Bulletin of Faculty of Pharmacy, Cairo University 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Formulation of risperidone loaded proniosomes for effective transdermal delivery: An in-vitro and in-vivo study
Publication date: December 2017Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 55, Issue 2Author(s): Sharda Sambhakar, Sarvesh Paliwal, Swapnil Sharma, Bishambar SinghAbstractIn the present investigation, proniosomes of risperidone were formulated, optimized and evaluated for effective transdermal delivery in order to overcome the bioavailability issues of orally administered risperidone. The proniosomes were prepared using various sorbitan esters with cholesterol and soya lecithin and were evaluated for in-vitro parameters, ex-vivo permeation and in-vivo performance. Results indicated that the vesicles w...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Formulation optimization and evaluation of fast dissolving film of aprepitant by using design of experiment
Publication date: Available online 7 May 2018Source: Bulletin of Faculty of Pharmacy, Cairo UniversityAuthor(s): Rajni Bala, Shailesh Sharma, IKGPTUAbstractThe concept of fast dissolving dosage form has become popular as new delivery system. This system will provide maximum therapeutic efficacy, increased bioavailability and maximum stability by reducing the frequency of dosage. It will also avoid first pass metabolism of the drugs. This system provides more rapid drug absorption from the pre gastric area which may provide quick onset of action. The present research aimed to prepare fast dissolving films (FDF) of aprepitan...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Evaluation of the physician’s acceptance to clinical pharmacy interventions after antibiotic stewardship implementation in the ICU in a general hospital in Egypt
ConclusionThe physicians in Al-Haram hospital appeared to accept the role of clinical pharmacist in correcting antibiotic-related DRPs as well as in implementing ASP. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Knowledge and practice of health care workers towards post exposure prophylaxis in the era of low and stable HIV prevalence in Southwestern Nigeria
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Wasiu Olalekan AdebimpeAbstractNigeria ranks top among the countries with the highest burden of Human Immune-deficiency Virus (HIV) infection. Despite ready-made access to HIV care, Post-Exposure Prophylaxis (PEP) practices have not increased commensurately due to several gaps within the health sector. This research was undertaken to assess knowledge and practice of health care workers towards PEP of HIV in Southwestern Nigeria. A descriptive cross sectional study was carried out among 300 health care workers ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Spectrophotometric analysis of two eye preparations, vial and drops, containing ketorolac tromethamine and phenylephrine hydrochloride binary mixture and their ternary mixture with chlorphenirmaine maleate
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Marwa A.A. Ragab, Fawzy A. El Yazbi, Ekram M. Hassan, Essam F. Khamis, Mohamed M.A. HamdyAbstractKetorolac tromethamine, KTC and phenylephrine hydrochloride, PHE binary mixture is co-formulated as eye vial, while their ternary mixture with chlorpheniramine maleate is co-formulated as eye drops. The existing work utilizes different spectrophotometric methods which are considered to be simple and rapid for the determination of both mixtures. These methods include: zero-order (D0), first derivative (D1), derivati...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Exploring community pharmacists’ knowledge, perception and experiences towards branded and generic medicines in Kuwait: Highlighting the role of pharmacist
ConclusionA national brand substitution policy should be formulated and implemented to assist pharmacists in the proper substitution practice and to help minimize the healthcare costs. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Notes on the genus Paramignya: Phytochemistry and biological activity
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Ninh The SonAbstractGenus Paramignya belongs to Rutaceae family, with interesting secondary metabolites, comprising main classes of compounds coumarin and coumarin glycosides, acridone alkaloids, tirucallane and tirucallane glycosides, phenols, and flavonoids, as well as several compounds limonoid, lignin glycoside and sterol. Paramignya species has been employing as folk medicines against hepatitis, diabetes, cancer, nose infections. Many bioactive reported such as cytotoxic assay, antioxidant, antiinflammato...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Chronomodulated drug delivery system of Irbesartan: Formulation and development using Desing of Experiment (DoE)
