Wild‐type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma
This study explored the possible molecular mechanism of some ESCC cells insensitive to rapamycin and provided a measure for treating ESCC patients with PTEN inactivation using mTOR inhibitors. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - January 3, 2016 Category: Gastroenterology Authors: Z. Lu, J. Wang, Y. Zheng, S. Yang, M. Liu, X. Chen, C. Wang, G. Hou Tags: Original Article Source Type: research
Phase I/II study of divided‐dose docetaxel, cisplatin and fluorouracil for patients with recurrent or metastatic squamous cell carcinoma of the esophagus
This study adopted divided doses of docetaxel and CDDP in order to reduce the toxicities of the treatment. The dose of docetaxel was escalated using the following protocol in the phase I stage: level 1, 30 mg/m2; level 2, 35 mg/m2 and level 3, 40 mg/m2, which was intravenously infused for 2 hours on days 1 and 8. CDDP was administered at a dose of 12 mg/m2 infused for 4 hours on days 1–5. The 5‐FU was administered at a dose of 600 mg/m2 continuously infused from day 1 to 5. This regimen was repeated every 4 weeks. The study subjects were nine patients (phase I) and 48 patients (phase II). The recommended dose was...
Source: Diseases of the Esophagus - January 3, 2016 Category: Gastroenterology Authors: T. Ojima, M. Nakamori, M. Nakamura, M. Katsuda, K. Hayata, S. Matsumura, M. Iwahashi, H. Yamaue Tags: Original Article Source Type: research
Simple preoperative risk scale accurately predicts perioperative mortality following esophagectomy for malignancy
Summary
Surgery remains one of the major treatment options available to patients with esophageal cancer, with high mortality in certain cohorts. The aim of this study was to develop a simple preoperative risk scale based on patient factors, hospital factors, and tumor pathology to predict the risk of perioperative mortality following esophagectomy for malignancy. The Nationwide Inpatient Sample database was used to create the risk scale. Patients who underwent open or laparoscopic transhiatal and transthoracic esophageal resection were identified using International Classification of Diseases, 9th edition codes. Patients &...
Source: Diseases of the Esophagus - January 3, 2016 Category: Gastroenterology Authors: H. F. Fuchs, C. R. Harnsberger, R. C. Broderick, D. C. Chang, B. J. Sandler, G. R. Jacobsen, M. Bouvet, S. Horgan Tags: Original Article Source Type: research
Wild ‐type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma
This study explored the possible molecular mechanism of some ESCC cells insensitive to rapamycin and provided a measure for treating ESCC patients with PTEN inactivation using mTOR inhibitors. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - January 2, 2016 Category: Gastroenterology Authors: Z. Lu, J. Wang, Y. Zheng, S. Yang, M. Liu, X. Chen, C. Wang, G. Hou Tags: Original Article Source Type: research
Phase I/II study of divided ‐dose docetaxel, cisplatin and fluorouracil for patients with recurrent or metastatic squamous cell carcinoma of the esophagus
This study adopted divided doses of docetaxel and CDDP in order to reduce the toxicities of the treatment. The dose of docetaxel was escalated using the following protocol in the phase I stage: level 1, 30 mg/m2; level 2, 35 mg/m2 and level 3, 40 mg/m2, which was intravenously infused for 2 hours on days 1 and 8. CDDP was administered at a dose of 12 mg/m2 infused for 4 hours on days 1–5. The 5‐FU was administered at a dose of 600 mg/m2 continuously infused from day 1 to 5. This regimen was repeated every 4 weeks. The study subjects were nine patients (phase I) and 48 patients (phase II). The recommended dose was...
Source: Diseases of the Esophagus - January 2, 2016 Category: Gastroenterology Authors: T. Ojima, M. Nakamori, M. Nakamura, M. Katsuda, K. Hayata, S. Matsumura, M. Iwahashi, H. Yamaue Tags: Original Article Source Type: research
Concurrent chemoradiotherapy with elective lymph node irradiation for esophageal cancer: a systemic review and pooled analysis of the literature
In conclusion, ENI is feasible with acceptable toxicities in esophageal carcinoma and the efficacy should be verified in randomized trials. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - January 1, 2016 Category: Gastroenterology Authors: Dexi Du, Tao Song, Xiaodong Liang, Min Fang, Shixiu Wu Tags: Review Article Source Type: research
Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring
Summary
Eosinophilic esophagitis (EoE) is diagnosed by symptoms, and at least 15 intraepithelial eosinophils per high power field in an esophageal biopsy. Other pathologic features have not been emphasized. We developed a histology scoring system for esophageal biopsies that evaluates eight features: eosinophil density, basal zone hyperplasia, eosinophil abscesses, eosinophil surface layering, dilated intercellular spaces (DIS), surface epithelial alteration, dyskeratotic epithelial cells, and lamina propria fibrosis. Severity (grade) and extent (stage) of abnormalities were scored using a 4‐point scale (0 normal; 3 maxi...
