Bulletin of Faculty of Pharmacy, Cairo University This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Spectrophotometric analysis of two eye preparations, vial and drops, containing ketorolac tromethamine and phenylephrine hydrochloride binary mixture and their ternary mixture with chlorphenirmaine maleate
Publication date: June 2018Source: Bulletin of Faculty of Pharmacy, Cairo University, Volume 56, Issue 1Author(s): Marwa A.A. Ragab, Fawzy A. El Yazbi, Ekram M. Hassan, Essam F. Khamis, Mohamed M.A. HamdyAbstractKetorolac tromethamine, KTC and phenylephrine hydrochloride, PHE binary mixture is co-formulated as eye vial, while their ternary mixture with chlorpheniramine maleate is co-formulated as eye drops. The existing work utilizes different spectrophotometric methods which are considered to be simple and rapid for the determination of both mixtures. These methods include: zero-order (D0), first derivative (D1), derivati...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Botanical and genetic characterization of Hydrocotyle umbellata L. cultivated in Egypt
This study targets the botanical features of the leaf, rhizome and roots, in addition to DNA fingerprinting using rapid amplified (RAPD) and inter simple sequence repeat (ISSR) based polymerase chain reaction (PCR) techniques. Microscopically, leaves and rhizomes are characterized by numerous brown schizogenous ducts containing volatile oils. On the other hand, a total of 34 random amplified polymorphic DNA (RAPD) markers were identified using seven random decamer primers and a total of 15 inter simple sequence repeat (ISSR) markers were identified using five decamer random primers. Both the botanical study and DNA fingerp...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

POM analyses, immunomodulatory, cytotoxic activities and polyphenolic constituents of Callistemon viridiflorus fruits
Publication date: Available online 28 June 2018Source: Bulletin of Faculty of Pharmacy, Cairo UniversityAuthor(s): Mohamed I.S. Abdelhady, Amel M. Kamal, Mohamed F. BarghashAbstractPhytochemical study on 80% ethanolic extract of Callistemon viridiflorus Sims fruits (CVF) resulted in isolation of five phenolic compounds 1; Gallic acid, 2; Ellagic acid, 3; Reynoutrin, 4; Methoxy ellagic acid, 5; Quercetin. Petra/Osiris/Molinspiration (POM) analyses predicted that Reynoutrin and Quercetin have interesting potential activities, also Reynoutrin is found to be safer in relation to Quercetin. 80% ethanolic extract of CVF, Reynout...
Source: Bulletin of Faculty of Pharmacy, Cairo University - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

POM analyses, immunomodulatory, cytotoxic activities and polyphenolic constituents of Callistemon viridiflorus fruits
Publication date: Available online 28 June 2018 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Mohamed I.S. Abdelhady, Amel M. Kamal, Mohamed F. Barghash Phytochemical study on 80% ethanolic extract of Callistemon viridiflorus Sims fruits (CVF) resulted in isolation of five phenolic compounds 1; Gallic acid, 2; Ellagic acid, 3; Reynoutrin, 4; Methoxy ellagic acid, 5; Quercetin. Petra/Osiris/Molinspiration (POM) analyses predicted that Reynoutrin and Quercetin have interesting potential activities, also Reynoutrin is found to be safer in relation to Quercetin. 80% ethanolic extract of CVF, Reynoutr...
Source: Bulletin of Faculty of Pharmacy, Cairo University - June 29, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluation of the physician ’s acceptance to clinical pharmacy interventions after antibiotic stewardship implementation in the ICU in a general hospital in Egypt
Conclusion The physicians in Al-Haram hospital appeared to accept the role of clinical pharmacist in correcting antibiotic-related DRPs as well as in implementing ASP. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - May 22, 2018 Category: Drugs & Pharmacology Source Type: research

Formulation optimization and evaluation of fast dissolving film of aprepitant by using design of experiment
Publication date: Available online 7 May 2018 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Rajni Bala, Shailesh Sharma The concept of fast dissolving dosage form has become popular as new delivery system. This system will provide maximum therapeutic efficacy, increased bioavailability and maximum stability by reducing the frequency of dosage. It will also avoid first pass metabolism of the drugs. This system provides more rapid drug absorption from the pre gastric area which may provide quick onset of action. The present research aimed to prepare fast dissolving films (FDF) of aprepitant used in ...
Source: Bulletin of Faculty of Pharmacy, Cairo University - May 8, 2018 Category: Drugs & Pharmacology Source Type: research

Identification of possible Ser/Thr/Tyr phosphorylation sites in the fungal histidine kinase CaNik1p by peptide array technique
In this study, we aimed to identify additional possible P-sites in this HK. Therefore, we constructed a peptide array that covers the full length protein. Incubation of the purified His-tagged CaNik1p with the peptide array in the presence of radioactive ATP [γ-32P] revealed the possible P-sites in each peptide. We classified the peptides according to their intensities. Peptides bearing His510 and D924 showed either null or very weak intensities. The highest intensity was corresponding to the peptide containing the amino acid T994, while lower intensities were related mainly to serine and threonine residues and to lower e...
Source: Bulletin of Faculty of Pharmacy, Cairo University - April 8, 2018 Category: Drugs & Pharmacology Source Type: research

In vitro permeation and stability studies on developed drug-in-adhesive transdermal patch of simvastatin
Publication date: Available online 7 April 2018 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Rabinarayan Parhi, Suresh Padilam The transdermal drug-in-adhesive (DIA) patch of simvastatin (SM) was developed using acrylic adhesives such as DURO-TAK® 87-9301, DURO-TAK® 87-4287, DURO-TAK® 87-235A. The patches were evaluated for in vitro drug permeation across the pork ear skin using diffusion cell and stability studies. Among the three acrylic adhesives used, DURO-TAK® 87-9301 exhibited maximum flux (5.18 ± 0.23 µg/cm2/h). To further enhance the drug permeation, isopropyl myristate (IPM),...
Source: Bulletin of Faculty of Pharmacy, Cairo University - April 7, 2018 Category: Drugs & Pharmacology Source Type: research

