Characterization of the function of transient receptor potential melastatin 2 in mouse pancreatic acinar cells

Objectives Ca2+ signaling is the hallmark of acute pancreatitis (AP) inducing mitochondrial damage, intra-acinar digestive enzyme activation and cell death. Thus prevention of toxic cellular Ca2+ overload is a promising therapeutic target. The transient receptor potential melastatin 2 (TRPM2) is a non-selective cation channel that plays major role in oxidative stress induced cellular Ca2+ overload in different cell types and also how it effects different ways of cell death. Although likely, its role in pancreatic acinar cells and the pathogenesis of AP was not investigated yet.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Julia Fanczal, Csaba P éter Biró, Tamara Madácsy, Zoltán Rakonczay, Péter Hegyi, József Maléth Tags: 3. Experimental Pancreatitis I Source Type: research