Novel methylene blue staining technique for localizing small esophageal leiomyomas during thoracoscopic enucleation
SummaryThe treatment of choice for leiomyoma, the most common benign esophageal tumor, is thoracoscopic enucleation. One of the most difficult aspects of thoracoscopic enucleation is the precise localization of small tumors (≤1.5 cm) and tumors without external protrusion. No simple, feasible solutions to this problem are available. We developed a novel methylene blue staining technique to localize small esophageal leiomyomas and evaluated the feasibility of our technique. Between January 2013 and July 2014, eight patients with small esophageal leiomyomas (≤1.5 cm) underwent thoracoscopic enucleation in Tongji Hosp...
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Authors: Z. Zhang, B. Ai, Y. Liao, L. Liu, M. Liu Tags: Original Article Source Type: research
Esophageal submucosal gland duct adenoma: a clinicopathological and immunohistochemical study with a review of the literature
In this study, we aimed at delineating the clinicopathological features of the ESGDA and cyst formation of the esophageal submucosal gland duct (ESGD), as well as their correlations and clinical implications. We identified three cases of ESGDA and 16 cases of cyst formation of the ESGD among 786 endoscopic mucosal resection specimens over a 7‐year period. The median patient age was 58 years with a male predominance. These lesions were small submucosal bulges locating at the lower esophagus with a size no more than 1 cm. The main microscopic changes of these lesions included content retention, multilayered epithelium or...
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Authors: L. Nie, H. Y. Wu, Y. H. Shen, X. S. Fan, Q. Sun, Q. Huang, J. Chen Tags: Original Article Source Type: research
Effect of baclofen on gastric acid pocket in subjects with gastroesophageal reflux disease symptoms
Summary
Postprandial gastroesophageal reflux (PGER) in the distal esophagus (DE) is associated with a gastric juice ‘acid pocket’ (AP). Baclofen reduces AP extension into the DE in healthy volunteers, in part through increased lower esophageal sphincter (LES) pressure. We aimed to verify whether baclofen also affects postprandial AP location and extent in gastroesophageal reflux disease (GERD) patients. Thirteen treatment‐naive heartburn‐prevalent GERD patients underwent two AP studies, after pretreatment with baclofen 40 mg or placebo 30 minutes preprandially. We performed pH‐probe stepwise pull‐throughs (...
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Authors: E. Scarpellini, V. Boecxstaens, C. Broers, R. Vos, A. Pauwels, J Tack Tags: Original Article Source Type: research
Co ‐occurrence of eosinophilic esophagitis and potential/probable celiac disease in an adult cohort: a possible association with implications for clinical practice
We describe an adult cohort with eosinophilic esophagitis (EoE) and evidence of celiac disease (CD), propose a change in diagnostic practice to better characterize these conditions, and hypothesize new directions for research. Pediatric studies postulate association between gluten sensitivity and EoE. However, few publications describe the prevalence, detection, or therapeutic and pathophysiologic implications of such association in adults. Retrospective chart review was done on patients diagnosed with EoE from 2009 to 2010 at University of Utah Hospitals and Clinics. Data included sex, age, presentation, duodenal patholog...
Source: Diseases of the Esophagus - November 5, 2015 Category: Gastroenterology Authors: J. B. Johnson, K. K. Boynton, K. A. Peterson Tags: Benign Esophageal Disease Source Type: research
Survival outcomes of 220 consecutive patients with three ‐staged thoracoscopic esophagectomy
Summary
Patients with thoracic esophageal cancer are often treated by minimally invasive esophagectomy. However, the long‐term survival benefits of minimally invasive esophagectomy remain unclear. Two approaches are available for thoracoscopic surgery: one with the patient in the left lateral decubitus position (LLDP), and the other with the patient in the prone position (PP). We investigated the survival benefit of thoracoscopic esophagectomy according to the tumor stage and patient position during the thoracoscopic procedure. We reviewed the records of 220 consecutive patients with esophageal cancer treated from 1998 t...
Source: Diseases of the Esophagus - November 5, 2015 Category: Gastroenterology Authors: H. Noshiro, Y. Yoda, M. Hiraki, H. Kono, S. Miyake, A. Uchiyama, E. Nagai Tags: Original Article Source Type: research
Association of genetic polymorphisms in PTEN and additional gene –gene interaction with risk of esophageal squamous cell carcinoma in Chinese Han population
This study aims to investigate the association of five single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homologue (PTEN) gene and additional role of gene–gene interaction with esophageal squamous cell carcinoma (ESCC), based on a Chinese case–control study. A total of 871 subjects (420 males and 451 females) were selected, including 425 ESCC cases and 446 controls. Five SNPs were selected for genotyping in the case–control study: rs2735343, rs555895, rs2299939, rs17431184 and rs701848. Logistic regression model was used to examine the association between five SNP and ESCC, and additional interacti...
