Effects of high ‐resolution esophageal manometry on oxygen saturation and hemodynamic function
Summary
The effect of high‐resolution esophageal manometry (HRM) on oxygen saturation (SaO2) and hemodynamic function has not been previously evaluated. This was a prospective study of consecutive patients referred for HRM. Demographic and clinical data were collected on all patients. The study variables included SaO2, heart rate (HR) and blood pressure (BP). SaO2 and HR were measured at baseline, during intubation, during and 5 min after HRM. BP was measured at baseline, during and after HRM. 158 (56% women) patients with a mean age of 56 (SD 15) years were included. Thirty‐five (22%) were obese and 55 (35%) were over...
Source: Diseases of the Esophagus - November 8, 2016 Category: Gastroenterology Authors: Vicente Ortiz, Esteban S áez‐González, Michel Blé, Francia Carolina Díaz‐Jaime, Carmen Vinaixa, Vicente Garrigues Tags: Original Article Source Type: research
The natural history of gastro ‐esophageal reflux disease: a comprehensive review
Summary
Gastroesophageal reflux disease (GERD) is a common disorder of the upper gastrointestinal tract which is typically characterized by heartburn and acid regurgitation. These symptoms are widespread in the community and range from 2.5% to more than 25%. Economic analyses showed an increase in direct and indirect costs related to the diagnosis, treatment and surveillance of GERD and its complications. The aim of this review is to provide current information regarding the natural history of GERD, taking into account the evolution of its definition and the worldwide gradual change of its epidemiology. Present knowledge s...
Source: Diseases of the Esophagus - November 8, 2016 Category: Gastroenterology Authors: E. Savarino, N. de Bortoli, C. De Cassan, M. Della Coletta, O. Bartolo, M. Furnari, A. Ottonello, E. Marabotto, G. Bodini, V. Savarino Tags: Review Article Source Type: research
Accuracy of the Air Flow Sphincter Locator system in identifying the lower esophageal sphincter for placement of pH catheters
Summary
The Air Flow Sphincter Locator (AFSL) is marketed as an alternative method to manometry for localizing the lower esophageal sphincter (LES) for pH probe placement. Such a system is desirable due to the additional time, cost, and discomfort associated with dual nasal intubation, but its accuracy has never been assessed. To assess the accuracy of the AFSL in localizing the LES. Fifty consecutive outpatients presenting for pH and manometry studies were included. The upper border of the LES was determined using HRM and the AFSL by two technicians independently. LES locations measured by technicians using AFSL versus ma...
Source: Diseases of the Esophagus - November 8, 2016 Category: Gastroenterology Authors: Joan W. Chen, Jason R. Baker, Jessica M. Compton, Mark McDermott, Joel H. Rubenstein Tags: Original Article Source Type: research
Quality of life and fear of cancer recurrence after endoscopic treatment for early Barrett's neoplasia: a prospective study
Summary
Endoscopic therapy is the treatment of choice for high grade intraepithelial neoplasia (HGIN) or early cancer (≤T1sm1) in Barrett's esophagus (BE). We prospectively evaluated the effect of endoscopic treatment on quality of life (QOL) and fear of cancer (recurrence) and compared this with the effect of Barrett's surveillance or surgery. Patients treated endoscopically for early Barrett's neoplasia (n = 42, HGIN – T1sm1N0M0) were compared with three groups: patients with non‐dysplastic BE undergoing surveillance (n = 44); patients treated surgically for early BE neoplasia (HGIN – T2N0M0, n = 21);...
Source: Diseases of the Esophagus - October 20, 2016 Category: Gastroenterology Authors: Wilda D. Rosmolen, Pythia T. Nieuwkerk, Roos E. Pouw, Mark I. van Berge Henegouwen, Jacques J. G. H. M. Bergman, Mirjam A. G. Sprangers Tags: Original Article Source Type: research
Definitive chemoradiation for locoregional recurrences of esophageal cancer after primary curative treatment
Summary
The aim of this study was to determine the outcome of salvage definitive chemoradiation (dCRT) for a locoregional recurrence after any prior curative treatment outside previously irradiated areas. Thirty‐nine patients treated between January 2005 and December 2014 were reviewed for locoregional recurrent esophageal cancer outside previously irradiated areas. All patients received salvage treatment with external beam radiotherapy (50.4 Gy in 28 fractions) combined with weekly concurrent paclitaxel and carboplatin. The median follow‐up period was 15 months (range 1.7–120). The median overall survival (OS) for a...
