during AP.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Preshit Ravindra Wagh, Matthias Sendler, Ujjwal Mukund Mahajan, Danniel Jhon, Frank Ulrich Weiss, Markus M. Lerch, Julia Mayerle Tags: 3. Experimental Pancreatitis I Source Type: research