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Diseases of the Esophagus,Volume 29, Issue 8, Page 1043-1047, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Source Type: research
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Diseases of the Esophagus,Volume 29, Issue 8, Page 1144-1151, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Source Type: research
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Diseases of the Esophagus,Volume 29, Issue 8, Page 944-949, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Source Type: research
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Diseases of the Esophagus,Volume 29, Issue 8, Page 1090-1099, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Source Type: research
Co‐occurrence of eosinophilic esophagitis and potential/probable celiac disease in an adult cohort: a possible association with implications for clinical practice
We describe an adult cohort with eosinophilic esophagitis (EoE) and evidence of celiac disease (CD), propose a change in diagnostic practice to better characterize these conditions, and hypothesize new directions for research. Pediatric studies postulate association between gluten sensitivity and EoE. However, few publications describe the prevalence, detection, or therapeutic and pathophysiologic implications of such association in adults. Retrospective chart review was done on patients diagnosed with EoE from 2009 to 2010 at University of Utah Hospitals and Clinics. Data included sex, age, presentation, duodenal patholog...
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Authors: J. B. Johnson, K. K. Boynton, K. A. Peterson Tags: Original Article Source Type: research
Survival outcomes of 220 consecutive patients with three‐staged thoracoscopic esophagectomy
Summary
Patients with thoracic esophageal cancer are often treated by minimally invasive esophagectomy. However, the long‐term survival benefits of minimally invasive esophagectomy remain unclear. Two approaches are available for thoracoscopic surgery: one with the patient in the left lateral decubitus position (LLDP), and the other with the patient in the prone position (PP). We investigated the survival benefit of thoracoscopic esophagectomy according to the tumor stage and patient position during the thoracoscopic procedure. We reviewed the records of 220 consecutive patients with esophageal cancer treated from 1998 t...
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Authors: H. Noshiro, Y. Yoda, M. Hiraki, H. Kono, S. Miyake, A. Uchiyama, E. Nagai Tags: Original Article Source Type: research
Association of genetic polymorphisms in PTEN and additional gene–gene interaction with risk of esophageal squamous cell carcinoma in Chinese Han population
This study aims to investigate the association of five single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homologue (PTEN) gene and additional role of gene–gene interaction with esophageal squamous cell carcinoma (ESCC), based on a Chinese case–control study. A total of 871 subjects (420 males and 451 females) were selected, including 425 ESCC cases and 446 controls. Five SNPs were selected for genotyping in the case–control study: rs2735343, rs555895, rs2299939, rs17431184 and rs701848. Logistic regression model was used to examine the association between five SNP and ESCC, and additional interacti...
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Authors: X. Xu, G. Chen, L. Wu, L. Liu Tags: Original Article Source Type: research
Biobanking of fresh‐frozen endoscopic biopsy specimens from esophageal adenocarcinoma
Summary
The process of preparing endoscopic esophageal adenocarcinoma samples for next‐generation DNA/RNA sequencing is poorly described. Therefore, we assessed the feasibility and pitfalls of preparing esophageal adenocarcinoma endoscopic biopsies toward DNA/RNA samples suitable for next‐generation sequencing. In this prospective study, four tumor biopsy samples were collected from consecutive esophageal cancer patients during esophagogastroduodenoscopy and fresh‐frozen in liquid nitrogen. DNA and RNA were isolated from samples with a tumor percentage of at least 50%. For next‐generation sequencing, double‐stran...
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Authors: J. Stiekema, A. Cats, H. Boot, A. M. J. Langers, O. Balague Ponz, M. L. F. Velthuysen, L. M. Braaf, M. Nieuwland, J. W. Sandick Tags: Original Article Source Type: research
Comparison of environmental risk factors for esophageal atresia, anorectal malformations, and the combined phenotype in 263 German families
Summary
Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) and anorectal malformations (ARM) represent the severe ends of the fore‐ and hindgut malformation spectra. Previous research suggests that environmental factors are implicated in their etiology. These risk factors might indicate the influence of specific etiological mechanisms on distinct developmental processes (e.g. fore‐ vs. hindgut malformation). The present study compared environmental factors in patients with isolated EA/TEF, isolated ARM, and the combined phenotype during the periconceptional period and the first trimester of pregnancy...
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Authors: N. Zwink, V. Choinitzki, F. Baudisch, A. Hölscher, T. M. Boemers, S. Turial, R. Kurz, A. Heydweiller, K. Keppler, A. Müller, S. Bagci, M. Pauly, U. Brokmeier, A. Leutner, P. Degenhardt, E. Schmiedeke, S. Märzheuser, S. Grasshoff‐Derr, S. Holland‐Cu Tags: Original Article Source Type: research
Increasing the interval between neoadjuvant chemoradiotherapy and surgery in esophageal cancer: a meta‐analysis of published studies
Summary
The aim of this meta‐analysis was to clarify whether a longer interval between the end of neoadjuvant chemoradiotherapy (nCRT) and surgery is associated with better outcomes in esophageal cancer. nCRT followed by surgery is the most common approach for patients with resectable esophageal cancer. Operations are performed within 2–8 weeks after nCRT; however, the optimal interval between nCRT and surgery for esophageal cancer is unknown. We performed a systematic literature search in MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, and the Clinical Trials database for studies published between...
