Hydrogen sulfide synthesis enzymes reduced in lower esophageal sphincter of patients with achalasia
In conclusion, the expression of hydrogen sulfide synthesis enzymes, cystathionine‐β‐synthase and cystathionine‐γ‐lyase, can be detected in human esophagus and is reduced in patients with achalasia, which implicates the involvement of the two hydrogen sulfide synthesis enzymes in the pathophysiology of achalasia. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - August 28, 2015 Category: Gastroenterology Authors: L. Zhang, W. Zhao, Z. Zheng, T. Wang, C. Zhao, G. Zhou, H. Jin, B. Wang Tags: Original Article Source Type: research
Systematic review and meta‐analysis on the significance of salvage esophagectomy for persistent or recurrent esophageal squamous cell carcinoma after definitive chemoradiotherapy
Summary
The therapeutic strategy to be recommended in case of recurrent or persistent squamous cell esophageal cancer after completed definitive chemoradiotherapy (dCRT) has to be documented. Salvage esophagectomy has traditionally been recognized as a viable option, but many clinicians oppose the use of surgery due to the associated excessive morbidity and mortality. ‘Second‐line’ chemoradiotherapy (CRT) without surgery may offer a treatment alternative in these difficult and demanding clinical situations. Until now, no comprehensive attempt has been carried out to compare the respective therapeutic options. A syste...
Source: Diseases of the Esophagus - August 28, 2015 Category: Gastroenterology Authors: K. Kumagai, D. Mariosa, J. A. Tsai, M. Nilsson, W. Ye, L. Lundell, I. Rouvelas Tags: Review Article Source Type: research
Endoscopic resection of a giant esophageal lipoma: a case report
(Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - August 28, 2015 Category: Gastroenterology Authors: Xiaojun Zhao, Xin Wang, Aiqin Li, Jianqiu Sheng Tags: Images in Esophageal Diseases Source Type: research
Systematic review and meta ‐analysis on the significance of salvage esophagectomy for persistent or recurrent esophageal squamous cell carcinoma after definitive chemoradiotherapy
Summary
The therapeutic strategy to be recommended in case of recurrent or persistent squamous cell esophageal cancer after completed definitive chemoradiotherapy (dCRT) has to be documented. Salvage esophagectomy has traditionally been recognized as a viable option, but many clinicians oppose the use of surgery due to the associated excessive morbidity and mortality. ‘Second‐line’ chemoradiotherapy (CRT) without surgery may offer a treatment alternative in these difficult and demanding clinical situations. Until now, no comprehensive attempt has been carried out to compare the respective therapeutic options. A syste...
Source: Diseases of the Esophagus - August 27, 2015 Category: Gastroenterology Authors: K. Kumagai, D. Mariosa, J. A. Tsai, M. Nilsson, W. Ye, L. Lundell, I. Rouvelas Tags: Malignant Esophageal Disease Source Type: research
Circumferential cryoablation in a strictured esophagus: a feasibility and dose ‐finding study in a porcine model after inducing stenosis by endoscopic mucosal resection
SummaryIn the treatment of early esophageal Barrett's neoplasia, radiofrequency ablation may be hindered by stenosis due to prior endoscopic resection (ER). The flexible balloon‐based circumferential CryoBalloon Ablation System (CBAS) may overcome this problem by the conformability of the compliant balloon which might enable circumferential cryoablation in a stenosis. The aim of the current study was to evaluate the feasibility of the CBAS as well as the dose–response effect of cryoablation in a strictured esophagus model. In six pigs, a stenosis was induced by ER (3 cm in length, 75% of circumference) in the proxima...
Source: Diseases of the Esophagus - August 27, 2015 Category: Gastroenterology Authors: D. W. Sch ölvinck, J. J. G. H. M. Bergman, M. Visser, B. L. A. M. Weusten Tags: Benign Esophageal Disease Source Type: research
Squamous cell carcinoma arising from a Zenker's diverticulum: contribution of FDG‐PET/CT to the diagnosis
(Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - August 1, 2015 Category: Gastroenterology Authors: T. Acar, R. Savaş, K. Kocaçelebi, G. Ersöz Tags: Images in esophageal diseases Source Type: research
Hybrid minimally invasive esophagectomy for cancer: impact on postoperative inflammatory and nutritional status
Summary
The purpose of this case–control study was to evaluate the impact of hybrid minimally invasive esophagectomy for cancer on surgical stress response and nutritional status. All 34 consecutive patients undergoing hybrid minimally invasive esophagectomy for cancer at our surgical unit between 2008 and 2013 were retrospectively compared with 34 patients undergoing esophagectomy with open gastric tubulization (open), matched for neoadjuvant therapy, pathological stage, gender and age. Demographic data, tumor features and postoperative course (including quality of life and systemic inflammatory and nutritional status) ...
