Long ‐term benefit of transoral incisionless fundoplication using the esophyx device for the management of gastroesophageal reflux disease responsive to medical therapy
Summary
Transoral incisionless fundoplication (TIF) using the EsophyX device has been shown to be effective and safe in patients with Gastroesophageal reflux disease (GERD); however, the subset of patients that would mostly benefit from this technique remains unknown. The aim of this study was to evaluate the long‐term efficacy and safety of the TIF procedure in patients with a history of esophagitis or proven chronic GERD who have achieved symptom control with the administration of proton pump inhibitors (PPIs) but did not wish to continue receiving medications for life. Forty‐five patients with typical GERD symptoms ...
Source: Diseases of the Esophagus - November 20, 2016 Category: Gastroenterology Authors: Gerasimos Stefanidis, Nikos Viazis, Nikolaos Kotsikoros, Nikolaos Tsoukalas, Eythymia Lala, Loukas Theocharis, Andreas Fassaris, Spilios Manolakopoulos Tags: Original Article Source Type: research
Efficacy and safety of cisplatin ‐based versus nedaplatin‐based regimens for the treatment of metastatic/recurrent and advanced esophageal squamous cell carcinoma: a systematic review and meta‐analysis
Abstract
Cisplatin and nedaplatin show significant antitumor activity and have been widely used for esophageal squamous cell carcinoma (ESCC). However, it is still unclear whether the efficacy and safety of nedaplatin‐based regimens are comparable to those of cisplatin‐based regimens in patients with metastatic/recurrent or advanced ESCC. Therefore, we conducted a systematic review and meta‐analysis to compare the efficacy and safety of these two regimens for the treatment of metastatic/recurrent and advanced ESCC. We systematically searched Pubmed, Web of Science, and the Cochrane Database, as well as abstracts pres...
Source: Diseases of the Esophagus - November 20, 2016 Category: Gastroenterology Authors: Fei Zhang, Yun Wang, Zhi ‐Qiang Wang, Peng Sun, De‐Shen Wang, Yuan‐Xue Jiang, Dong‐Sheng Zhang, Feng‐Hua Wang, Rui‐Hua Xu, Yu‐Hong Li Tags: Original Article Source Type: research
Patterns of reflux in gastroesophageal reflux disease in pediatric population of New South Wales
This study is to determine the association of ambulatory pH monitoring (24hr pH) with symptoms of gastroesophageal reflux and its other investigations. The clinical and epidemiological profiles of subjects referred for reflux disorders are also studied. Symptoms or group of symptoms, profiles and prior investigations of 1259 consecutive pediatric subjects (with 1332 24hr pH studies performed) referred for evaluation of reflux disorders between 1988 and 2012 were retrospectively studied. Chi‐square or fisher exact test was used for hypothesis testing, student t‐test for the comparison of means and the Wilcoxon rank‐su...
Source: Diseases of the Esophagus - November 20, 2016 Category: Gastroenterology Authors: Sarath Kumar Narayanan, Ralph Clinton Cohen, Jonathan Saul Karpelowsky Tags: Original Article Source Type: research
Review of chemotherapeutic approaches for operable and inoperable esophageal squamous cell carcinoma
Summary
The predominant histological types of esophageal cancer are adenocarcinoma and squamous cell carcinoma. Since these two histological types present as different diseases in terms of their epidemiology, pathologenesis, and tumor biology, separate therapeutic approaches should be developed against each type. While surgical resection remains the dominant therapeutic intervention for patients with operable esophageal squamous cell carcinoma (ESCC), their high rates of tumor recurrence have prompted investigation of multimodality therapies that combine surgery with chemotherapy, radiotherapy, and chemoradiotherapy. In Ja...
Source: Diseases of the Esophagus - November 20, 2016 Category: Gastroenterology Authors: Y. Baba, H. Saeki, Y. Nakashima, E. Oki, H. Shigaki, N. Yoshida, M. Watanabe, Y. Maehara, H. Baba Tags: Review Article Source Type: research
Development of a nomogram for the prediction of pathological complete response after neoadjuvant chemoradiotherapy in patients with esophageal squamous cell carcinoma
Summary
Nomograms incorporating multiple prognostic factors are useful for individualized estimation of survival in cancer patients. However, nomograms for the prediction of pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in patients with esophageal cancer are scarce. Here, we describe the development of a nomogram for predicting pCR after nCRT in patients with esophageal squamous cell carcinoma (ESCC). We retrospectively reviewed the records of 392 ESCC patients who underwent nCRT followed by esophagectomy. Seventy percent of the participants (n = 274) were randomly assigned to a traini...