Source: Diseases of the Esophagus - October 20, 2016 Category: Gastroenterology Authors: P. M. Jeene, E. Versteijne, M. I. van Berge Henegouwen, J. J. G. H. M. Bergmann, E. D. Geijsen, K. Muller, H. W. M. van Laarhoven, M. C. C. M Hulshof Tags: Original Article Source Type: research
Effect of neoadjuvant chemoradiotherapy on perioperative immune function of patients with locally advanced esophageal cancer
This study aims to evaluate the effect of neoadjuvant chemoradiotherapy (NCRT) on perioperative immune function during surgery to treat resectable locally advanced esophageal cancer. Records were retrospectively analyzed for 220 patients with locally advanced esophageal cancer, of whom 112 received surgery alone and 98 received neoadjuvant NCRT plus surgery. The two groups were compared in terms of proportions of CD3+, CD4+, CD8+, and natural kill (NK) cells, as well as the ratio of CD4+ to CD8+ cells. These measurements were made using flow cytometry on preoperative day 1 and on postoperative days 1 and 7. Subgroup analys...
Source: Diseases of the Esophagus - October 20, 2016 Category: Gastroenterology Authors: Jun ‐Tao Tan, Yang Yang, Nai‐Qun Mao, De‐Sen Liu, Ding‐Ming Huang, Hong Pan, Tong Xie, Qi Pan, Li Yang, Jian‐Hong Zhong, Chuan‐Tian Zuo Tags: Original Article Source Type: research
Perfusion of the gastric conduit during esophagectomy
In this study we aimed to monitor changes in the perfusion of the gastric conduit at key steps during and after esophagectomy. pHi was measured per‐ and postoperatively using intermittent gastric tonometry in 32 patients undergoing open, 65%, or video‐assisted thoracoscopic esophagectomy for esophageal cancer. Measurements focused on the surgical steps when the vascular supply to the gastric conduit was altered. A tonometry catheter was successfully placed in all patients and a decrease in pHi (mean ± SD) was observed from baseline to after the division of the short gastric vessels (7.33 ± 0.07 to 7.29 ± 0.07...
Source: Diseases of the Esophagus - October 20, 2016 Category: Gastroenterology Authors: Gustav Linder, Jakob Hedberg, Martin Bj örck, Magnus Sundbom Tags: Original Article Source Type: research
Worldwide Esophageal Cancer Collaboration: pathologic staging data
We report data—simple descriptions of patient characteristics, cancer categories, and non–risk‐adjusted survival—for patients with pathologically staged cancer of the esophagus and esophagogastric junction after resection or ablation with no preoperative therapy from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty‐three institutions from six continents submitted de‐identified data using standard definitions: demographics, comorbidities, clinical cancer categories, and all‐cause mortality from first management decision. Of 13,300 patients, 5,631 had squamous cell carcinoma, 7,558 adenocarcinoma, 8...
Source: Diseases of the Esophagus - October 11, 2016 Category: Gastroenterology Authors: T. W. Rice, L. ‐Q. Chen, W. L. Hofstetter, B.M. Smithers, V. W. Rusch, B. P. L. Wijnhoven, K. L. Chen, A. R. Davies, X. B. D'Journo, K. A. Kesler, J. D. Luketich, M. K. Ferguson, J. V. Räsänen, R. van Hillegersberg, W. Fang, L. Durand, I. Cecconello, Tags: WECCS Manuscripts Source Type: research
Worldwide Esophageal Cancer Collaboration: neoadjuvant pathologic staging data
SUMMARY
To address uncertainty of whether pathologic stage groupings after neoadjuvant therapy (ypTNM) for esophageal cancer share prognostic implications with pathologic groupings after esophagectomy alone (pTNM), we report data—simple descriptions of patient characteristics, cancer categories, and non–risk‐adjusted survival—for pathologically staged cancers after neoadjuvant therapy from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty‐three institutions from six continents submitted data using variables with standard definitions: demographics, comorbidities, clinical cancer categories, and all‐ca...
Source: Diseases of the Esophagus - October 11, 2016 Category: Gastroenterology Authors: T. W. Rice, T. E. M. R. Lerut, M. B. Orringer, L. ‐Q. Chen, W. L. Hofstetter, B. M. Smithers, V. W. Rusch, J. van Lanschot, K. N. Chen, A. R. Davies, X. B. D'Journo, K. A. Kesler, J. D. Luketich, M. K. Ferguson, J. V. Räsänen, R. van Hillegersberg, W. Tags: WECCS Manuscripts Source Type: research
Worldwide Esophageal Cancer Collaboration: clinical staging data
Summary
To address uncertainty of whether clinical stage groupings (cTNM) for esophageal cancer share prognostic implications with pathologic groupings after esophagectomy alone (pTNM), we report data—simple descriptions of patient characteristics, cancer categories, and non–risk‐adjusted survival—for clinically staged patients from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty‐three institutions from six continents submitted data using variables with standard definitions: demographics, comorbidities, clinical cancer categories, and all‐cause mortality from first management decision. Of 22,123 cl...
