Kynurenic acid and its novel analogue SZR-72 ameliorate experimental acute necrotizing pancreatitis in rats via NMDA-1 receptor

Objectives Background: The pathogenesis of acute pancreatitis (AP) is not well understood, the disease has no specific therapy. L-kynurenic acid (KYNA) and its analogue SZR-72 have immune modulatory roles in several inflammatory diseases. Furthermore, KYNA and SZR-72 function as antagonists of endogenous glutamate N-methyl-d-aspartate (NMDA) receptors. Aim: We investigated the effects of KYNA and SZR-72 on NMDA receptors in experimental AP.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Zsolt Balla, Bal ázs Kui, Eszter Sára Kormányos, Emese Réka Bálint, Lóránd Kiss, Béla Iványi, László Vécsei, Ferenc Fülöp, András Harazin, Mária A. Deli, Viktória Venglovecz, Tamara Madácsy, József Maléth, Péter Hegyi, Zoltan Rakoncza Tags: 3. Experimental Pancreatitis I Source Type: research