Source: Diseases of the Esophagus - November 20, 2016 Category: Gastroenterology Authors: Yin ‐Kai Chao, Hsien‐Kun Chang, Chen‐Kan Tseng, Yun‐Hen Liu, Yu‐Wen Wen Tags: Original Article Source Type: research
P21, COX ‐2, and E‐cadherin are potential prognostic factors for esophageal squamous cell carcinoma
Summary
Much research effort has been devoted to identifying prognostic factors for esophageal squamous cell carcinoma (ESCC) by immunohistochemistry; however, no conclusive findings have been reached thus far. We hypothesized that certain molecules identified in previous studies might serve as useful prognostic markers for ESCC. Therefore, the aim of the current study was to validate the most relevant markers showing potential for ESCC prognosis in our prospective esophageal cancer database. A literature search was performed using the PubMed database for papers published between 1980 and 2015 using the following key words...
Source: Diseases of the Esophagus - November 20, 2016 Category: Gastroenterology Authors: Yao Lin, Lu ‐Yan Shen, Hao Fu, Bin Dong, He‐Li Yang, Wan‐Pu Yan, Xiao‐Zheng Kang, Liang Dai, Hai‐Tao Zhou, Yong‐Bo Yang, Zhen Liang, Ke‐Neng Chen Tags: Original Article Source Type: research
Effects of eosinophilic oesophagitis on quality of life in an adult UK population: a case control study
Summary
Eosinophilic oesophagitis (EoE) is a chronic immune‐mediated esophageal disease, characterized by symptoms related to esophageal dysfunction and histologically by eosinophil predominant inflammation. Current evidence for an adverse impact on quality of life (QoL) is conflicting and there are no data from a UK population regarding QoL. We conducted a prospective cross‐sectional observational study using the Short Form‐36 Health Survey, Hospital Dysphagia/Odynophagia Questionnaire, and the EoE Adult Quality of Life Questionnaire to assess QoL and severity of dysphagia in EoE patients, compared to age and gender...
Source: Diseases of the Esophagus - November 20, 2016 Category: Gastroenterology Authors: R. Hewett, C. Alexakis, A. D. Farmer, J. Ainley, V. Chhaya, J. O. Hayat, A. Poullis, J. ‐Y. Kang Tags: Original Article Source Type: research
Outcomes of definitive chemoradiation in patients with esophageal cancer
Summary
The incidence of esophageal cancer has risen dramatically in the Western world. Although surgical resection of esophageal tumors is considered the cornerstone of curative approaches in localized esophageal cancer, approximately 40% of patients who undergo chemoradiation followed by surgery will experience a recurrence. Additionally, surgical resection is not a viable option for many patients with locally advanced unresectable disease, poor general condition or whose condition deteriorated following chemoradiation. Several investigators have, therefore, attempted to evaluate the outcomes of definitive chemoradiation...
Source: Diseases of the Esophagus - November 20, 2016 Category: Gastroenterology Authors: Sameh Mikhail, Lai Wei, Mohamed E. Salem, Tanios Bekaii ‐Saab Tags: Review Article Source Type: research
Dumping syndrome after esophagectomy: a systematic review of the literature
(Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 8, 2016 Category: Gastroenterology Authors: Piers R. Boshier, Jeremy R. Huddy, Giovanni Zaninotto, George B. Hanna Tags: Review Article Source Type: research
Comparison of curative surgery and definitive chemoradiotherapy as initial treatment for patients with cervical esophageal cancer
In conclusion, curative surgery and chemoradiotherapy as initial treatment for cervical esophageal cancer have comparable survival outcomes. Chemoradiotherapy should be selected as the initial larynx‐preserving treatment for patients with cervical esophageal cancer although chemoradiotherapy non‐responders require additional treatment, including salvage surgery. (Source: Diseases of the Esophagus)
Source: Diseases of the Esophagus - November 8, 2016 Category: Gastroenterology Authors: Katsushi Takebayashi, Yasuhiro Tsubosa, Satoru Matsuda, Keisuke Kawamorita, Masahiro Niihara, Takahiro Tsushima, Tomoya Yokota, Hiroshi Sato, Yusuke Onozawa, Hirofumi Ogawa, Tomoyuki Kamijo, Tetsuro Onitsuka, Masahiro Nakagawa, Hirofumi Yasui Tags: Original Article Source Type: research
Treatment and survival outcomes of small cell carcinoma of the esophagus: an analysis of the National Cancer Data Base
In this study, the National Cancer Data Base (NCDB) was utilized to analyze the clinical features, treatment, and survival of patients with esophageal SCC in a large, population‐based dataset. We selected patients diagnosed with esophageal SCC from 1998 to 2011. Patients were identified as having no treatment, chemotherapy alone, radiation ± sequential chemotherapy, concurrent chemoradiation, and esophagectomy ± chemotherapy and/or radiation. Overall survival (OS) was analyzed using the Kaplan–Meier method and compared using the log‐rank test. Multivariate Cox regression analysis was conducted to identify f...