Source: Diseases of the Esophagus - November 5, 2015 Category: Gastroenterology Authors: X. Xu, G. Chen, L. Wu, L. Liu Tags: Original Article Source Type: research
Biobanking of fresh ‐frozen endoscopic biopsy specimens from esophageal adenocarcinoma
Summary
The process of preparing endoscopic esophageal adenocarcinoma samples for next‐generation DNA/RNA sequencing is poorly described. Therefore, we assessed the feasibility and pitfalls of preparing esophageal adenocarcinoma endoscopic biopsies toward DNA/RNA samples suitable for next‐generation sequencing. In this prospective study, four tumor biopsy samples were collected from consecutive esophageal cancer patients during esophagogastroduodenoscopy and fresh‐frozen in liquid nitrogen. DNA and RNA were isolated from samples with a tumor percentage of at least 50%. For next‐generation sequencing, double‐stran...
Source: Diseases of the Esophagus - November 5, 2015 Category: Gastroenterology Authors: J. Stiekema, A. Cats, H. Boot, A. M. J. Langers, O. Balague Ponz, M. L. F. Velthuysen, L. M. Braaf, M. Nieuwland, J. W. Sandick Tags: Original Article Source Type: research
Intra ‐bolus pressure and esophagogastric gradient, assessed with high‐resolution manometry, are associated with acid exposure and proximal migration of refluxate
Summary
Trans‐sphincteric pressure gradient (TSPG) seems to play a relevant role in eliciting refluxes during transient lower esophageal sphincter relaxations (TLESRs). Intra‐bolus pressure (IBP) is considered to be correlated to esophageal wall tone. We aimed to evaluate the relationship between IBP, TSPG during TLESRs and the dynamic properties of refluxate in gastroesophageal reflux disease. Sixteen non‐erosive reflux disease (NERD), 10 erosive disease (ERD) patients and 12 healthy volunteers (HVs), underwent 24‐hour impedance‐pH monitoring and combined high‐resolution manometry‐impedance before and 60 min...
Source: Diseases of the Esophagus - November 5, 2015 Category: Gastroenterology Authors: M. Ribolsi, P. Balestrieri, R. H Holloway, S. Emerenziani, M. Cicala Tags: Original Article Source Type: research
Heller's myotomy and pneumatic dilatation in the treatment of achalasia: a population ‐based case–control study assessing long‐term quality of life
SummaryLong‐term health‐related quality‐of‐life (HRQL) outcomes have not been widely reported in the treatment of achalasia. The aims of this study were to examine long‐term disease‐specific and general HRQL in achalasia patients using a population‐based case–control method, and to assess HRQL between treatment interventions. Manometrically diagnosed achalasia cases (n = 120) were identified and matched with controls (n = 115) using a population‐based approach. Participants completed general (SF‐12) and disease‐specific (Achalasia Severity Questionnaire [ASQ]) HRQL questionnaires, as appropriate, in a...
Source: Diseases of the Esophagus - November 5, 2015 Category: Gastroenterology Authors: R. T. Gray, H. G. Coleman, K. W. Lau, C. McCaughey, P. V. Coyle, L. J. Murray, B. T. Johnston Tags: Original Article Source Type: research
Role of definitive chemoradiotherapy using docetaxel and 5 ‐fluorouracil in patients with unresectable locally advanced esophageal squamous cell carcinoma: a phase II study
Diseases of the Esophagus,Volume 29, Issue 8, Page 1115-1120, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - October 15, 2015 Category: Gastroenterology Source Type: research
Changes in symptom reflux association using dynamic pH thresholds during ambulatory pH monitoring: an observational cross ‐sectional study
Diseases of the Esophagus,Volume 29, Issue 8, Page 1013-1019, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - October 15, 2015 Category: Gastroenterology Source Type: research
Evaluation of the Glasgow Prognostic Score in patients receiving chemoradiotherapy for stage III and IV esophageal cancer
Diseases of the Esophagus,Volume 29, Issue 8, Page 1071-1080, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - October 15, 2015 Category: Gastroenterology Source Type: research
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Diseases of the Esophagus,Volume 29, Issue 8, Page 1115-1120, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - October 15, 2015 Category: Gastroenterology Source Type: research
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Diseases of the Esophagus,Volume 29, Issue 8, Page 1013-1019, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - October 15, 2015 Category: Gastroenterology Source Type: research
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Diseases of the Esophagus,Volume 29, Issue 8, Page 1071-1080, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - October 15, 2015 Category: Gastroenterology Source Type: research