Source: Diseases of the Esophagus - August 1, 2015 Category: Gastroenterology Authors: M. Scarpa, F. Cavallin, L. M. Saadeh, E. Pinto, R. Alfieri, M. Cagol, A. Da Roit, E. Pizzolato, G. Noaro, G. Pozza, C. Castoro Tags: Original article Source Type: research
Optimal surgical approach for esophageal cancer in the era of minimally invasive esophagectomy and neoadjuvant therapy
Summary
The optimal surgical technique for the potentially curative treatment of patients with esophageal cancer is still under debate. The transhiatal esophagectomy (THE) with limited lymphadenectomy mainly focuses on a decrease of postoperative morbidity and mortality by preventing a formal thoracotomy. The transthoracic esophagectomy (TTE) with extended two‐field lymphadenectomy attempts to improve the radicality of the resection and thus to increase locoregional tumor control, but is associated with increased postoperative morbidity. The recent introduction of different minimally invasive techniques probably decrease...
Source: Diseases of the Esophagus - August 1, 2015 Category: Gastroenterology Authors: B. J. Noordman, B. P. L. Wijnhoven, J. J. B. Lanschot Tags: Review article Source Type: research
Pseudoachalasia secondary to bariatric surgery
We report four patients who years after a bariatric procedure developed dysphagia followed by esophageal body radiographic and/or manometric features of achalasia. In addition, each of these patients responded symptomatically to endoscopic or surgical therapy either which lowered this high‐pressure zone. Furthermore, review of prior cases in the literature suggests this has occurred before. Physicians should be aware of this association but further study is needed on its true prevalence. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - August 1, 2015 Category: Gastroenterology Authors: K. Ravi, S. Sweetser, D. A. Katzka Tags: Original article Source Type: research
Salvage pharyngolaryngectomy with total esophagectomy following definitive chemoradiotherapy
Summary
Historically, total pharyngolaryngectomy with total esophagectomy has been the standard radical surgical treatment for synchronous cancer of the thoracoabdominal esophagus and pharyngolaryngeal region, and for cancer of the cervical esophagus that has invaded as far as the thoracic esophagus. Although definitive chemoradiotherapy that enables preservation of the larynx has often been the first choice of treatment for cancers involving the cervical esophagus, total pharyngolaryngectomy with total esophagectomy is required as a salvage therapy for cases involving failure of complete remission or locoregional recurren...
Source: Diseases of the Esophagus - August 1, 2015 Category: Gastroenterology Authors: Y. Niwa, M. Koike, Y. Fujimoto, H. Oya, N. Iwata, N. Nishio, M. Hiramatsu, M. Kanda, D. Kobayashi, C. Tanaka, S. Yamada, T. Fujii, G. Nakayama, H. Sugimoto, S. Nomoto, M. Fujiwara, Y. Kodera Tags: Original Article Source Type: research
Prognostic significance of preoperative absolute peripheral monocyte count in esophageal squamous cell carcinoma
The objective of this study was to investigate the prognostic value of peripheral blood monocytes in esophageal squamous cell carcinoma (ESCC) patients who underwent esophagectomy. Records from 218 consecutive patients with histologically diagnosed ESCC who underwent esophagectomy at Qilu Hospital of Shandong University from January 2007 to December 2008 were retrospectively reviewed. The median disease‐free survival (DFS) of this cohort was 29.0 months, and the 5‐year DFS rate was 34.4%. The median overall survival (OS) was 35.0 months, and the 5‐year OS rate was 37.6%. The cut‐off value of 0.42 × 109/L for the a...
Source: Diseases of the Esophagus - August 1, 2015 Category: Gastroenterology Authors: L. Han, Y. Jia, Q. Song, N. Wang, J. Wang, B. Bai, X. Chen, C. Wang, Y. Cheng Tags: Original Article Source Type: research
Randomized controlled trial comparing esophageal dilation to no dilation among adults with esophageal eosinophilia and dysphagia
Diseases of the Esophagus,Volume 29, Issue 8, Page 983-991, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - July 30, 2015 Category: Gastroenterology Source Type: research
Combining different therapeutic interventions in eosinophilic esophagitis may lead to unreplicable and misleading results
Diseases of the Esophagus,Volume 29, Issue 8, Page 1172-1172, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - July 30, 2015 Category: Gastroenterology Source Type: research
Esophagogastric junctional adenocarcinoma originating from endoscopically unrecognizable Barrett's epithelium
Diseases of the Esophagus,Volume 29, Issue 8, Page 1164-1166, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - July 30, 2015 Category: Gastroenterology Source Type: research
High ‐resolution manometry findings in symptomatic post‐Nissen fundoplication patients with normal endoscopic configuration
Diseases of the Esophagus,Volume 29, Issue 8, Page 967-970, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - July 30, 2015 Category: Gastroenterology Source Type: research
