Routine endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma: a prospective study
Summary
Early detection of synchronous esophageal squamous cell neoplasm (ESCN) in head and neck squamous cell carcinoma (HNSCC) patients can significantly affect their prognosis. We investigated the prevalence of synchronous ESCN and the risk factors for developing ESCN in patients with HNSCC, and evaluated the effect of routine endoscopic screening in these patients. Subjects who were diagnosed as HNSCC from May 2010 to January 2014 were eligible. All patients underwent conventional white light endoscopic examinations with narrow band imaging and Lugol chromoendoscopy. Among 458 subjects screened, 28 synchronous ESCN wer...
Source: Diseases of the Esophagus - October 15, 2015 Category: Gastroenterology Authors: E. J. Gong, D. H. Kim, J. Y. Ahn, K.‐S. Choi, K. W. Jung, J. H. Lee, K. D. Choi, H. J. Song, G. H. Lee, H.‐Y. Jung, J. H. Kim, J.‐L. Roh, S.‐H. Choi, S. Y. Nam, S. Y. Kim Tags: Original article Source Type: research
Systematic review of patient‐reported outcome measures in the surgical treatment of patients with esophageal cancer
Summary
Esophageal cancer is currently the eighth most common cancer worldwide. Improvements in operative techniques and neoadjuvant therapies have led to improved outcomes. Resection of the esophagus carries a high risk of severe complications and has a negative impact on health‐related quality of life (QOL). The aim of this study was to assess which patient‐reported outcome measures (PROMs) are used to measure QOL after esophagectomy for cancer. A comprehensive search of original articles was conducted investigating QOL after surgery for esophageal carcinoma. Two authors independently selected relevant articles, cond...
Source: Diseases of the Esophagus - October 15, 2015 Category: Gastroenterology Authors: J. Straatman, P. J. M. Joosten, C. B. Terwee, M. A. Cuesta, E. P. Jansma, D. L. Peet Tags: Review article Source Type: research
Evaluation of the Glasgow Prognostic Score in patients receiving chemoradiotherapy for stage III and IV esophageal cancer
Summary
High Glasgow Prognostic scores (GPSs) have been associated with poor outcomes in various tumors, but the values of GPS and modified GPS (mGPS) in patients with advanced esophageal cancer receiving chemoradiotherapy (CRT) has not yet been reported. We have evaluated these with respect to predicting responsiveness to CRT and long‐term survival. Between January 2002 and December 2011, tumor responses in 142 esophageal cancer patients (131 men and 11 women) with stage III (A, B and C) and IV receiving CRT were assessed. We assessed the value of the GPS as a predictor of a response to definitive CRT and also as a prog...
Source: Diseases of the Esophagus - October 15, 2015 Category: Gastroenterology Authors: J. Kimura, C. Kunisaki, H. Makino, T. Oshima, M. Ota, M. Oba, R. Takagawa, T. Kosaka, H. A. Ono, H. Akiyama, I. Endo Tags: Original article Source Type: research
Changes in symptom reflux association using dynamic pH thresholds during ambulatory pH monitoring: an observational cross‐sectional study
Summary
Symptom reflux association (SRA) assesses symptoms associated with reflux events defined by pH <4.0, but limited symptoms associate with reflux events. We evaluated the impact of alternate pH thresholds on SRA in a large ambulatory pH database. Acid exposure time (AET), reflux events, and associated symptoms (within 2 minutes following a reflux event) were extracted from ambulatory pH studies performed off antireflux therapy (722 patients, 49.1 ± 0.5 years, 66.8% F) over a 7‐year period. Symptom association probability (SAP) and symptom index (SI) were calculated at pH 3.5, 4.0, 4.5, and 5. Receiver operating...
Source: Diseases of the Esophagus - October 15, 2015 Category: Gastroenterology Authors: S. Gaddam, A. Sathyamurthy, V. Kushnir, J. Drapekin, G. Sayuk, C. P. Gyawali Tags: Original article Source Type: research
Role of definitive chemoradiotherapy using docetaxel and 5 ‐fluorouracil in patients with unresectable locally advanced esophageal squamous cell carcinoma: a phase II study
Summary
Definitive chemoradiotherapy (CRT) with docetaxel (DOC) and 5‐fluorouracil (5‐FU) is a unique regimen for esophageal cancer. In this prospective phase II study, antitumor effect and safety of CRT using DOC and 5‐FU for inoperable locally advanced esophageal cancer were evaluated. DOC 7.5 mg/m2 was infused on days 1, 8, 22, and 29. 5‐FU 250 mg/m2/day was infused continuously on days 1–5, 8–12, 15–19, 22–26, 29–33, 36–40, and 43–45. Radiotherapy was given to 66 Gy in 33 fractions. Eleven patients with thoracic and five with cervical esophageal cancer were eligible. All patients had esophag...
