Short ‐term and long‐term effect of diaphragm biofeedback training in gastroesophageal reflux disease: an open‐label, pilot, randomized trial
In conclusion, long‐term DBT could reduce acid suppression usage by enhancing the anti‐reflux barrier, providing a non‐pharmacological maintenance therapy and reducing medical costs for patients with GERD. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - July 29, 2015 Category: Gastroenterology Authors: X. Sun, W. Shang, Z. Wang, X. Liu, X. Fang, M. Ke Tags: Benign Esophageal Disease Source Type: research
Issue Information
(Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - July 14, 2015 Category: Gastroenterology Tags: Issue Information Source Type: research
Adherence to a predominantly Mediterranean diet decreases the risk of gastroesophageal reflux disease: a cross‐sectional study in a South Eastern European population
Summary
Our aim was to assess the association of a Mediterranean diet and gastroesophageal reflux disease among adult men and women in Albania, a former communist country in South Eastern Europe with a predominantly Muslim population. A cross‐sectional study was conducted in 2012, which included a population‐based sample of 817 individuals (≥18 years) residing in Tirana, the Albanian capital (333 men; overall mean age: 50.2 ± 18.7 years; overall response rate: 82%). Assessment of gastroesophageal reflux disease was based on Montreal definition. Participants were interviewed about their dietary patterns, which in the...
Source: Diseases of the Esophagus - July 14, 2015 Category: Gastroenterology Authors: I. Mone, B. Kraja, A. Bregu, V. Duraj, E. Sadiku, J. Hyska, G. Burazeri Tags: Original Article Source Type: research
Association between the thoroughness of the histopathological examination and survival in patients with esophageal squamous cell carcinoma who achieve pathological complete response after chemoradiotherapy
Summary
The College of American Pathologists guidelines recommend examining at least four representative tumor blocks for determining pathological T stage in patients with primarily resected esophageal cancer. Whether the same pathological requirements are adequate in patients undergoing esophagectomy following neoadjuvant chemoradiotherapy (nCRT) remains unclear. We hypothesized that current examination protocols may underestimate the presence of microscopical residual disease after nCRT, potentially leading to under‐staging. We retrospectively reviewed the records of patients with esophageal squamous cancer (ESCC) who ...
Source: Diseases of the Esophagus - July 14, 2015 Category: Gastroenterology Authors: Chien‐Hung Chiu, W‐H. Chen, Y‐W. Wen, C‐J. Yeh, Y‐K. Chao, H‐K. Chang, C‐K. Tseng, Y‐H. Liu Tags: Original Article Source Type: research
Interrogation of esophagogastric junction barrier function using the esophagogastric junction contractile integral: an observational cohort study
Summary
The esophagogastric junction contractile integral (EGJ‐CI), designed similar to distal contractile integral (DCI), has been proposed as a metric to evaluate EGJ barrier function. We determined normative values and evaluated EGJ‐CI in predicting esophageal acid exposure time (AET) and symptomatic outcome in this observational cohort study. High‐resolution manometry (HRM) studies were reviewed in 188 patients (55.2 ± 0.9 years, 64% female) undergoing ambulatory pH monitoring off therapy. Dominant symptoms and global symptom severity (GSS) were determined on questionnaires initially and upon follow‐up. EGJ...
Source: Diseases of the Esophagus - July 14, 2015 Category: Gastroenterology Authors: P. Gor, Y. Li, S. Munigala, A. Patel, A. Bolkhir, C. P. Gyawali Tags: Original Article Source Type: research
Characterization of oncocytes in deep esophageal glands
Summary
Deep esophageal glands play a vital role in the protection and regeneration of the esophageal mucosa. Conditions such as gastroesophageal reflux disease and Barrett's esophagus have been associated with a change in the usual glands by oncocytic metaplasia. However, little is known regarding the function of oncocytes or the relevance of this metaplastic change in the human esophagus. We hypothesized that oncocytes of deep esophageal glands also express markers characteristic of a ductal epithelial phenotype because similar oncocytes have been described as part of large ductal epithelial cells in salivary glands. We ...
Source: Diseases of the Esophagus - July 1, 2015 Category: Gastroenterology Authors: G. Gonzalez, Q. Huang, H. Mashimo Tags: Original Article Source Type: research
Esophagogastric junctional adenocarcinoma originating from endoscopically unrecognizable Barrett's epithelium
(Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - July 1, 2015 Category: Gastroenterology Authors: K. Nagai, Y. Tsujii, T. Matsui, S. Yoshii, T. Fujinaga, A. Maekawa, T. Inoue, Y. Hayashi, S. Shinzaki, H. Iijima, M. Tsujii, E. Morii, T. Takehara Tags: Images in Esophageal Diseases Source Type: research
Peroral endoscopic myotomy for the treatment of esophageal achalasia: systematic review and pooled analysis
In conclusion, POEM is a safe and effective treatment for achalasia, showing significant improvements in objective metrics and achalasia‐related symptoms. Randomized comparative studies of LHM and POEM are required to determine the most effective treatment modality for achalasia. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - July 1, 2015 Category: Gastroenterology Authors: K. Patel, N. Abbassi‐Ghadi, S. Markar, S. Kumar, P. Jethwa, G. Zaninotto Tags: Review Article Source Type: research
Impact of metabolic syndrome on the survival of Chinese patients with resectable esophageal squamous cell carcinoma
SummaryMetabolic syndrome (MetS) is associated with the risk of esophageal squamous cell carcinoma (ESCC). However, the impact of MetS on survival has not been evaluated. A retrospective review was performed on 596 consecutive Chinese patients with esophageal squamous cell carcinoma who received surgery between January 2005 and October 2007. The clinical data and pretreatment information related to MetS were reviewed. The impact of MetS on overall survival (OS) was estimated by Kaplan–Meier and Cox proportional hazards analyses. MetS was a significant and independent predictor for better survival in patients with resecta...
