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A validated stability indicating DAD–HPLC method for determination of pentoxifylline in presence of its pharmacopeial related substances
Publication date: December 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 2 Author(s): Mohamed A. Korany , Rim S. Haggag , Marwa A.A. Ragab , Osama A. Elmallah A validated, simple and sensitive stability-indicating HPLC method was introduced for the analysis of Pentoxifylline in the presence of its pharmacopeial related substances, Caffeine anhydrous and Theophylline anhydrous, in the presence of its forced degradation products. This was achieved using a gradient DAD–HPLC method in order to achieve a good separation between the related substance peaks, complying with the pharmacop...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Grape seed extract attenuates hyperglycaemia-induced in rats by streptozotocin
Publication date: December 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 2 Author(s): Sally A. El-Awdan , Gehad A. Abdel Jaleel , Dalia O. Saleh The current study aimed to investigate the possible beneficial effects of grape seed extract (GSE) on some metabolic and biochemical changes associated with streptozotocin (STZ; 50mg/kg; i.p.)-induced hyperglycaemia in male rats. Blood samples were used to determine serum levels of glucose, insulin, total cholesterol (TC) and triglycerides (TG). Some biochemical markers for oxidative stress viz., serum lipid peroxides level (measured as mal...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Development and optimization of fast dissolving oro-dispersible films of granisetron HCl using Box–Behnken statistical design
Publication date: December 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 2 Author(s): Hema Chaudhary , Samita Gauri , Permender Rathee , Vikash Kumar The aim was to develop and optimize fast dissolving oro-dispersible films of granisetron hydrochloride (GH) by two-factor, three-level Box–Behnken design as the two independent variables such as X1 (polymer) and X2 (plasticizer) were selected on the basis of the preliminary studies carried out before the experimental design is being implemented. A second-order polynomial equation to construct contour plots for the prediction of re...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

HPLC-DAD stability indicating determination of nizatidine in bulk and capsules dosage form
Publication date: December 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 2 Author(s): Tarek S. Belal , Mohamed H. Abdel-Hay , Suzy M. Sabry , Ahmed A. Mahgoub This work describes the stability-indicating determination of the H2-receptor antagonist nizatidine in its bulk and capsules dosage form using high performance liquid chromatography coupled with diode array detector (HPLC-DAD). The developed method involved the use of Thermo Hypersil BDS-C8 (4.6×250mm, 5μm particle size) column and a mobile phase composed of 0.05M phosphoric acid and acetonitrile (50:50, v/v). The mobile ph...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Determination of ofloxacin and dexamethasone in Dexaflox eye drops through different ratio spectra manipulating methods
Publication date: December 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 2 Author(s): M. Nebsen , Ghada M. Elsayed , M. AbdelKawy , S.Z. ELkhateeb Different sensitive and selective spectrophotometric methods for the determination of ofloxacin and dexamethasone in their binary mixture were presented. Ofloxacin was determined simply by zero order at its λ max 293.4nm in a linear range of 1.5–12μgmL−1 with mean percentage recovery of 100.07±0.66% without any interference of dexamethasone even in low or high concentrations. Dexamethasone was determined by first derivative of rat...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Synthesis and evaluation of antioxidant activity of novel 3,5-disubstituted-2-pyrazolines
Publication date: December 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 2 Author(s): Akshay Kumar , Bhat G. Varadaraj , Rajeev K. Singla Driven by the increased demand of pyrazolines exhibiting biological activities like antioxidant, anti-inflammatory, antidepressant, antimicrobial, antitumor, and antitubercular drug activity as a stable fragment in biological moieties, lead us to synthesize 2-pyrazolines by the condensation of various substituted chalcones and hydrazine hydrate in the presence of ethanol. The structure of the synthesized molecules was confirmed on the basis of phy...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Botanical and genetic characteristics of Farsetia aegyptia Turra growing in Egypt
Publication date: December 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 2 Author(s): Walaa M. Ismail , Amira Abdel Motaal , Nadia M. Sokkar , Ahlam M. El-Fishawy Farsetia aegyptia Turra is a perennial woody desert shrub native to Egypt. It is used by native Bedouins as an anti-diabetic and antispasmodic. Study of the botanical features was carried out for the root, young and old stems, leaf, fruit and seed of the plant. F. aegyptia Turra was characterized by the presence of myrosin cells and non-glandular branched unicellular two-armed hairs in the stem, leaves and fruit, while t...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Spectrophotometric and spectrofluorimetric methods for the determination of saxagliptin and vildagliptin in bulk and pharmaceutical preparations
