Reduced toxicity with three‐dimensional conformal radiotherapy or intensity‐modulated radiotherapy compared with conventional two‐dimensional radiotherapy for esophageal squamous cell carcinoma: a secondary analysis of data from four prospective clinical trials
Summary
We conducted a retrospective analysis to assess the toxicity and long‐term survival of esophageal squamous cell carcinoma patients treated with three‐dimensional conformal radiotherapy (3DCRT) or intensity‐modulated radiotherapy (IMRT) versus conventional two‐dimensional radiotherapy (2DRT). All data in the present study were based on four prospective clinical trials conducted at our institution from 1996 to 2004 and included 308 esophageal squamous cell carcinoma patients treated with 2DRT or 3DCRT/IMRT. Based on the inclusion and exclusion criteria, 254 patients were included in the analysis. Of these pat...
Source: Diseases of the Esophagus - December 10, 2015 Category: Gastroenterology Authors: J.‐Y. Deng, C. Wang, X.‐H. Shi, G.‐L. Jiang, Y. Wang, Y. Liu, K.‐L. Zhao Tags: Original Article Source Type: research
Reduced toxicity with three ‐dimensional conformal radiotherapy or intensity‐modulated radiotherapy compared with conventional two‐dimensional radiotherapy for esophageal squamous cell carcinoma: a secondary analysis of data from four prospective clinical trials
Summary
We conducted a retrospective analysis to assess the toxicity and long‐term survival of esophageal squamous cell carcinoma patients treated with three‐dimensional conformal radiotherapy (3DCRT) or intensity‐modulated radiotherapy (IMRT) versus conventional two‐dimensional radiotherapy (2DRT). All data in the present study were based on four prospective clinical trials conducted at our institution from 1996 to 2004 and included 308 esophageal squamous cell carcinoma patients treated with 2DRT or 3DCRT/IMRT. Based on the inclusion and exclusion criteria, 254 patients were included in the analysis. Of these pat...
Source: Diseases of the Esophagus - December 9, 2015 Category: Gastroenterology Authors: J. ‐Y. Deng, C. Wang, X.‐H. Shi, G.‐L. Jiang, Y. Wang, Y. Liu, K.‐L. Zhao Tags: Original Article Source Type: research
Issue Information
(Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - December 1, 2015 Category: Gastroenterology Tags: Issue Information Source Type: research
Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease
This study evaluated the effects of treatment of Chagas disease with ASA on the esophageal nitrergic myenteric neuron population and esophageal wall in mice. We observed that treatment of chagasic infection with ASA protects the esophageal myenteric neurons from the atrophy caused by the Trypanosoma cruzi infection. The mice were infected with 1300 trypomastigotes of Y strain T. cruzi intraperitoneally. Part of infected mice was treated with ASA from fifth to twelfth day after inoculation. Our data support the hypothesis that eicosanoids given during the acute phase of the chagasic infection may act as immunomodulators aid...
Source: Diseases of the Esophagus - November 12, 2015 Category: Gastroenterology Authors: C. L. Massocatto, N. M. Moreira, E. Muniz, P. Pinge‐Filho, R. M. Rossi, E. J. de. A. Araújo, D. de. M. G. Sant'Ana Tags: Original Article Source Type: research
Laparoscopic alternatives to fundoplication for gastroesophageal reflux: the role of magnetic augmentation and electrical stimulation of the lower esophageal sphincter
Summary
Reflux symptoms are very common, and despite modern medication they are a major cause of disease burden and loss of quality of life worldwide. Laparoscopic anti‐reflux surgery is the only current effective alternative but suffers from the risks of long‐term side effects. Surgery also suffers variation in standards and outcomes. Magnetic augmentation and electrical stimulation of the lower esophageal sphincter represent promising innovative procedures in the field. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 12, 2015 Category: Gastroenterology Authors: L. Bonavina, S. Attwood Tags: Original Article Source Type: research
Adjuvant sunitinib following chemoradiotherapy and surgery for locally advanced esophageal cancer: a phase II trial
Summary
The prognosis for locally advanced esophageal cancer is poor despite the use of trimodality therapy. In this phase II study, we report the feasibility, tolerability and efficacy of adjuvant sunitinib. Included were patients with stage IIa, IIB or III cancer of the thoracic esophagus or gastroesophageal junction. Neoadjuvant therapy involved Irinotecan (65 mg/m2) + Cisplatin (30 mg/m2) on weeks 1 and 2, 4 and 5, 7 and 8 with concurrent radiation (50Gy/25 fractions) on weeks 4–8. Sunitinib was commenced 4–13 weeks after surgery and continued for one year. Sixty‐one patients were included in the final analys...
Source: Diseases of the Esophagus - November 12, 2015 Category: Gastroenterology Authors: A. M Horgan, G. Darling, R. Wong, M. Guindi, G. Liu, D. J. Jonker, J. Lister, W. Xu, H. M. MacKay, R. Dinniwell, J. Kim, A. Pierre, Y. Shargall, T. R. Asmis, O. Agboola, A. J. Seely, J. Ringash, J. Wells, E. C. Marginean, M. Haider, J. J. Knox Tags: Original Article Source Type: research
Clinical features and treatment of patients with esophageal cancer and a history of gastrectomy: a multicenter, questionnaire survey in Kyushu, Japan
Diseases of the Esophagus,Volume 29, Issue 8, Page 1135-1143, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Source Type: research
Aggressive bougie dilatation and intralesional steroids is effective in refractory benign esophageal strictures secondary to corrosive ingestion
Diseases of the Esophagus,Volume 29, Issue 8, Page 1027-1031, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Source Type: research
Prevalence and predictors of anxiety and depression among esophageal cancer patients prior to surgery
Diseases of the Esophagus,Volume 29, Issue 8, Page 1128-1134, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Source Type: research
Intra ‐bolus pressure and esophagogastric gradient, assessed with high‐resolution manometry, are associated with acid exposure and proximal migration of refluxate
Diseases of the Esophagus,Volume 29, Issue 8, Page 1020-1026, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Source Type: research
Increasing the interval between neoadjuvant chemoradiotherapy and surgery in esophageal cancer: a meta ‐analysis of published studies
Diseases of the Esophagus,Volume 29, Issue 8, Page 1107-1114, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Source Type: research
Comparison of environmental risk factors for esophageal atresia, anorectal malformations, and the combined phenotype in 263 German families
Diseases of the Esophagus,Volume 29, Issue 8, Page 1032-1042, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Source Type: research
Biobanking of fresh ‐frozen endoscopic biopsy specimens from esophageal adenocarcinoma
Diseases of the Esophagus,Volume 29, Issue 8, Page 1100-1106, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Source Type: research
Co ‐occurrence of eosinophilic esophagitis and potential/probable celiac disease in an adult cohort: a possible association with implications for clinical practice
Diseases of the Esophagus,Volume 29, Issue 8, Page 977-982, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Source Type: research
Effect of baclofen on gastric acid pocket in subjects with gastroesophageal reflux disease symptoms
Diseases of the Esophagus,Volume 29, Issue 8, Page 1054-1063, November/December 2016. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 6, 2015 Category: Gastroenterology Source Type: research