Source: Diseases of the Esophagus - June 30, 2015 Category: Gastroenterology Authors: Y.‐S. Wen, C. Huang, X. Zhang, R. Qin, P. Lin, T. Rong, L.‐J. Zhang Tags: Original Article Source Type: research
Learning curve for endoscopic submucosal dissection of esophageal neoplasms
SummaryThere is a significant learning curve for endoscopic submucosal dissection of esophageal neoplasms that has not been fully characterized. This retrospective study included 33 consecutive superficial esophageal neoplasms for analysis of the learning curve for esophageal endoscopic submucosal dissection based on a single, novice endoscopist's experience. The study was divided into three periods (T1, T2, and T3) of 10 endoscopic submucosal dissection procedures in chronological order, with 13 procedures in the last period. Patient factors (age, sex, coexistent esophageal varices, or submucosal fibrosis) and tumor facto...
Source: Diseases of the Esophagus - June 30, 2015 Category: Gastroenterology Authors: Y.‐K. Tsou, W.‐Y. Chuang, C.‐Y. Liu, K. Ohata, C.‐H. Lin, M.‐S. Lee, H.‐T. Cheng, C.‐T. Chiu Tags: Original Article Source Type: research
Prognostic and clinical impact of sarcopenia in esophageal squamous cell carcinoma
Summary
Recently, depletion of skeletal muscle mass (sarcopenia) has been linked to poor prognosis in several types of cancers, but has not been investigated in esophageal squamous cell carcinoma (ESCC). This retrospective study investigates the relationship between sarcopenia and clinical outcome in ESCC patients treated by surgical resection or definitive chemoradiation therapy (dCRT). The study was retrospectively conducted in a single academic hospital in Kumamoto, Japan, and involved 325 ESCC patients (256 surgical cases and 69 dCRT cases) treated between April 2005 and April 2011. Skeletal muscle mass was quantified ...
Source: Diseases of the Esophagus - June 30, 2015 Category: Gastroenterology Authors: K. Harada, S. Ida, Y. Baba, T. Ishimoto, K. Kosumi, R. Tokunaga, D. Izumi, M. Ohuchi, K. Nakamura, Y. Kiyozumi, Y. Imamura, M. Iwatsuki, S. Iwagami, Y. Miyamoto, Y. Sakamoto, N. Yoshida, M. Watanabe, H. Baba Tags: Original Article Source Type: research
Loss of JAM‐C leads to impaired esophageal innervations and megaesophagus in mice
In this study, we reported that junctional adhesion molecule C (JAM‐C) knockout mice on a C57/B6 background developed progressive megaesophagus from embryonic day (E) 15.5 onward with complete penetrance. JAM‐C knockout mice exhibited a significant reduction in the number of nerve fibers/ganglia in the wall of the esophagus. However, histological analysis revealed that the esophageal wall thickness and structure of JAM‐C knockout mice at embryonic stages and young adult were comparable to that of control littermates. Thus, megaesophagus observed in JAM‐C knockout mice could be attributed, at least in part, to impai...
Source: Diseases of the Esophagus - June 30, 2015 Category: Gastroenterology Authors: M. Ye, Q. Zhang, X. Xu, Q. Zhang, Y. Ge, P. Geng, J. Yan, L. Luo, Y. Sun, X. Liang Tags: Original Article Source Type: research
Loss of JAM ‐C leads to impaired esophageal innervations and megaesophagus in mice
In this study, we reported that junctional adhesion molecule C (JAM‐C) knockout mice on a C57/B6 background developed progressive megaesophagus from embryonic day (E) 15.5 onward with complete penetrance. JAM‐C knockout mice exhibited a significant reduction in the number of nerve fibers/ganglia in the wall of the esophagus. However, histological analysis revealed that the esophageal wall thickness and structure of JAM‐C knockout mice at embryonic stages and young adult were comparable to that of control littermates. Thus, megaesophagus observed in JAM‐C knockout mice could be attributed, at least in part, to impai...
Source: Diseases of the Esophagus - June 29, 2015 Category: Gastroenterology Authors: M. Ye, Q. Zhang, X. Xu, Q. Zhang, Y. Ge, P. Geng, J. Yan, L. Luo, Y. Sun, X. Liang Tags: Physiology/Translational Science Source Type: research
Fluorescence in situ hybridization identifies high risk Barrett's patients likely to develop esophageal adenocarcinoma
Summary
Barrett's esophagus (BE) with high‐grade dysplasia (HGD) defines a group of individuals at high risk of progression to esophageal adenocarcinoma (EA). Fluorescence in situ hybridization (FISH) has been shown to be useful for the detection of dysplasia and EA in endoscopic brushing specimens from BE patients. The aim of this study was to determine whether FISH in combination with histological findings would further identify more rapid progressors to EA. This is a retrospective cohort study of high‐risk patients, having a history of biopsy‐confirmed HGD without EA, with an endoscopic brushing specimen analyzed ...
Source: Diseases of the Esophagus - June 5, 2015 Category: Gastroenterology Authors: S. M. Brankley, K. C. Halling, S. M. Jenkins, M. R. Timmer, P. G. Iyer, T. C. Smyrk, E. G. Barr Fritcher, J. S. Voss, B. R. Kipp, M. B. Campion, L. S. Lutzke, D. M. Minot, K. K. Wang Tags: Original Article Source Type: research
Complications after esophagectomy: it is time to speak the same language
(Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - June 5, 2015 Category: Gastroenterology Authors: G. Zaninotto, D. E. Low Tags: Editorial Source Type: research