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Authors: G. Lin, S.‐Y. Han, Y.‐P. Xu, W.‐M. Mao Tags: Original Article Source Type: research
Intra‐bolus pressure and esophagogastric gradient, assessed with high‐resolution manometry, are associated with acid exposure and proximal migration of refluxate
Summary
Trans‐sphincteric pressure gradient (TSPG) seems to play a relevant role in eliciting refluxes during transient lower esophageal sphincter relaxations (TLESRs). Intra‐bolus pressure (IBP) is considered to be correlated to esophageal wall tone. We aimed to evaluate the relationship between IBP, TSPG during TLESRs and the dynamic properties of refluxate in gastroesophageal reflux disease. Sixteen non‐erosive reflux disease (NERD), 10 erosive disease (ERD) patients and 12 healthy volunteers (HVs), underwent 24‐hour impedance‐pH monitoring and combined high‐resolution manometry‐impedance before and 60 min...
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Authors: M. Ribolsi, P. Balestrieri, R. H Holloway, S. Emerenziani, M. Cicala Tags: Original Article Source Type: research
Prevalence and predictors of anxiety and depression among esophageal cancer patients prior to surgery
This study aims to establish the prevalence and predictors of anxiety and depression among esophageal cancer patients, post‐diagnosis but prior to curatively intended surgery. This was a cross‐sectional study using data from a hospital‐based prospective cohort study, carried out at St Thomas' Hospital, London. Potential predictor variables were retrieved from medical charts and self‐report questionnaires. Anxiety and depression were measured prior to esophageal cancer surgery, using the Hospital Anxiety and Depression Scale. Prevalence of anxiety and depression was calculated using the established cutoff (scores ...
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Authors: Y. Hellstadius, J. Lagergren, J. Zylstra, J. Gossage, A. Davies, C. M Hultman, P. Lagergren, A. Wikman Tags: Original Article Source Type: research
Aggressive bougie dilatation and intralesional steroids is effective in refractory benign esophageal strictures secondary to corrosive ingestion
Summary
Endoscopic dilatation of corrosive esophageal strictures is effective, but some patients are refractory to it and require long‐term repeated dilatations. The present study was carried out to analyze whether rigorous schedule of endoscopic bougie dilatation along with intralesional injection of triamcinolone in patients refractory to endoscopic dilatation alone could decrease the number and frequency of endoscopic dilatations. The inclusion criterion for this prospective study was patients with refractory corrosive esophageal stricture of any age group. Refractory benign esophageal stricture is defined as an anato...
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Authors: S. Nijhawan, H. P. Udawat, P. Nagar Tags: Original Article Source Type: research
Clinical features and treatment of patients with esophageal cancer and a history of gastrectomy: a multicenter, questionnaire survey in Kyushu, Japan
Summary
It is still controversial whether patients with a history of gastrectomy have high risk of esophageal carcinogenesis. On the other hand, the treatment strategy for esophageal cancer patients after gastrectomy is complicated. The association between histories of gastrectomy and esophageal carcinogenesis was retrospectively analyzed, and the treatment of esophageal cancer patients after gastrectomy was evaluated based on questionnaire data collected from multiple centers in Kyushu, Japan. The initial subject population comprised 205 esophageal cancer patients after gastrectomy. Among them, 108 patients underwent cura...
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Authors: H. Okumura, N. Mori, T. Tanaka, M. Morita, Y. Toh, H. Saeki, Y. Maehara, K. Nakamura, H. Honda, N. Yoshida, H. Baba, S. Natsugoe Tags: Original Article Source Type: research
Sunitinib modulates the radiosensitivity of esophageal squamous cell carcinoma cells in vitro
This study aims to explore the radiosensitivity of sunitinib on esophageal cancer cell lines. For in vitro studies, human esophageal squamous cell carcinoma (ESCC) cell lines were treated with sunitinib 24 hours before irradiation. ESCC cell lines were treated with sunitinib with or without radiation. Cell proliferation was detected by Cell Counting Kit 8 assay. Radiosensitization was evaluated by clonogenic survival assay. Cell apoptosis and cell cycle analysis were detected by flow cytometry. Deoxyribonucleic acid (DNA) double‐strand breaks were performed by immunocytofluorescence analysis. Western blot analysis was ...
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Authors: Y.‐Q. Ding, H.‐C. Zhu, X.‐C. Chen, X.‐C. Sun, X. Yang, Q. Qin, H. Zhang, Y. Yang, Y.‐H. Yang, L. Gao, J.‐D. Luo, X.‐F. Zhou Tags: Original Article Source Type: research