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Komal Parmar, Almas Shaikh, Hitesh DalvadiAbstractThe work is based on pulsatile principles to deliver a programmed dose of Irbesartan, an angiotensin-II receptor antagonist for chronotherapy of hypertension induced by excessive secretion of aldosterone, thereby lower the blood pressure at early morning. Solid dispersion of Irbesartan, a BCS class II drug, was prepared by using Poloxamer-188 by melt method in ratio of 1:1 to increase the dissolution properties of drug. Compressed coated pulsatile tablets inclu...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Quality risk management during pharmaceutical ‘good distribution practices’ – A plausible solution
This study addresses the gap in literature on quality risk management during supply chain operations. There are cases of unresolved customer complaints and batch failures originated due to inadequacies during distribution of pharmaceutical products. In absence of established quality risk management system during product shipment, there is no effective preventive plan related to risk factors. A corollary of manufacturing quality risk management has been drawn to the distribution of pharmaceutical products through this study. The quality risk management during pharmaceutical distribution may be useful to avoid market complai...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
In vitro permeation and stability studies on developed drug-in-adhesive transdermal patch of simvastatin
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Rabinarayan Parhi, Suresh PadilamAbstractThe transdermal drug-in-adhesive (DIA) patch of simvastatin (SM) was developed using acrylic adhesives such as DURO-TAK® 87-9301, DURO-TAK® 87-4287, DURO-TAK® 87-235A. The patches were evaluated for in vitro drug permeation across the pork ear skin using diffusion cell and stability studies. Among the three acrylic adhesives used, DURO-TAK® 87-9301 exhibited maximum flux (5.18 ± 0.23 µg/cm2/h). To further enhance the drug permeation, isopropyl myristate (IPM...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
A comparative study of in vitro antimicrobial, antioxidant and cytotoxic activity of Albizia lebbeck and Acacia nilotica stem bark
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Mohammad Tuhin Ali, Sheikh Tanzina Haque, Md. Lutful Kabir, Sohel Rana, Md. Enamul HaqueAbstractPetroleum ether, ethyl acetate and methanol extracts of the stem bark of Albizia lebbeck and Acacia nilotica was investigated for antimicrobial, antioxidant and cytotoxicity assay. The powdered stem bark was extracted successively with petroleum ether, ethyl acetate and methanol solution. The crude extracts were subjected to antimicrobial, antioxidant and cytotoxicity assay by using disc diffusion method, DPPH and h...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
The high lymphadenopathy and subcutaneous edema are associated with development of foot ulcer in type 2 diabetes: A collagen implanted antibiotic therapy
In this study, the possible efforts were made to prevent the diabetic foot ulcer of a patient. The diabetic foot ulcer, with tissue exposure and microbial infection on the surface of the foot, was treated with several antibiotics and dressings. The revascularization treatment procedure was started. The infection was reduced when compared with the beginning of this treatment. The collagen implant along with Gentamicin sulphate found that collagen was penetrated into the wound and helped the granulation of the tissue formation. The topical gentamicin reduced the bacterial contamination and cicatrization. The infective diabet...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Botanical and genetic characterization of Hydrocotyle umbellata L. cultivated in Egypt
This study targets the botanical features of the leaf, rhizome and roots, in addition to DNA fingerprinting using rapid amplified (RAPD) and inter simple sequence repeat (ISSR) based polymerase chain reaction (PCR) techniques. Microscopically, leaves and rhizomes are characterized by numerous brown schizogenous ducts containing volatile oils. On the other hand, a total of 34 random amplified polymorphic DNA (RAPD) markers were identified using seven random decamer primers and a total of 15 inter simple sequence repeat (ISSR) markers were identified using five decamer random primers. Both the botanical study and DNA fingerp...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Sapium ellipticum (Hochst) Pax leaf extract: Antioxidant potential in CCl4-induced oxidative stress model
ConclusionSE extract appears to have the phyto-proficiency to protect against membrane peroxidation and improve the activities of some first line antioxidant enzymes such a SOD and CAT in vivo. This is probably due to its array of bioactive compounds (α-tocopherol, amentoflavone and lupeol) which we have previously identified and reported. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Anti-hyperglycaemic activity of tuber extract of Chlorophytum alismifolium Baker in streptozotocin-induced hyperglycaemic rats
In conclusion, the results obtained suggest the tuber extract of Chlorophytum alismifolium possesses antihyperglycaemic activity.Graphical abstract (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
