IRAK-M regulates the local and systemic immune responses in acute pancreatitis

Objectives Acute pancreatitis is characterized by premature intracellular activation of digestive enzymes which leads to self-destruction of the pancreas and a successive systemic inflammatory response. Toll-like receptors (TLRs) are innate immune sensing components which recognize damage-associated molecular patterns (DAMPs) in the injured pancreas. They activate the NF- κB pathway by myeloid differentiation primary response gene 88 (MyD88) and the phosphorylation of IL-1 receptor-associated kinases (IRAKs).

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Franziska Gisela Thiel, Frank Ullrich Weiss, Markus M. Lerch, Matthias Sendler Tags: 3. Experimental Pancreatitis I Source Type: research