Publication date: December 2013 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 51, Issue 2 Author(s): Marwa S. Moneeb New simple and sensitive spectrophotometric and spectrofluorimetric methods have been developed and validated for the determination of saxagliptin (SAX) and vildagliptin (VDG) in bulk and pharmaceutical preparations. The spectrophotometric methods were based on derivatization of the investigated drugs with two reagents: 1,2-naphthoquinone-4-sulfonic acid sodium salt (NQS) and 4-chloro-7-nitrobenzofurazan (NBD-Cl). For further increase in the sensitivity, the D 1 spectra of the reactio...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Streptozotocin-induced vascular and biochemical changes in rats: Effects of rosiglitazone vs. metformin
In conclusion both drugs show beneficial effects against the vascular dysfunction associated with hyperglycaemia which might be related to their euglycaemic activity in addition to anti-oxidant property of rosiglitazone and a direct effect of metformin on vascular smooth muscle. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Micellar liquid chromatographic determination of sertaconazole and terconazole in bulk, pharmaceutical dosage forms and spiked human plasma
Publication date: June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 1 Author(s): Mohamed Rizk , Safaa S. Toubar , Maha M.A. El-Alamin , Marwa M.M. Azab A micellar liquid chromatographic method was developed for the determination of sertaconazole and terconazole in bulk, dosage forms and human plasma using intersil cyano column and mobile phase consisting of 0.1M sodium dodecyl sulphate, 20% 1-propanol, and 0.3% triethylamine in 0.02M ortho-phosphoric acid (pH 4) at 225nm. Different chromatographic parameters were studied, e.g. types of columns, pH of mobile phase, concentration of...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Pharmacology and phytochemistry studies in Peltophorum africanum
Publication date: June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 1 Author(s): Ofentse Mazimba Peltophorum africanum Sond is an ethnomedicinal plant in the family Fabaceae. This literature report captures information about the ethnomedical uses, pharmacology and phytochemistry of P. africanum within the last four decades. The literature surveyed revealed the presence of different types of polyphenols whose content was higher in the bark and roots than the leaves. The plant polar extracts are rich in phenolic compounds and shows high antioxidant properties. The root and stem extrac...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Pharmacoeconomic study of antibiotics used in the treatment of lower respiratory tract infections in ICU patients: A case study in an Egyptian hospital
In conclusion, regimens containing or not containing fluoroquinolone did not show a significant increase in either effectiveness or costs of CAP treatment in the ICU. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

CoMFA and docking study of 2,N6-disubstituted 1,2-dihydro-1,3,5-triazine-4,6-diamines as novel PfDHFR enzyme inhibitors for antimalarial activity
Publication date: June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 1 Author(s): Pritam N. Dube , Santosh Mokale , Prasanna Datar A three-dimensional quantitative structure–activity relationship (3D-QSAR) study was performed on 1,3,5-triazine derivatives which were based on Ala16Val+Ser108Thr mutant DHFR inhibitors of Plasmodium falciparum clone (FCR-3). Comparative Molecular Field Analysis (CoMFA) was carried out for designing novel PfDHFR enzyme inhibitors. It is shown that the steric and electrostatic properties by CoMFA contours can be related to the PfDHFR inhibitory activit...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Anticonvulsant activity of novel 1-(morpholinomethyl)-3-substituted isatin derivatives
Publication date: June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 1 Author(s): Govindaraj Saravanan , Veerachamy Alagarsamy , Pandurangan Dineshkumar A variety of novel isatin derivatives 5a–5j and 6a–6j were synthesized and characterized by spectroscopic means and elemental analysis. The title compounds were investigated for antiepileptic activity using MES and scPTZ seizures tests. Neurotoxicity study was performed by the rotorod test. The relationship between the functional group variation and the biological activity of the evaluated compounds was discussed. Among the synt...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Spectrophotometric method for the determination of amlodipine besylate in pure and dosage forms using 7,7,8,8-tetracyanoquinodimethane and tetracyanoethylene
Publication date: June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 1 Author(s): Nina Alizadeh , Fatimeh Hemati Two simple, rapid and sensitive spectrophotometric methods for the determination of amlodipine besylate (ADB) in pure form and in pharmaceutical preparations have been developed. The methods are based on the charge transfer reactions between the drug as electron donor with 7,7,8,8-tetracyanoquinodimethane (TCNQ) and tetracyanoethylene (TCNE) as π-acceptors in order to the formation of charge transfer (CT) complexes. These reactions give colored products which have maximum...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research