The effect of CFTR Cl- channel in the exocrine/endocrine pancreas under pathological conditions

Objectives The exocrine and endocrine part of the pancreas work in close interaction with each other in which the CFTR Cl- channel plays an essential role by regulating the secretory processes. The role of the channel under certain pathological conditions is not completely known, therefore our aim in this study was to investigate the exocrine and endocrine functions in diabetic and/or pancreatitis-induced mice in wild-type (WT) and CFTR knock out (KO) animals.
Source: Pancreatology - Category: Gastroenterology Authors: Tags: 3. Experimental Pancreatitis I Source Type: research