Heat shock protein-90 in acute severe pancreatitis: Potential risk- defining marker

Objectives Acute severe pancreatitis can lead to pancreatic necrosis, acute lung injury, SIRS and MODS. The inducible heat shock protein-90 (HSP-90) is anti-oxidative, anti-inflammatory, and cytoproductive enzyme that is induced in response to cellular stress. In acute severe pancreatitis the membrane damage of acinar cells, acting in adherence with induced heat-shock proteins (HSPs), potentially activates and releases potent hydrolytic enzymes that can cause cell membrane damage and systemic responses.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Aiste Gulla, Rima Budvytyte, Tadas Ragaliauskas, Julija Razumiene, Kestutis Strupas Tags: 3. Experimental Pancreatitis I Source Type: research