Source: Diseases of the Esophagus - November 8, 2016 Category: Gastroenterology Authors: Andrew T. Wong, Meng Shao, Justin Rineer, Virginia Osborn, David Schwartz, David Schreiber Tags: Original Article Source Type: research
The physiotherapist and the esophageal cancer patient: from prehabilitation to rehabilitation
Summary
Esophageal cancer is a serious malignancy often treated with multimodal interventions and complex surgical resection. As treatment moves to centers of excellence with emphasis on enhanced recovery approaches, the role of the physiotherapist has expanded. The aim of this review is to discuss the rationale behind both the evolving prehabilitative role of the physiotherapist and more established postoperative interventions for patients with esophageal cancer. While a weak association between preoperative cardiopulmonary fitness and post‐esophagectomy outcome is reported, cardiotoxicity during neoadjuvant chemotherap...
Source: Diseases of the Esophagus - November 8, 2016 Category: Gastroenterology Authors: E. M. Guinan, J. Dowds, C. Donohoe, J. V. Reynolds, J. Hussey Tags: Review Article Source Type: research
Patterns of care and survival outcomes in the treatment of esophageal melanoma
Summary
Because of the rarity of esophageal melanoma, the optimal management of this disease is limited. The pooled dataset in the National Cancer Database (NCDB) was used to identify the prognostic factors and treatment outcomes. Patients who were diagnosed with esophageal melanoma between 2004 and 2011 were identified. Patients were stratified as either localized (T1‐4N0M0), regional (T1‐4N+M0), or metastatic (M1). The primary endpoint of this study was overall survival (OS) which was analyzed using the Kaplan–Meier method and multivariate Cox regression, which was performed to identify potential factors influencin...
Source: Diseases of the Esophagus - November 8, 2016 Category: Gastroenterology Authors: Joseph P. Weiner, Meng Shao, David Schwartz, Andrew Wong, David Schreiber Tags: Original Article Source Type: research
An age ‐period‐cohort analysis of obesity and incident esophageal adenocarcinoma among white males
Summary
The incidence of esophageal adenocarcinoma (EAC) has increased in recent decades. Increases in incidence have been attributed to changes in the prevalence of risk factors for EAC; however, the extent to which these changes explain increases in EAC incidence has not been studied in detail. We used age‐period‐cohort analysis to estimate changes in the incidence of EAC among white males by age, time period, and birth cohort. Incidence rates per 100,000 individuals were analyzed from 1973 to 2012. Hierarchical Poisson models were used to estimate age, period, and cohort effects, whereby age‐specific incidence rat...
Source: Diseases of the Esophagus - November 8, 2016 Category: Gastroenterology Authors: Caitlin C. Murphy, Y. Claire Yang, Nicholas J. Shaheen, Wayne L. Hofstetter, Robert S. Sandler Tags: Original Article Source Type: research
Comparison of synchronous versus staged surgeries for patients with synchronous double cancers of the esophagus and head ‐and‐neck
Summary
Esophageal and head and neck (H&N) cancers often occur synchronously, this study aimed to clarify the benefits and disadvantages of synchronous and staged operations for double H&N/esophagus cancers. We retrospectively reviewed 43 patients with synchronous double cancer of H&N and esophagus treated between July 2005 and July 2014, of whom 33 patients underwent synchronous operation (SYN) and 10 underwent staged operations (STG). We compared the short‐term outcomes between the groups. Operation time was longer, amount of blood loss was larger, and hospital stay was longer in the SYN group than in each ...
Source: Diseases of the Esophagus - November 8, 2016 Category: Gastroenterology Authors: Akira Matsumoto, Masayuki Watanabe, Shinji Mine, Koujiro Nishida, Hironobu Shigaki, Kazuyoshi Kawabata, Katsuhiko Yanaga, Takeshi Sano Tags: Original Article Source Type: research