Botanical and genetic characterization of Hydrocotyle umbellata L. cultivated in Egypt
This study targets the botanical features of the leaf, rhizome and roots, in addition to DNA fingerprinting using rapid amplified (RAPD) and inter simple sequence repeat (ISSR) based polymerase chain reaction (PCR) techniques. Microscopically, leaves and rhizomes are characterized by numerous brown schizogenous ducts containing volatile oils. On the other hand, a total of 34 random amplified polymorphic DNA (RAPD) markers were identified using seven random decamer primers and a total of 15 inter simple sequence repeat (ISSR) markers were identified using five decamer random primers. Both the botanical study and DNA fingerp...
Source: Bulletin of Faculty of Pharmacy, Cairo University - April 6, 2018 Category: Drugs & Pharmacology Source Type: research

Exploring community pharmacists ’ knowledge, perception and experiences towards branded and generic medicines in Kuwait: Highlighting the role of pharmacist
Conclusion A national brand substitution policy should be formulated and implemented to assist pharmacists in the proper substitution practice and to help minimize the healthcare costs. (Source: Bulletin of Faculty of Pharmacy, Cairo University)
Source: Bulletin of Faculty of Pharmacy, Cairo University - April 3, 2018 Category: Drugs & Pharmacology Source Type: research

Quinazolino-thiadiazoles as antimicrobial agents
Publication date: Available online 24 March 2018 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Harun Patel, Atul Shirkhedkar, Sanjay Bari, Kamalkishor Patil, Amit Arambhi, Chandrakantsing Pardeshi, Abhijeet Kulkarni, Sanjay Surana In the present research, we report the synthesis and in vitro antimicrobial activity of a new series of novel quinazolino-thiadiazoles as fused pharmacophore (3–20). In general, the results of the in vitro antibacterial activity are encouraging, as out of 18 compounds tested, Compounds 3 and 8 with a 4-chlorophenyl and 4-nitro phenyl at C-2 of thiadiazole and chl...
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 24, 2018 Category: Drugs & Pharmacology Source Type: research

Spectrophotometric analysis of two eye preparations, vial and drops, containing ketorolac tromethamine and phenylephrine hydrochloride binary mixture and their ternary mixture with chlorphenirmaine maleate
Publication date: Available online 21 March 2018 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Marwa A.A. Ragab, Fawzy A. El Yazbi, Ekram M. Hassan, Essam F. Khamis, Mohamed M.A. Hamdy Ketorolac tromethamine, KTC and phenylephrine hydrochloride, PHE binary mixture is co-formulated as eye vial, while their ternary mixture with chlorpheniramine maleate is co-formulated as eye drops. The existing work utilizes different spectrophotometric methods which are considered to be simple and rapid for the determination of both mixtures. These methods include: zero-order (D0), first derivative (D1), deriva...
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 21, 2018 Category: Drugs & Pharmacology Source Type: research

The high lymphadenopathy and subcutaneous edema are associated with development of foot ulcer in type 2 diabetes: A collagen implanted antibiotic therapy
In this study, the possible efforts were made to prevent the diabetic foot ulcer of a patient. The diabetic foot ulcer, with tissue exposure and microbial infection on the surface of the foot, was treated with several antibiotics and dressings. The revascularization treatment procedure was started. The infection was reduced when compared with the beginning of this treatment. The collagen implant along with Gentamicin sulphate found that collagen was penetrated into the wound and helped the granulation of the tissue formation. The topical gentamicin reduced the bacterial contamination and cicatrization. The infective diabet...
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 21, 2018 Category: Drugs & Pharmacology Source Type: research

Knowledge and practice of health care workers towards post exposure prophylaxis in the era of low and stable HIV prevalence in Southwestern Nigeria
Publication date: Available online 13 March 2018 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Wasiu Olalekan Adebimpe Nigeria ranks top among the countries with the highest burden of Human Immune-deficiency Virus (HIV) infection. Despite ready-made access to HIV care, Post-Exposure Prophylaxis (PEP) practices have not increased commensurately due to several gaps within the health sector. This research was undertaken to assess knowledge and practice of health care workers towards PEP of HIV in Southwestern Nigeria. A descriptive cross sectional study was carried out among 300 health care workers se...
Source: Bulletin of Faculty of Pharmacy, Cairo University - March 14, 2018 Category: Drugs & Pharmacology Source Type: research

Radical scavenging potential, antiinflammatory and antiarthritic activity of isolated isomer Methyl- γ-Orsellinate and roccellatol from Roccella montagnei Bel
Publication date: Available online 13 February 2018 Source:Bulletin of Faculty of Pharmacy, Cairo University Author(s): Syed Zameer Ahmed Khader, Sidhra Syed Zameer Ahmed, Thangakumar Arunachalam, Sanjeeva Nayaka, Senthil Kumar Balasubramanian, Syed Tajudeen SyedAmeen, Ponmurugan Ponnusamy The burden of multiple drug resistance towards chronic diseases is rapidly increasing globally at an alarm rate. The present study aims to isolate active principles via bioassay guided fractionation of traditionally used lichen Roccella montagnei for in vitro radical scavenging activity with potential to combat arthritis and inf...
Source: Bulletin of Faculty of Pharmacy, Cairo University - February 14, 2018 Category: Drugs & Pharmacology Source Type: research