Regulation of transcription factors in the ER stress recognition system during acute pancreatits

Objectives The pancreas is characterized by one of the highest protein synthesis rates in the human body. Secretory enzymes are expressed at very high transcription levels. Therefore a strict regulated protein homeostasis is necessary to prevent ER-stress. Three mayor pathways are involved in unfolded protein response (UPR) to prevent ER-stress. Here we investigated the regulation of transcription factors during acute pancreatitis.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Robert Bolsmann, Frank Ulrich Weiss, Julia Mayerle, Markus M. Lerch, Matthias Sendler Tags: 3. Experimental Pancreatitis I Source Type: research