Preoperative carboplatin and paclitaxel‐based chemoradiotherapy for esophageal carcinoma: results of a modified CROSS regimen utilizing radiation doses greater than 41.4 Gy
SummaryTrimodality therapy for resectable esophageal and gastroesophageal junction cancers utilizing preoperative radiotherapy with concurrent carboplatin and paclitaxel‐based chemotherapy is being increasingly utilized secondary to the results of the phase III CROSS trial. However, there is a paucity of reports of this regimen as a component of chemoradiotherapy in North America. We aim to report on our clinical experience using a modified CROSS regimen with higher radiotherapy doses. Patients with advanced (cT2–cT4 or node positive) esophageal or gastroesophageal junction carcinoma who received preoperative carboplat...
Source: Diseases of the Esophagus - June 5, 2015 Category: Gastroenterology Authors: N. Nabavizadeh, R. Shukla, D. A. Elliott, T. Mitin, G. M. Vaccaro, J. P. Dolan, R. J. Maggiore, P. H. Schipper, J. G. Hunter, C. R. Thomas, J. M. Holland Tags: Original Article Source Type: research
Preoperative carboplatin and paclitaxel ‐based chemoradiotherapy for esophageal carcinoma: results of a modified CROSS regimen utilizing radiation doses greater than 41.4 Gy
SummaryTrimodality therapy for resectable esophageal and gastroesophageal junction cancers utilizing preoperative radiotherapy with concurrent carboplatin and paclitaxel‐based chemotherapy is being increasingly utilized secondary to the results of the phase III CROSS trial. However, there is a paucity of reports of this regimen as a component of chemoradiotherapy in North America. We aim to report on our clinical experience using a modified CROSS regimen with higher radiotherapy doses. Patients with advanced (cT2–cT4 or node positive) esophageal or gastroesophageal junction carcinoma who received preoperative carboplat...
Source: Diseases of the Esophagus - June 4, 2015 Category: Gastroenterology Authors: N. Nabavizadeh, R. Shukla, D. A. Elliott, T. Mitin, G. M. Vaccaro, J. P. Dolan, R. J. Maggiore, P. H. Schipper, J. G. Hunter, C. R. Thomas, J. M. Holland Tags: Malignant Esophageal Disease Source Type: research
Overexpression of HSP47 in esophageal squamous cell carcinoma: clinical implications and functional analysis
In this study, we explored the role and evaluated the prognostic value of HSP47 expression in ESCC. The function of this protein was analyzed by assaying proliferation, wound healing, and colony formation in an HSP47‐knockdown ESCC line. The prognostic implication of HSP47 expression was analyzed by immunohistochemical staining in 157 surgical specimens. HSP47 expression level and other clinical variables were analyzed using multivariate Cox proportional hazards models. Silencing of the HSP47 gene in the ESCC cell line inhibited cell proliferation and colony formation. HSP47 was highly expressed in ESCC tissue samples, c...
Source: Diseases of the Esophagus - May 8, 2015 Category: Gastroenterology Authors: H. W. Lee, J. Kwon, M. C. Kang, M.‐K. Noh, J. S. Koh, J. H. Kim, J. H. Park Tags: Original Article Source Type: research
Pilot study special AT‐rich sequence‐binding protein 1 investigating as a potential biomarker for esophageal squamous cell carcinoma
In conclusion, these results suggest that high SATB1 expression is predictive of poor prognosis in ESCC and may be a promising new candidate for targeted therapies for ESCC. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - May 8, 2015 Category: Gastroenterology Authors: Q.‐X. Cong, H. Zhang, S.‐X. Sun, H.‐F. Li, Y. Wang, S. Jian Tags: Original Article Source Type: research
Volumetric laser endomicroscopy in Barrett's esophagus: a feasibility study on histological correlation
Summary
Volumetric laser endomicroscopy (VLE) is a novel balloon‐based optical coherence tomography (OCT) imaging technique that may improve detection of early neoplasia in Barrett's esophagus (BE). Most OCT studies lack a direct correlation between histology and OCT images. The aim is to investigate the optimal approach for achieving one‐to‐one correlation of ex‐vivo VLE images of endoscopic resection (ER) specimens with histology. BE patients with and without early neoplasia underwent ER after delineating areas with electrocoagulation markers (ECM). After ER, specimens underwent additional ex‐vivo marking with ...
Source: Diseases of the Esophagus - May 8, 2015 Category: Gastroenterology Authors: A. Swager, D. F. Boerwinkel, D. M. Bruin, B. L. Weusten, D. J. Faber, S. L. Meijer, T. G. Leeuwen, W. L. Curvers, J. J. Bergman Tags: Original Article Source Type: research