Source: Diseases of the Esophagus - October 14, 2015 Category: Gastroenterology Authors: J. Hihara, Y. Hamai, M. Emi, Y. Murakami, M. Kenjo, Y. Nagata, M. Okada Tags: Malignant Esophageal Disease Source Type: research
Systematic review of patient ‐reported outcome measures in the surgical treatment of patients with esophageal cancer
Summary
Esophageal cancer is currently the eighth most common cancer worldwide. Improvements in operative techniques and neoadjuvant therapies have led to improved outcomes. Resection of the esophagus carries a high risk of severe complications and has a negative impact on health‐related quality of life (QOL). The aim of this study was to assess which patient‐reported outcome measures (PROMs) are used to measure QOL after esophagectomy for cancer. A comprehensive search of original articles was conducted investigating QOL after surgery for esophageal carcinoma. Two authors independently selected relevant articles, cond...
Source: Diseases of the Esophagus - October 14, 2015 Category: Gastroenterology Authors: J. Straatman, P. J. M. Joosten, C. B. Terwee, M. A. Cuesta, E. P. Jansma, D. L. Peet Tags: Malignant Esophageal Disease Source Type: research
Helicobacter pylori infection and gastroesophageal reflux in children
Diseases of the Esophagus,Volume 29, Issue 8, Page 1007-1012, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - October 12, 2015 Category: Gastroenterology Source Type: research
Genotypes of CYP1A1, SULT1A1 and SULT1A2 and risk of squamous cell carcinoma of esophagus: outcome of a case–control study from Kashmir, India
Diseases of the Esophagus,Volume 29, Issue 8, Page 937-943, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - October 12, 2015 Category: Gastroenterology Source Type: research
Toward improved survivorship: supportive care needs of esophageal cancer patients, a literature review
Diseases of the Esophagus,Volume 29, Issue 8, Page 1081-1089, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - October 12, 2015 Category: Gastroenterology Source Type: research
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Diseases of the Esophagus,Volume 29, Issue 8, Page 1007-1012, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - October 12, 2015 Category: Gastroenterology Source Type: research
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Diseases of the Esophagus,Volume 29, Issue 8, Page 937-943, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - October 12, 2015 Category: Gastroenterology Source Type: research
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Diseases of the Esophagus,Volume 29, Issue 8, Page 1081-1089, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - October 12, 2015 Category: Gastroenterology Source Type: research
Issue Information
(Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - October 12, 2015 Category: Gastroenterology Tags: Issue Information Source Type: research
Association between diabetes and esophageal cancer, independent of obesity, in the United States Veterans Affairs population
SummaryIn the past 30 years, the incidence of esophageal adenocarcinoma (EAC) has increased more rapidly than any other cancer in the United States. The prevalence of obesity and diabetes mellitus has drastically increased as well. We explored the potential association between obesity, diabetes mellitus, and EAC. By means of retrospective interrogation of an administrative database from fiscal year 2005–2009, we identified two cohorts. The cancer cohort was defined as patients with adenocarcinoma of the distal esophagus or gastric cardia. The comparison cohort contained patients with gastroesophageal reflux disorder (GER...
Source: Diseases of the Esophagus - October 12, 2015 Category: Gastroenterology Authors: J. L. Dixon, L. A. Copeland, J. E. Zeber, A. A. MacCarthy, S. I. Reznik, W. R. Smythe, P. A. Rascoe Tags: Original article Source Type: research
Genotypes of CYP1A1, SULT1A1 and SULT1A2 and risk of squamous cell carcinoma of esophagus: outcome of a case–control study from Kashmir, India
Summary
Studies on associations of various polymorphism in xenobiotic metabolizing genes with different cancers including esophageal squamous cell carcinoma (ESCC) are mixed and inconclusive. To evaluate the association of CYP1A1*4, SULT1A1*2 and SULT1A2*2 genotypes with ESCC risk and their modifying effects on different risk factors of ESCC, we conducted a case–control study in Kashmir, India, an area with relative high incidence of ESCC. We recruited 404 histopathologically confirmed ESCC cases, and equal number of controls, individually matched for sex, age and district of residence to respective case. Information w...
Source: Diseases of the Esophagus - October 12, 2015 Category: Gastroenterology Authors: I. A. Shah, G. A. Bhat, P. Mehta, M. M. Lone, N. A. Dar Tags: Original article Source Type: research