Source: Diseases of the Esophagus - January 1, 2016 Category: Gastroenterology Authors: M. H. Collins, L. J. Martin, E. S. Alexander, J. Todd Boyd, R. Sheridan, H. He, S. Pentiuk, P. E. Putnam, J. P. Abonia, V. A. Mukkada, J. P. Franciosi, M. E. Rothenberg Tags: Original Article Source Type: research
Long noncoding RNA, tissue differentiation‐inducing nonprotein coding RNA is upregulated and promotes development of esophageal squamous cell carcinoma
Summary
Esophageal squamous cell carcinoma (ESCC) is one of the major causes of cancer death worldwide, especially in Eastern Asia. Due to the poor prognosis, it is necessary to further dissect the underlying mechanisms and explore therapeutic targets of ESCC. Recently, studies show that long noncoding RNAs (lncRNAs) have critical roles in diverse biological processes, including tumorigenesis. Increasing evidence indicates that some lncRNAs are widely involved in the development and progression of ESCC, such as HOTAIR, SPRY4‐IT1 and POU3F3. An emerging lncRNA, tissue differentiation‐inducing nonprotein coding RNA (TINC...
Source: Diseases of the Esophagus - January 1, 2016 Category: Gastroenterology Authors: Y. Xu, M. Qiu, Y. Chen, J. Wang, W. Xia, Q. Mao, L. Yang, M. Li, F. Jiang, L. Xu, R. Yin Tags: Original Article Source Type: research
Simultaneous thoraco‐laparoscopic repair of giant hiatal hernias: an alternative approach
Summary
Laparoscopic repair of giant hiatal hernias with intrathoracic displacement of organs is recommended to relieve troublesome symptoms in patients. During this procedure, incomplete excision of the hernia sac from the mediastinum and omission of creating a ‘non‐tension‐free position’ of the cardio‐esophageal junction into the abdominal cavity are associated with hiatal hernia recurrence. Giant hiatal hernias therefore often require a thoracotomy or thoracoscopy, to free dense adhesions higher up the chest. These procedures may increase the risk of perioperative morbidity due to lengthy operating times. We d...
Source: Diseases of the Esophagus - January 1, 2016 Category: Gastroenterology Authors: W. J. Derksen, J. E. Oor, A. Yilmaz, E. J. Hazebroek Tags: Original Article Source Type: research
Laparoscopic alternatives to fundoplication for gastroesophageal reflux: the role of magnetic augmentation and electrical stimulation of the lower esophageal sphincter
Diseases of the Esophagus,Volume 29, Issue 8, Page 996-1001, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - December 17, 2015 Category: Gastroenterology Source Type: research
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Diseases of the Esophagus,Volume 29, Issue 8, Page 996-1001, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - December 17, 2015 Category: Gastroenterology Source Type: research
Reduced toxicity with three ‐dimensional conformal radiotherapy or intensity‐modulated radiotherapy compared with conventional two‐dimensional radiotherapy for esophageal squamous cell carcinoma: a secondary analysis of data from four prospective clinical trials
Diseases of the Esophagus,Volume 29, Issue 8, Page 1121-1127, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - December 10, 2015 Category: Gastroenterology Source Type: research
Adjuvant sunitinib following chemoradiotherapy and surgery for locally advanced esophageal cancer: a phase II trial
Diseases of the Esophagus,Volume 29, Issue 8, Page 1152-1158, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - December 10, 2015 Category: Gastroenterology Source Type: research
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Diseases of the Esophagus,Volume 29, Issue 8, Page 1121-1127, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - December 10, 2015 Category: Gastroenterology Source Type: research
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Diseases of the Esophagus,Volume 29, Issue 8, Page 1152-1158, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - December 10, 2015 Category: Gastroenterology Source Type: research