Source: Diseases of the Esophagus - October 11, 2016 Category: Gastroenterology Authors: T. W. Rice, C. Apperson ‐Hansen, L. M. DiPaola, M. E. Semple, T. E. M. R. Lerut, M. B. Orringer, L.‐Q. Chen, W. L. Hofstetter, B. M. Smithers, V. W. Rusch, B. P. L. Wijnhoven, K. N. Chen, A. R. Davies, X. B. D'Journo, K. A. Kesler, J. D. Luketich, M. Tags: WECCS Manuscripts Source Type: research
Issue Information
(Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - October 11, 2016 Category: Gastroenterology Tags: Issue Information Source Type: research
Feasibility and safety of peroral endoscopic myotomy for achalasia after failed endoscopic interventions
In this study, we investigated the feasibility and safety of POEM in patients with achalasia after failed endoscopic interventions. Data on all patients undergoing POEM treatment of achalasia were collected prospectively. We enrolled 61 patients who underwent POEM for achalasia between July 2011 and January 2014. The preoperative intervention group included patients who had undergone botulinum toxin injection or pneumatic balloon dilation before POEM. The preoperative, operative, and short‐term outcome data between the groups were compared. Among preoperative intervention group, 22 patients received endoscopic therapy be...
Source: Diseases of the Esophagus - September 30, 2016 Category: Gastroenterology Authors: X. Tang, W. Gong, Z. Deng, J. Zhou, Y. Ren, Q. Zhang, Z. Chen, B. Jiang Tags: Original Manuscript Source Type: research
A high number of stromal tumor ‐infiltrating lymphocytes is a favorable independent prognostic factor in M0 (stages I–III) esophageal squamous cell carcinoma
In conclusion, in addition to tumor stage increasing stromal lymphocytic infiltration is an independent prognostic factor for esophageal squamous cell carcinoma treated by radical resection. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - September 30, 2016 Category: Gastroenterology Authors: Jing Li, Yang Tang, Liu Huang, Qianqian Yu, Guangyuan Hu, Yanmei Zou, Xianglin Yuan Tags: Original Article Source Type: research
Metabolic tumor volume provides complementary prognostic information to EUS staging in esophageal and junctional cancer
Summary
To determine the correlation between 18F‐fluorodeoxyglucose positron emission tomography‐computed tomography (PET‐CT) derived esophageal tumor parameters [maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV)] and endoscopic ultrasound (EUS) derived tumor parameters (T stage, N stage) and their prognostic implications. 150 consecutive patients with cancer of the esophagus or esophagogastric junction underwent staging PET‐CT and staging EUS. PET‐CT derived SUVmax and MTV of the primary tumor was recorded. EUS evaluated T and N stage. Relationships between parameters were investigated usi...
Source: Diseases of the Esophagus - September 30, 2016 Category: Gastroenterology Authors: Vinod Malik, Ciaran Johnston, Dermot O'Toole, Julie Lucey, Naoimh O'Farrell, Zieta Claxton, John V. Reynolds Tags: Original Article Source Type: research
Naso ‐esophageal extraluminal drainage for postoperative anastomotic leak after thoracic esophagectomy for patients with esophageal cancer
Summary
Postoperative anastomotic leaks and subsequent mediastinal abscess are serious complications. The purpose of this study was to assess the efficacy of naso‐esophageal extraluminal drainage after thoracic esophagectomy with gastric conduit reconstruction using a posterior mediastinal route. About 50 of 365 patients (13.7%) with esophageal cancer and postoperative anastomotic leak after curative esophagectomy was investigated. Beginning in June 2009, naso‐esophageal extraluminal drainage by inserting a naso‐esophageal aspiration tube into the abscess cavity when percutaneous abscess drainage was introduced which...
Source: Diseases of the Esophagus - September 30, 2016 Category: Gastroenterology Authors: Kiyohiko Shuto, Tsuguaki Kono, Yasunori Akutsu, Masaya Uesato, Mikito Mori, Kenichi Matsuo, Chihiro Kosugi, Atsushi Hirano, Kuniya Tanaka, Shinich Okazumi, Keiji Koda, Hisahiro Matsubara Tags: Original Article Source Type: research
